Endothelial function in patients with chronic myeloid leukemia treated with tyrosine kinase inhibitors is not related to cardiovascular risk assessed by SCORE2 algorithm

Abstract

What's newEndothelial function in chronic myeloid leukemia (CML) patients treated with various tyrosine kinase inhibitors (TKIs) was comprehensively analyzed in conduit arteries and microcirculation using flow-mediated dilation (FMD), reactive hyperemia peripheral arterial tonometry (RH-PAT), and Flow Mediated Skin Fluorescence (FMSF). Based on this approach, we demonstrated that endothelial function was not related to cardiovascular risk evaluated based on SCORE2 / SCORE2-OP algorithms but was dependent on CML-specific factors, including the total duration of TKI treatment. In particular, our results suggest that CML may have an impact on the microcirculation of the skin, reflecting a systemic nature of the microvascular dysfunctional state in CML patients, which seemed to be further modulated by the TKI treatment. On the practical side, our results suggest that FMSF-based assessment of skin microcirculation may prove useful to detect vascular effects of TKIs and to guide the vascular safety of TKI therapy.