Endothelial Glycocalyx Layer Shedding Following Lung Resection

Arthur, A.S.; McCall, Pamela; Jolly, Lisa; Kinsella, John P.; Kirk, Alan; Shelley, Ben

doi:10.2217/bmm-2016-0163

Cited by 17 publications

(20 citation statements)

References 15 publications

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“… 41 – 43 Disruption of the endothelial glycocalyx has been demonstrated following surgical trauma or severe injury. 44 – 46 Consequently, a vicious cycle of postoperative damage to the endothelial glycocalyx and hypoalbuminaemia may contribute to transcapillary albumin leakage and interstitial oedema in patients undergoing hip fracture surgery.…”

Section: Discussionmentioning

confidence: 99%

<p>Early Postoperative Hypoalbuminaemia as a Risk Factor for Postoperative Pneumonia Following Hip Fracture Surgery</p>

Shin

Kim

Son

et al. 2020

CIA

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Purpose: Postoperative pneumonia is a common and devastating complication of hip fracture surgery in older individuals. This study aimed to determine the relationship between early postoperative hypoalbuminaemia and pneumonia after hip fracture surgery. Patients and Methods: In this retrospective cohort study conducted at one centre, we reviewed the medical records of 1155 consecutive patients (>60 years) who underwent hip fracture surgery. Multivariate logistic regression analysis was performed to identify the independent risk factors for postoperative pneumonia. After determining the cutoff value for postoperative serum albumin, the patients were divided into two groups according to the minimum serum albumin level recorded during the first two postoperative days: group A included patients with a minimum serum album level less than 3.0 g/dL and group B included patients with a minimum serum album level of at least 3.0 g/dL. The prevalence of postoperative pneumonia was analysed using inverse probability of treatment weighting (IPTW) and propensity score matching (PSM) analyses. Results: The incidence of postoperative pneumonia following hip fracture surgery was 5.1% (n=59). Age, cardiovascular disease, and early postoperative hypoalbuminaemia during the first two postoperative days were independent risk factors for postoperative pneumonia. Early postoperative hypoalbuminaemia was associated with postoperative pneumonia development in the PSM and IPTW analyses (P = 0.016 and <0.001, respectively). Conclusion: This study demonstrated that early postoperative hypoalbuminaemia is an independent risk factor for the development of postoperative pneumonia in patients undergoing hip fracture surgery.

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Section: Discussionmentioning

confidence: 99%

<p>Early Postoperative Hypoalbuminaemia as a Risk Factor for Postoperative Pneumonia Following Hip Fracture Surgery</p>

Shin

Kim

Son

et al. 2020

CIA

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“…Syndecan-1 has been used as a marker for glycocalyx injury in several clinical reports. 25,27,28 It was recently reported that measurement of syndecan-1 levels in patients with sepsis might be useful for identifying those at high risk of organ dysfunction and mortality as well as those who could benefit from therapies targeted at protecting or restoring the glycocalyx. 27 Therefore, it is surmised that glycocalyx injuries have a relation with human disease.…”

Section: Discussionmentioning

confidence: 99%

Ultrastructural Alteration of Pulmonary Capillary Endothelial Glycocalyx During Endotoxemia

Inagawa

Okada

Takemura

et al. 2018

Chest

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“…The endothelial glycocalyx covers the inner surface of the vascular endothelium and regulates leukocyte adhesion [20], thus, leukocytes cannot adhere to endothelial cells covered with glycocalyx, and endothelial glycocalyx injury may occur prior to atherosclerotic changes. Syndecan-1 is a component of the glycocalyx, and its degradation indicates endothelial injury [24,27,28]. In this study, to detect initial endothelial cell injury, we investigated syndecan-1 concentrations in patients who underwent comprehensive medical examinations.…”

Section: Discussionmentioning

confidence: 99%

Factors Enhancing Serum Syndecan-1 Concentrations: A Large-Scale Comprehensive Medical Examination

Oda

Okada

Suzuki

et al. 2019

JCM

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Endothelial disorders are related to various diseases. An initial endothelial injury is characterized by endothelial glycocalyx injury. We aimed to evaluate endothelial glycocalyx injury by measuring serum syndecan-1 concentrations in patients during comprehensive medical examinations. A single-center, prospective, observational study was conducted at Asahi University Hospital. The participants enrolled in this study were 1313 patients who underwent comprehensive medical examinations at Asahi University Hospital from January 2018 to June 2018. One patient undergoing hemodialysis was excluded from the study. At enrollment, blood samples were obtained, and study personnel collected demographic and clinical data. No treatments or exposures were conducted except for standard medical examinations and blood sample collection. Laboratory data were obtained by the collection of blood samples at the time of study enrolment. According to nonlinear regression, the concentrations of serum syndecan-1 were significantly related to age (p = 0.016), aspartic aminotransferase concentration (AST, p = 0.020), blood urea nitrogen concentration (BUN, p = 0.013), triglyceride concentration (p < 0.001), and hematocrit (p = 0.006). These relationships were independent associations. Endothelial glycocalyx injury, which is reflected by serum syndecan-1 concentrations, is related to age, hematocrit, AST concentration, BUN concentration, and triglyceride concentration.

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Endothelial Glycocalyx Layer Shedding Following Lung Resection

Cited by 17 publications

References 15 publications

<p>Early Postoperative Hypoalbuminaemia as a Risk Factor for Postoperative Pneumonia Following Hip Fracture Surgery</p>

<p>Early Postoperative Hypoalbuminaemia as a Risk Factor for Postoperative Pneumonia Following Hip Fracture Surgery</p>

Ultrastructural Alteration of Pulmonary Capillary Endothelial Glycocalyx During Endotoxemia

Factors Enhancing Serum Syndecan-1 Concentrations: A Large-Scale Comprehensive Medical Examination

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