Endothelial function affects early carotid atherosclerosis progression in hypertensive postmenopausal women

Rossi, Rosario; Nuzzo, Annachiara; Olaru, Alina; Origliani, Giorgia; Modena, Maria Grazia

doi:10.1097/hjh.0b013e328345d950

Cited by 28 publications

(18 citation statements)

References 37 publications

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“…30 FMD is a measure of endothelial function, and impaired FMD, indicative of endothelial dysfunction, appears to link a variety of cardiovascular risk factors with the development 12–13 and progression 31–33 of atherosclerotic vascular disease. Impaired endothelial function is a systemic disease, and forearm endothelial dysfunction correlates with endothelial dysfunction in other vascular beds, including those of the heart.…”

Section: Discussionmentioning

confidence: 99%

Experimental Sleep Restriction Causes Endothelial Dysfunction in Healthy Humans

Calvin

Covassin

Kremers

et al. 2014

JAHA

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BackgroundEpidemiologic evidence suggests a link between short sleep duration and cardiovascular risk, although the nature of any relationship and mechanisms remain unclear. Short sleep duration has also been linked to an increase in cardiovascular events. Endothelial dysfunction has itself been implicated as a mediator of heightened cardiovascular risk. We sought to determine the effect of 8 days/8 nights of partial sleep restriction on endothelial function in healthy humans.Methods and ResultsSixteen healthy volunteers underwent a randomized study of usual sleep versus sleep restriction of two‐thirds normal sleep time for 8 days/8 nights in a hospital‐based clinical research unit. The main outcome was endothelial function measured by flow‐mediated brachial artery vasodilatation (FMD). Those randomized to sleep restriction slept 5.1 hours/night during the experimental period compared with 6.9 hours/night in the control group. Sleep restriction was associated with significant impairment in FMD (8.6±4.6% during the initial pre‐randomization acclimation phase versus 5.2±3.4% during the randomized experimental phase, P=0.01) whereas no change was seen in the control group (5.0±3.0 during the acclimation phase versus 6.73±2.9% during the experimental phase, P=0.10) for a between‐groups difference of −4.40% (95% CI −7.00 to −1.81%, P=0.003). No change was seen in non‐flow mediated vasodilatation (NFMD) in either group.ConclusionIn healthy individuals, moderate sleep restriction causes endothelial dysfunction.Clinical Trial RegistrationURL: ClinicalTrials.gov. Unique identifier: NCT01334788.

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Section: Discussionmentioning

confidence: 99%

Experimental Sleep Restriction Causes Endothelial Dysfunction in Healthy Humans

Calvin

Covassin

Kremers

et al. 2014

JAHA

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“…Cross-sectional studies have shown a correlation between FMD and C-IMT [61,62] and C- IMT progression over a 6-year follow- up in a population free of cardiovascular disease [63] or after 1 year, in hypertensive, postmenopausal women [64]. Impaired FMD has been shown to be an independent predictor of in-stent stenosis after single-vessel coronary interventions [65].…”

Section: Flow-mediated Dilationmentioning

confidence: 99%

Intima media thickness, pulse wave velocity, and flow mediated dilation

Bruno

Bianchini

Faita

et al. 2014

Cardiovasc Ultrasound

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The identification of vascular alterations at the sub-clinical, asymptomatic stages are potentially useful for screening, prevention and improvement of cardiovascular risk stratification beyond classical risk factors.Increased intima-media thickness of the common carotid artery is a well-known marker of early atherosclerosis, which significantly correlates with the development of cardiovascular diseases. More recently, other vascular parameters evaluating both structural and functional arterial proprieties of peripheral arteries have been introduced, for cardiovascular risk stratification and as surrogate endpoints in clinical trials. Increased arterial stiffness, which can be detected by applanation tonometry as carotid-femoral pulse wave velocity, has been shown to predict future cardiovascular events and to significantly improve risk stratification.Finally, earlier vascular abnormalities such as endothelial dysfunction in the peripheral arteries, detected as reduced flow-mediated dilation of the brachial artery, are useful in the research setting and as surrogate endpoints in clinical trials and have also been suggested for their possible clinical use in the future.This manuscript will briefly review clinical evidence supporting the use of these different vascular markers for cardiovascular risk stratification, focusing on the correct methodology, which is a crucial issue to address in order to promote their use in future for routine clinical practice.

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“…Vascular abnormalities have been shown by some [5], but not all [6], to be associated with T2D-related cognitive compromise. A possible explanation for inconsistencies is that vascular abnormalities evolve, with functional typically preceding structural changes [7]. Nevertheless, research usually focuses on structural (primarily MRI), rather than functional assessments of vasculature.…”

Section: Introductionmentioning

confidence: 99%

Arterial Wall Function is Associated with Cognitive Performance Primarily in Elderly with Type 2 Diabetes

Ravona‐Springer

Haratz

Tanné

et al. 2015

JAD

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Regression analyses compared 41 type 2 diabetes (T2D) and 131 non-T2D cognitively normal elderly males on the associations of arterial wall function measures [large artery elasticity index (LAEI), small artery elasticity index (SAEI), systemic vascular resistance (SVR), and total vascular impedance (TVI)] with cognitive performance (memory, language, and executive functions), controlling for socio-demographic and cardiovascular factors. Higher LAEI and lower TVI were significantly associated with better executive functions performance in T2D but not in non-T2D subjects. Lower TVI was more associated with better language performance in T2D. Results suggest that arterial wall function is associated with cognition in T2D.

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Endothelial function affects early carotid atherosclerosis progression in hypertensive postmenopausal women

Cited by 28 publications

References 37 publications

Experimental Sleep Restriction Causes Endothelial Dysfunction in Healthy Humans

Experimental Sleep Restriction Causes Endothelial Dysfunction in Healthy Humans

Intima media thickness, pulse wave velocity, and flow mediated dilation

Arterial Wall Function is Associated with Cognitive Performance Primarily in Elderly with Type 2 Diabetes

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