Endothelial Endothelin Receptor A Expression Is Associated With Podocyte Injury and Oxidative Stress in Patients With Focal Segmental Glomerulosclerosis

Abstract

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Minimal Change Disease Is Associated With Endothelial Glycocalyx Degradation and Endothelial Activation

“… 9 In fact, an increase in endothelin receptor A expression and oxidative stress in GEnC has been reported in patients with focal segmental glomerulosclerosis and diabetic nephropathy. 37 , 38 , 39 Therefore, sustained endothelial alterations may identify patients with MCD/SSNS at risk for progression to focal segmental glomerulosclerosis or advanced stages of chronic kidney disease.…”

Diverse Alterations of Glomerular Capillary Networks in Focal Segmental Glomerular Sclerosis

“…This was associated with nephrin loss and increased 8-oxoguanine positive staining, a DNA lesion caused by oxidative damage, and increased proteinuria levels. 18 Taneda et al used electron micrographs of FSGS renal biopsies to measure subendothelial widening as a marker for endothelial cell injury. They reported that this widening was associated with poor remission rates and decreased estimated glomerular filtration rate (eGFR).…”

“…Van de Lest et al. 18 showed increase in glomeruli with endothelin receptor A-positive ECs in 39 FSGS biopsy specimens. This was associated with nephrin loss and increased 8-oxoguanine–positive staining, a DNA lesion caused by oxidative damage, and increased proteinuria levels.…”

“…This was associated with nephrin loss and increased 8-oxoguanine–positive staining, a DNA lesion caused by oxidative damage, and increased proteinuria levels. 18 Taneda et al. 19 used electron micrographs of FSGS renal biopsy specimens to measure subendothelial widening as a marker for EC injury.…”

Clues to Glomerular Cell Chatter in Focal Segmental Glomerulosclerosis: Via Endothelin-1/ETR

“…Endothelin receptor antagonists have been evaluated in patients with proteinuric glomerular diseases including diabetic kidney disease and FSGS, and have demonstrated encouraging anti-proteinuric effects and to stabilize kidney function. In this issue of KI Reports, van de Lest, et al performed a retrospective study to examine the expression of ET A R in biopsy samples of patients with FSGS by immunohistochemistry and immunofluorescence analysis "in press 4 ". The authors compared 39 kidney biopsies from patients with idiopathic FSGS to 8 controls obtained from deceased donors, and found that there was significantly higher numbers of glomeruli staining positive for ET A R among the FSGS cases, and ET A R was shown to be co-localized with endothelial cell marker CD31.…”