Endothelial Dysfunction Under Influence of Ionizing Radiation: Pathogenetic Basis and Opportunities of Pharmacological Correction

Abstract

The problem of radiation-induced lesions is becoming increasingly urgent. Studies in recent years show that one of the most vulnerable tissues is the endothelium when exposed to high doses of ionizing radiation. The study of the pathogenetic bases of this phenomenon has shown that damage to endotheliocytes occurs both at the expense of the direct exposure to radiation and due to the systemic disturbance of homeostasis which leads to the disadaptation of the executive and regulatory systems of the organism. In this review we considered the mechanisms of the development of endothelial dysfunction under the influence of radioactive radiation and possible methods of pharmacological correction of this condition.

Mafusol and its combination with REXOD as correctors of reduced blood circulation in the skin associated with normoglycemia or diabetes mellitus complicated by exogenous hypercholesterolemia

“…Taking into account the above, for our study we chose the drugs mafusol and rexod. The first one contains fumaric acid, which is part of the Krebs cycle and ensures the maintenance of energy processes in tissues at the appropriate level (Strakhov 2016;Sukhomlin et al 2016;Maevsky and Grishina 2017;Sukhomlin et al 2017); the second one, which is a recombinant human superoxide dismutase (SOD), is the first line enzyme of defense against free radicals and also has a pronounced anti-inflammatory, anti-hypoxic, cytotropic and membrane tropic activities (Shakhmardanova et al 2016;Jiang et al 2017;Biosa et al 2018;Nguyen et al 2018;Saroyan et al 2018;Shafranova et al 2018;Srivastava et al 2018;Wang et al 2018;Yoon et al 2018;Shi et al 2019;Leontev et al 2020).…”