Endothelial interactions of neutrophils under flow in chronic obstructive pulmonary disease

Woolhouse, Ian

doi:10.1183/09031936.05.00086304

Cited by 37 publications

(24 citation statements)

References 17 publications

(22 reference statements)

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“…There is evidence of aberrant neutrophil migration in usual COPD [42], which is not present in A1ATD [43,44], and differences in the adherence and speed of migrating neutrophils in COPD could, theoretically, lead to an increased neutrophil presence and degranulation in the airways, despite lower concentrations of chemoattractants, potentially explaining the lower neutrophil numbers in A1ATD despite higher chemoattractant concentrations.…”

Section: Discussionmentioning

confidence: 99%

Variability of sputum inflammatory mediators in COPD and α₁-antitrypsin deficiency

et al. 2012

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There is inherent daily variability of sputum inflammatory mediators in stable-state patients with usual chronic obstructive pulmonary disease (COPD). The variability of pulmonary inflammation in patients with a 1 -antitrypsin deficiency (A1ATD) is unknown. Our study aimed to quantify this variability, in comparison to patients with usual COPD, in order to facilitate power calculations for proof of concept trials of putative specific anti-inflammatory agents in both groups.Sputum interleukin (IL)-8, myeloperoxidase (MPO), leukotriene B 4 (LTB 4 ) and differential cell counts were measured in 12 usual COPD patients and 12 A1ATD patients on nine occasions over a 1-month period. All samples were obtained in the stable clinical state.There was significant daily variability in all mediators in all patients. A1ATD patients had higher sputum concentrations of IL-8 and LTB 4 compared with usual COPD, but lower levels of MPO and absolute neutrophil counts. Patients with usual COPD had more intra-patient variability, A1ATD patients demonstrated greater inter-patient variability.There are increased concentrations of pulmonary inflammatory mediators but fewer sputum neutrophils in A1ATD compared with usual COPD. The daily variability of inflammatory mediators and cell counts was significantly reduced in both groups by averaging sequential samples. This can be utilised to perform power calculations for future proof of concept studies; averaging three sequential samples appears optimum.

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Section: Discussionmentioning

confidence: 99%

Variability of sputum inflammatory mediators in COPD and α₁-antitrypsin deficiency

et al. 2012

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“…A number of studies suggest that neutrophils from patients with COPD display increased adhesion and migration towards inflammatory stimuli [48][49][50], although this has not been universally replicated [51]. These studies provide information on bulk cell movement towards a chemo-attractant at the end of a given timeframe.…”

Section: Neutrophil Adhesion and Migration In Copdmentioning

confidence: 91%

Aberrant neutrophil functions in stable chronic obstructive pulmonary disease: The neutrophil as an immunotherapeutic target

Stockley

Walton

Lord

et al. 2013

International Immunopharmacology

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“…Upregulation of neutrophil adhesion molecules such as CD621 and macrophage antigen (MAC)-1 (CD11b/CD18) increases neutrophil-endothelial cell interaction. 7 In patients with COPD, neutrophils have been shown to have increased surface expression of MAC-1. 8 This is important, because it is thought MAC-1 (CD11b/CD18) facilitates neutrophil adhesion via its endothelial counter receptor intercellular adhesion molecule 1 (ICAM-1).…”

Section: Transepithelial Neutrophil Migrationmentioning

confidence: 99%

The neutrophil in chronic obstructive pulmonary disease

Quint

Wedzicha

2007

Journal of Allergy and Clinical Immunology

140

103

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Endothelial interactions of neutrophils under flow in chronic obstructive pulmonary disease

Cited by 37 publications

References 17 publications

Variability of sputum inflammatory mediators in COPD and α₁-antitrypsin deficiency

Variability of sputum inflammatory mediators in COPD and α₁-antitrypsin deficiency

Aberrant neutrophil functions in stable chronic obstructive pulmonary disease: The neutrophil as an immunotherapeutic target

The neutrophil in chronic obstructive pulmonary disease

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Endothelial interactions of neutrophils under flow in chronic obstructive pulmonary disease

Cited by 37 publications

References 17 publications

Variability of sputum inflammatory mediators in COPD and α1-antitrypsin deficiency

Variability of sputum inflammatory mediators in COPD and α1-antitrypsin deficiency

Aberrant neutrophil functions in stable chronic obstructive pulmonary disease: The neutrophil as an immunotherapeutic target

The neutrophil in chronic obstructive pulmonary disease

Contact Info

Product

Resources

About

Variability of sputum inflammatory mediators in COPD and α₁-antitrypsin deficiency

Variability of sputum inflammatory mediators in COPD and α₁-antitrypsin deficiency