Endothelial function, arterial stiffness and heart rate variability of patients with cardiovascular diseases hospitalized due to COVID-19

Araújo, Claudia Regina da Silva; Fernandes, Juliana; Caetano, Débora Sidrônio; Barros, Ana Eugênia Vasconcelos do Rêgo; Souza, Juliana Andrade Ferreira de; Machado, Marina Amaral de Ávila; Aguiar, Maria Inês Remígio de; Brandão, Simone Cristina Soares; Campos, Shirley Lima; Andrade, Armèle de Fátima Dornelas de; Brandão, Daniella Cunha

doi:10.1016/j.hrtlng.2022.12.016

Cited by 10 publications

(3 citation statements)

References 36 publications

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“…46,47 These factors contribute to arterial damage, accelerate atherosclerosis, and increase the risk of CVD. 48 Additionally, patients with obesity have elevated lipopolysaccharidebinding protein levels, potentially due to chronic inflammation altering intestinal flora and gut permeability to lipopolysaccharide, which can destroy endothelial cells. 49 Women with preeclampsia exhibit increases in arterial stiffness at 7 weeks postpartum, as shown by increases in augmentation index, carotid-femoral pulse wave analysis, and carotid-radial pulse wave velocity.…”

Section: Arterial Dysfunctionmentioning

confidence: 99%

Hypertension Related Co-Morbidities and Complications in Women of Sub-Saharan Africa: A Brief Review

Hahka,

Slotkowski,

Akbar

et al. 2024

Circulation Research

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Hypertension is the leading cause of cardiovascular disease in women, and sub-Saharan African (SSA) countries have some of the highest rates of hypertension in the world. Expanding knowledge of causes, management, and awareness of hypertension and its co-morbidities worldwide is an effective strategy to mitigate its harms, decrease morbidities and mortality, and improve individual quality of life. Hypertensive disorders of pregnancy (HDPs) are a particularly important subset of hypertension, as pregnancy is a major stress test of the cardiovascular system and can be the first instance in which cardiovascular disease is clinically apparent. In SSA, women experience a higher incidence of HDP compared with other African regions. However, the region has yet to adopt treatment and preventative strategies for HDP. This delay stems from insufficient awareness, lack of clinical screening for hypertension, and lack of prevention programs. In this brief literature review, we will address the long-term consequences of hypertension and HDP in women. We evaluate the effects of uncontrolled hypertension in SSA by including research on heart disease, stroke, kidney disease, peripheral arterial disease, and HDP. Limitations exist in the number of studies from SSA; therefore, we will use data from countries across the globe, comparing and contrasting approaches in similar and dissimilar populations. Our review highlights an urgent need to prioritize public health, clinical, and bench research to discover cost-effective preventative and treatment strategies that will improve the lives of women living with hypertension in SSA.

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Section: Arterial Dysfunctionmentioning

confidence: 99%

Hypertension Related Co-Morbidities and Complications in Women of Sub-Saharan Africa: A Brief Review

Hahka,

Slotkowski,

Akbar

et al. 2024

Circulation Research

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“…In addition, SARS-CoV-2 also works as a complement activator (C3, C5), exacerbating symptoms and inducing acute respiratory distress syndrome [224]. The hypercoagulable state associated with COVID-19 is reflected in the increased concentration of coagulation and inflammatory biomarkers (e.g., CRP, Ddimer, fibrinogen, and fibrin degradation products) [225]. Moreover, other mechanisms, including hypoxiainduced injury and endothelial dysfunction, may play a pathogenetic role in the SARS-CoV-2-related CV manifestations [226,227].…”

Section: Pathogenic Mechanismsmentioning

confidence: 99%

Viral infections in cardiometabolic risk and disease between old acquaintances and new enemies

Vassalle

2023

Explor Cardiol

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Atherosclerosis is a chronic disease, characterized by chronic inflammation, endothelial dysfunction, and lipid deposition in the vessel. Although many major, well-identified risk factors for atherosclerosis [e.g., hyperlipidemia, hypertension, type 2 diabetes (T2D), smoking habit, and obesity] explain a lot about the risk, there is a considerable number of patients who develop atherosclerotic damage and undergo adverse events without presenting any of these established modifiable risk factors. This observation has stimulated an urgent need to expand knowledge towards the identification of additional, less established risk factors that may help in the assessment of risk and fill the gap of knowledge in the cardiovascular (CV) setting. Among them, the hypothesis of a possible relationship between viral infectious agents and atherosclerosis has risen since the early 1900s. However, there is still a great deal of debate regarding the onset and progression of CV disease in relation to the roles of the pathogens (as active inducers or bystanders), host genomic counterparts, and environmental triggers, affecting both virus abundance and the composition of viral communities. Accordingly, the aim of this review is to discuss the current state of knowledge on infectious agents in the atherosclerotic process, with particular focus on two environmental-related viruses, as examples of familiar (influenza) and unfamiliar [severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)] disease triggers.

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“…Clinically, non-contact measurements are suited to special cases, such as burn patients, as they do not necessitate direct contact with the wound, thus reducing the risk of infection. Given the emergence of new infectious diseases over the past three years, such as SARS, MERS, and COVID-19 [9][10], patients may experience hypoxia, inflicting damage to blood vessels (endothelial dysfunction or arteriosclerosis), the heart, the autonomic nervous system (as indicated by HRV), and systemic inflammatory response or autoimmune disorder. These conditions are especially noticeable in patients with cardiovascular disease.…”

Section: Introductionmentioning

confidence: 99%

Contactless and Short-Range Vital Signs Detection with Doppler Radar Millimeter-Wave (76 - 81 GHz) Sensing Firmware

Chen

Lin

Zhong

et al. 2023

Preprint

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Vital signs such as heart rate (HR) and respiration rate (RR) are essential physiological parameters used to assess human health and bodily functions. These can be measured via methods that either require or do not require direct contact. A non-contact Doppler radar millimeter (mm)-wave sensing firmware utilizes a 76–81 GHz (W-band) electromagnetic wave over a short-range path to the human body. It then processes the reflected electromagnetic wave to filter and extract human heartbeat and breathing rhythm signals. The short-range sensor system proposed herein eliminates the need for electrodes, electric patches, photoelectric sensors, and conductive wires, as well as the requirement for direct contact with the human body when measuring physiological signals. The W-band Doppler mm-wave sensing firmware, paired with frequency-modulated continuous wave radar, enables continuous monitoring of HR and RR. Short-wavelength mm-waves are employed in short-range detection to deliver highly precise measurements of physiological signals with minimal noise interference. Consequently, experimental tests were conducted in a laboratory setting to measure the heartbeats and breathing rhythm signals of healthy young men. Their HR and RR were estimated through frequency- and time-domain analyses. The experimental results confirm the feasibility of the proposed mm-wave radar for continuous human vital sign detection.

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Endothelial function, arterial stiffness and heart rate variability of patients with cardiovascular diseases hospitalized due to COVID-19

Cited by 10 publications

References 36 publications

Hypertension Related Co-Morbidities and Complications in Women of Sub-Saharan Africa: A Brief Review

Hypertension Related Co-Morbidities and Complications in Women of Sub-Saharan Africa: A Brief Review

Viral infections in cardiometabolic risk and disease between old acquaintances and new enemies

Contactless and Short-Range Vital Signs Detection with Doppler Radar Millimeter-Wave (76 - 81 GHz) Sensing Firmware

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