Endothelial microparticle-associated protein disulfide isomerase increases platelet activation in diabetic coronary heart disease

Sun, Xiaodi; Han, Lu; Lan, Hong-tao; Qin, Ran-ran; Song, Ming; Zhang, Wei; Zhong, Ming; Wang, Zhi-Hao

doi:10.18632/aging.203316

Cited by 7 publications

(2 citation statements)

References 63 publications

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“…As promising vesicular markers associated with endothelial dysfunction in Type 2 diabetes mellitus (DM2) are the level of CD31+CD144+ EVs, the level of miR-126 in circulating EVs, and an increased ratio of CD31+Annexin V+ EVs to CD31+CD62+ EVs, reflecting the altered immune phenotype of endothelial cell-derived EVs [ 3 , 4 ]. Vesicular markers are successfully used as markers of an increased risk of cardiovascular disease complications in obesity, DM2, and metabolic syndrome (perilipin A, cystatin C, CD14, miR21, disulfide isomerase levels on CD31-positive BBs) [ 3 , 5 , 6 , 7 ]. Several miRNAs have been identified in urinary EVs associated with diabetic nephropathy and renal fibrosis.…”

Section: Proteins and Mirnas Of Extracellular Vesicles (Evs) As Bioma...mentioning

confidence: 99%

The Role of Intravesicular Proteins and the Protein Corona of Extracellular Vesicles in the Development of Drug-Induced Polyneuropathy

Yunusova

Popova

Udintseva

et al. 2023

CIMB

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Extracellular vesicles (EVs) as membrane structures of cellular origin participating in intercellular communication are involved in the molecular mechanisms of the development of various variants of polyneuropathy. Taking into account the increasing role of the protein corona of EVs and protein-protein interactions on the surface of EVs in the pathogenesis of various diseases, we focused our attention in this review on the role of intravesicular proteins and the protein corona of EVs in the development of chemotherapy-induced polyneuropathy (CIPN). It has been shown that EVs are effectively internalized by the mechanisms of endocytosis and macropinocytosis by neurocytes and glial cells, carry markers of insulin resistance, functionally active proteins (receptors, cytokines, enzymes), and may be involved in the pathogenesis of CIPN. The mechanisms of CIPN associated with the EVs protein corona can be related with the accumulation of heavy chains of circulating IgG in it. G-class immunoglobulins in EVs are likely to have myelin hydrolyzing, superoxide dismutase, and oxidoreductase enzymatic activities. Moreover, circulating IgG-loaded EVs are a place for complement activation that can lead to membrane attack complex deposition in neuroglia and neurons. The mechanisms of CIPN development that are not associated with IgG in the EVs protein corona are somehow related to the fact that many anticancer drugs induce apoptosis of tumor cells, neurons, and neuroglial cells by various mechanisms. This process may be accompanied by the secretion of EVs with modified cargo (HSPs, 20S proteasomes, miRNAs).

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Section: Proteins and Mirnas Of Extracellular Vesicles (Evs) As Bioma...mentioning

confidence: 99%

The Role of Intravesicular Proteins and the Protein Corona of Extracellular Vesicles in the Development of Drug-Induced Polyneuropathy

Yunusova

Popova

Udintseva

et al. 2023

CIMB

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“… 10 Furthermore, in patients with diabetes with CVD, the PDMPs were multiplied, indicating platelet activation in this population. 11 During an AMI episode, more enhanced platelet activation and subsequent platelet-enriched thrombus formation among patients with diabetes mellitus may amplify the production of PDMPs. However, despite the abundant data on increased circulating PDMPs among diabetes mellitus and stable CVD, the impact of acute hyperglycemia and diabetes mellitus during AMI on circulating PDMPs release has not yet been investigated.…”

Section: Introductionmentioning

confidence: 99%

Association of Acute Hyperglycemia and Diabetes Mellitus with Amount of Platelets Derived Microparticles During Acute Myocardial Infarction

Indana,

Puspitawati,

Mayasari

et al. 2023

JAFES

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Objectives This research investigates whether there is an association between acute hyperglycemia and diabetes mellitus and the level of circulating platelet-derived microparticles (PDMPs) during an initial episode of acute myocardial infarction (AMI). Methodology This was a cross-sectional study involving hospitalized AMI patients. Demographic and clinical data were obtained from hospital records. Diabetes mellitus was defined by the history of the disease, anti-diabetes medication use and/ or level of HbA1C ≥6.5%. Levels of HbA1c, admission random and fasting blood glucose levels were measured. Flow-cytometry method was used to determine the levels of PDMPs from collected venous blood through tagging with CD-41 FITC and CD-62 PE markers and a threshold size of <1 μm. The number of circulating PDMPs was compared according to glucometabolic state, namely acute hyperglycemia (admission random glucose ≥200 mg/dL and fasting glucose ≥140 mg/dL) and diabetes mellitus. The comparative analysis between groups was conducted with Student T-test or Mann-Whitney test, where applicable. Results A total of 108 subjects were included and their data analyzed. The level of circulating PDMPs was significantly lower in subjects with admission random glucose ≥200 mg/dL as compared to those with below level [median (interquartile range (IQR)]: 2,710.0 (718.0-8,167.0) count/mL vs. 4,452.0 (2,128.5-14,499.8) count/mL, p = 0.05) and in subjects with fasting glucose ≥140 mg/dL as compared to those with below level (median (IQR): 2,382.0 (779.0-6,619.0) count/mL vs. 5,972.0 (2,345.7-14,781.3) count/mL, p = 0.006). The level of circulating PDMPs was also significantly lower in patients with diabetes mellitus as compared to those without (median (IQR): 2,655.0 (840.0-5,821.0) count/mL vs. 4,562.0 (2,128.5-15,055.8) count/mL; p = 0.007). Conclusion Acute hyperglycemia and diabetes mellitus are significantly associated with a lower circulating PDMP level during an initial AMI episode.

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Naringin binds to protein disulfide isomerase to inhibit its activity and modulate the blood coagulation rates: Implications in controlling thrombosis

Khan,

Siddiqui,

Fatima

et al. 2023

International Journal of Biological Macromolecules

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Endothelial microparticle-associated protein disulfide isomerase increases platelet activation in diabetic coronary heart disease

Cited by 7 publications

References 63 publications

The Role of Intravesicular Proteins and the Protein Corona of Extracellular Vesicles in the Development of Drug-Induced Polyneuropathy

The Role of Intravesicular Proteins and the Protein Corona of Extracellular Vesicles in the Development of Drug-Induced Polyneuropathy

Association of Acute Hyperglycemia and Diabetes Mellitus with Amount of Platelets Derived Microparticles During Acute Myocardial Infarction

Naringin binds to protein disulfide isomerase to inhibit its activity and modulate the blood coagulation rates: Implications in controlling thrombosis

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