Endothelial progenitor cells &amp; translational research

Ritter, JM

doi:10.1111/j.1365-2125.2009.03538.x

Cited by 2 publications

(1 citation statement)

References 18 publications

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“…Therapeutic options with endothelial progenitor cells are still in their infancy and its success will strongly depend on whether translational medicine delivers an understanding of the function of these cells, in relation to underlying microvascular dysfunction, surgical stress, and critical illness. 11 It is anticipated that endothelial progenitor cells will provide innovative diagnostic and therapeutic approaches in the perioperative period.…”

Section: Modulation Of Endothelial Functionmentioning

confidence: 99%

Endothelial Dysfunction in the Perioperative Setting

Riedel

Schier

2010

Semin Cardiothorac Vasc Anesth

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Although perioperative macrovascular events (eg, myocardial infarction, stroke) are readily evident, their absolute incidence remains relatively low. In contrast, microvascular dysfunction and its role in perioperative morbidity is not easily measured. Microvascular dysfunction is likely to have a greater impact on noncardiovascular complications (eg, wound healing and end-organ failure), through impaired perfusion, than that which is readily appreciated. Inflammation and oxidative stress, such as that induced by surgical trauma, disrupts endothelial homeostasis thereby decreasing the bioavailability of nitric oxide. This predisposes blood vessels to vasoconstriction, inflammation, leukocyte adhesion, thrombosis-factors that contribute to perioperative cardiovascular events at both macrovascular and microvascular level. Current clinical strategies applicable to the perioperative setting that improve microvascular health include preoperative exercise therapy, pharmacologic interventions (eg, statins, newer beta-blockers) and attempts to stimulate mobilization and homing of bone marrow-derived endothelial progenitor cells. Many of these strategies are still in their infancy and large prospective trials that investigate the impact of these therapeutic options on postoperative outcome are eagerly awaited.

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Section: Modulation Of Endothelial Functionmentioning

confidence: 99%