Endothelial factors in the pathogenesis and treatment of chronic kidney disease Part II

Rossi, Gian Paolo; Seccia, Teresa Maria; Barton, Matthias; Danser, A.H. Jan; Leeuw, Peter W. de; Dhaun, Neeraj; Rizzoni, Damiano; Rossignol, Patrick; Ruilope, Luís M.; Meiracker, Anton H. van den; Ito, Sadayoshi; Hasebe, Naoyuki; Webb, David J.

doi:10.1097/hjh.0000000000001600

Cited by 17 publications

(6 citation statements)

References 133 publications

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“…Structural equation scanning modeling introduces path analysis into hidden variables; at the same time, using the method of factor analysis, the hidden variables and the observed variables are effectively combined and the multivariate statistical analysis method is proposed [ 8 ]. It is an analysis method that combines factor H 0 : F A = F B analysis and path analysis; compared with traditional analysis methods, it can handle the relationship between multiple dependent variables and independent variables at the same time and clarify the relationship structure between factors [ 9 ].…”

Section: Methodsmentioning

confidence: 99%

The Pathogenesis and Influencing Factors of Adult Hypertension Based on Structural Equation Scanning

Feng

et al. 2022

Scanning

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Explore the pathogenesis and influencing factors of adult hypertension based on structural equation scanning. Using a multistage random sampling method, randomly select 2 community health service centers in each administrative area of a certain city and conduct a sample survey of residents in the community. According to the predetermined sample size n , multiply by 1.3 ( 1.3 n ) to draw a sample. Community doctors and medical students who have been uniformly trained form an investigation team draw up a questionnaire by consulting the literature, seek expert opinions, and then make changes based on the questions in the preinvestigation. Experiment result shows that the average systolic blood pressure of the experimental subjects was 126.13 + 15.36 mmHg and the average diastolic blood pressure was 79.52 + 8.81 mmHg ; males are higher than females and increase with age. The prevalence rate of hyperemia is 26.3%, and the prevalence rate of prehypertension among the survey subjects is 55.4%; that of males (62.6%) is higher than that of females (49.2%). The prevalence of isolated systolic hypertension was 7.5%, and that of men (6.9%) was lower than that of women (7.9%). The awareness rate of hypertension was 66.5%, and the treatment rate of hypertension was 62.7%; the control rate of hypertension was 13.2%, and the control rate of hypertension treatment was 25.7%; all the abovementioned rates are higher for women than for men, and they all tend to increase with age which proved that being overweight is a risk factor for hypertension, dyslipidemia, and hypertension. Hypertension, dyslipidemia, and family history of hypertension are risk factors for hypertension. There is a positive correlation between hypertension and dyslipidemia.

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Section: Methodsmentioning

confidence: 99%

The Pathogenesis and Influencing Factors of Adult Hypertension Based on Structural Equation Scanning

Feng

et al. 2022

Scanning

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“…These factors as well as ageing may affect creatinine levels. 28 Thus, whether the elevation of creatinine levels is solely an epiphenomenon induced by the presence of vascular risk factors or is directly associated with these many complications is unclear.…”

Section: Discussionmentioning

confidence: 99%

Coronary Lesions in Patients with Atrial Fibrillation: A Retrospective Study

Chen¹,

Xia²

2021

Exploratory Research and Hypothesis in Medicine

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Background and objectives: This study was performed to determine whether atrial fibrillation (AF) is related to the precise location of a coronary artery lesion. Methods:A single-center retrospective study was conducted to compare data from clinical, laboratory, and instrumental examinations of 89 patients with AF (main group) who were admitted to the department between October 2015 and October 2019. One-hundred-and-sixty patients (comparison group) were selected according to balanced matching.Results: There were no statistically significant differences in low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglycerides (TGs), troponin, or creatine kinase-myocardial band (CK-MB) between the two groups. However, the levels of homocysteine (17.0 ± 1.7 µmol/L vs. 13.7 ± 1.0 µmol/L, p = 0.001), uric acid (342.8 ± 16.7 µmol/L vs. 308.5 ± 15.1 µmol/L, p = 0.003) and creatinine (79.3 ± 4.7 µmol/L vs. 72.9 ± 3.1 µmol/L, p = 0.017) were higher in the AF group compared to the non-AF group. Moreover, the left atrium (LA) diameter (40.2 ± 1.4 mm vs. 33.5 ± 0.8 mm, p = 0.001) was larger in the AF group compared to the non-AF group. Patients with AF compared to those without AF had no significant differences in the degree or location of coronary artery lesions.Conclusions: AF in patients was not associated with specific coronary artery lesions in the current study.

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“…The physiological role of the ET system in the kidney (Figure 3) appears to be dominated by the high expression of ET B Rs primarily, but not exclusively, located in the principal cells within the inner medullary collecting duct (reviewed in [28][29][30] ). In fact, high-salt diets are powerful stimulators of ET-1 production within the kidney tubule and even nonrenal sources of ET-1.…”

Section: Renal Pathophysiological Effects Of Et-1mentioning

confidence: 99%

Endothelin System in Hypertension and Chronic Kidney Disease

Schiffrin,

Pollock

2024

Hypertension

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ET (endothelin) is a powerful vasoconstrictor 21-amino acid peptide present in many tissues, which exerts many physiological functions across the body and participates as a mediator in many pathological conditions. ETs exert their effects through ET A and ET B receptors, which can be blocked by selective receptor antagonists. ETs were shown to play important roles among others, in systemic hypertension, particularly when resistant or difficult to control, and in pulmonary hypertension, atherosclerosis, cardiac hypertrophy, subarachnoid hemorrhage, chronic kidney disease, diabetic cardiovascular disease, scleroderma, some cancers, etc. To date, ET antagonists are only approved for the treatment of primary pulmonary hypertension and recently for IgA nephropathy and used in the treatment of digital ulcers in scleroderma. However, they may soon be approved for the treatment of patients with resistant hypertension and different types of nephropathy. Here, the role of ETs is reviewed with a special emphasis on participation in and treatment of hypertension and chronic kidney disease.

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Endothelial factors in the pathogenesis and treatment of chronic kidney disease Part II

Cited by 17 publications

References 133 publications

The Pathogenesis and Influencing Factors of Adult Hypertension Based on Structural Equation Scanning

The Pathogenesis and Influencing Factors of Adult Hypertension Based on Structural Equation Scanning

Coronary Lesions in Patients with Atrial Fibrillation: A Retrospective Study

Endothelin System in Hypertension and Chronic Kidney Disease

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