Endothelial progenitor cells and peripheral neuropathy in subjects with type 2 diabetes mellitus

Eleftheriadou, Ioanna; Dimitrakopoulou, Natalia; Kafasi, Nikolitsa; Tentolouris, Anastasios; Dimitrakopoulou, Aglaia; Anastasiou, Ioanna A.; Mourouzis, Iordanis; Jude, Edward B.; Tentolouris, Nikolaοs

doi:10.1016/j.jdiacomp.2019.107517

Cited by 10 publications

(7 citation statements)

References 40 publications

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“…El Sheikh et al (2019) [ 9 ] found increased TNF-α in mild and moderate-severe DPN compared to no DPN. Conversely, Eleftheriadou et al (2020) [ 14 ] observed no significant TNF-α difference between diabetics with and without DPN. Ge et al (2016) [ 15 ] related TNF-α with DPN development.…”

Section: Reviewmentioning

confidence: 98%

Unraveling the Role of Tumor Necrosis Factor-Alpha in Diabetic Peripheral Neuropathy: A Systematic Review and Meta-Analysis

Sen,

Mohanraj,

Ranjan

et al. 2023

Cureus

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Diabetic peripheral neuropathy (DPN) is a prevalent and debilitating complication of diabetes mellitus, leading to sensory abnormalities, decreased balance, and increased risk of foot problems. Although tumor necrosis factor-alpha (TNF-α) has emerged as a potential factor in the pathogenesis of DPN, its role remains contested. This study intends to thoroughly analyze the association between TNF-α and DPN by combining data from various global studies. This systematic review and meta-analysis adhered to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines and included 23 articles investigating TNF-α levels in DPN patients for systematic review and 11 articles for meta-analysis. Data were extracted, and heterogeneity was examined. A random-effect model was chosen due to high heterogeneity. The major outcome measure across studies was serum TNF-α levels. The meta-analysis found a significant mean difference of 15.2464 (95% confidence interval = 4.4963; 25.9965) under the random-effect model due to the substantial heterogeneity (I 2 = 98.1%) among included studies. The meta-analysis indicates a consistent elevation in TNF-α levels in individuals with DPN compared to those without neuropathy. This underlines the potential of TNF-α as a biomarker and contributor to diabetic neuropathy. Despite heterogeneity, the study’s extensive scope and systematic approach enhance the trustworthiness and generalizability of the findings.

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Section: Reviewmentioning

confidence: 98%

Unraveling the Role of Tumor Necrosis Factor-Alpha in Diabetic Peripheral Neuropathy: A Systematic Review and Meta-Analysis

Sen,

Mohanraj,

Ranjan

et al. 2023

Cureus

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“…Apart from solid tissue cancer, circulating EnC and EPC have been associated with many other pathologies and this constitutes a serious pitfall when used as independent markers in cancer diagnosis. In the know of an incomplete list, endothelial elevation may occur upon ischemia, congestive heart failure, myocardial infarction (MI), sepsis, vascular trauma, hypertension, hyperlipidaemia, and hyperglycaemia, acute and chronic infection [94,95], sickle cell anemia, vasculitis, diabetes type II [96] deep vein thrombosis) [75,76], granulomatosis [5], pulmonary hypertension [74] or cirrhosis [97]. In inflammation, circulating EnC and EPC may interact with each other where inflammation activated circulating EnC induce EPC dysfuntion [5].…”

Section: Endothelial Cell Clinical Usementioning

confidence: 99%

“…In inflammation, circulating EnC and EPC may interact with each other where inflammation activated circulating EnC induce EPC dysfuntion [5]. Consequently, it is worthwhile to investigate several phenotypes at the same time to obtain greater picture of the disorder [96]. In contrast to mature EnC, EPC numbers were often reported to be inversely correlated with disease [98].…”

Section: Endothelial Cell Clinical Usementioning

confidence: 99%

“…EPC deprivation in numbers could mean a reduction by half which was found when comparing pulmonary arterial hypertension patients with healthy controls [74]. In diabetes, circulating EPC were reported to be decreased [59], but also increased [96] therefore requiring a closer look into the patient status. Circulating EPC elevation may indicate diabetes type 2 related peripheral neuropathy [96].…”

Section: Endothelial Cell Clinical Usementioning

confidence: 99%

“…In diabetes, circulating EPC were reported to be decreased [59], but also increased [96] therefore requiring a closer look into the patient status. Circulating EPC elevation may indicate diabetes type 2 related peripheral neuropathy [96]. A similar controversy seems to persist about liver cirrhosis that was reported to elicit EPC deprivation by Chen et al [102], yet more recently, was associated with EPC elevation [97].…”

Section: Endothelial Cell Clinical Usementioning

confidence: 99%

See 2 more Smart Citations

The Blood Circulating Rare Cell Population. What Is It and What Is It Good for?

Schreier

Triampo

2020

Cells

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Blood contains a diverse cell population of low concentration hematopoietic as well as non-hematopoietic cells. The majority of such rare cells may be bone marrow-derived progenitor and stem cells. This paucity of circulating rare cells, in particular in the peripheral circulation, has led many to believe that bone marrow as well as other organ-related cell egress into the circulation is a response to pathological conditions. Little is known about this, though an increasing body of literature can be found suggesting commonness of certain rare cell types in the peripheral blood under physiological conditions. Thus, the isolation and detection of circulating rare cells appears to be merely a technological problem. Knowledge about rare cell types that may circulate the blood stream will help to advance the field of cell-based liquid biopsy by supporting inter-platform comparability, making use of biological correct cutoffs and “mining” new biomarkers and combinations thereof in clinical diagnosis and therapy. Therefore, this review intends to lay ground for a comprehensive analysis of the peripheral blood rare cell population given the necessity to target a broader range of cell types for improved biomarker performance in cell-based liquid biopsy.

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Neuropathic complications: Type II diabetes mellitus and other risky parameters using machine learning algorithms

Usharani

Shanthini

2021

J Ambient Intell Human Comput

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Endothelial progenitor cells and peripheral neuropathy in subjects with type 2 diabetes mellitus

Cited by 10 publications

References 40 publications

Unraveling the Role of Tumor Necrosis Factor-Alpha in Diabetic Peripheral Neuropathy: A Systematic Review and Meta-Analysis

Unraveling the Role of Tumor Necrosis Factor-Alpha in Diabetic Peripheral Neuropathy: A Systematic Review and Meta-Analysis

The Blood Circulating Rare Cell Population. What Is It and What Is It Good for?

Neuropathic complications: Type II diabetes mellitus and other risky parameters using machine learning algorithms

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