Endothelial dysfunction of internal thoracic artery graft in patients with chronic kidney disease

Kinoshita, Takeshi; Tawa, Masashi; Suzuki, Tomoaki; Aimi, Yoshinari; Asai, Tomohiro; Okamura, Tomio

doi:10.1016/j.jtcvs.2016.09.037

Cited by 9 publications

(9 citation statements)

References 32 publications

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“…Kidney function expressed as eGFR also emerged as clinical predictor of intimal hyperplasia (odds ratio = 1.03). Although such association must be carefully interpreted due to the non-significant result (P = 0.059), this result is not in accordance with recent reports by Kinoshita et al who showed that chronic kidney disease defined by a decreased eGFR at the time of surgery is associated both with intimal hyperplasia [24] and endothelial dysfunction [36].…”

Section: Discussioncontrasting

confidence: 56%

Histomorphometric analysis of the human internal thoracic artery and relationship with cardiovascular risk factors

Fonseca

Antunes

et al. 2019

PLoS ONE

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In this study, we aimed at performing a histomorphometric analysis of human left internal thoracic artery (ITA) samples as well as at correlating the histomorphometric findings with the clinical profile, including risk factors and medication. Distal segments of ITA were obtained from 54 patients undergoing coronary artery bypass grafting. Histological observation was performed in paraffin-embedded transverse sections of ITA through four staining protocols: hematoxylin-eosin, van Gieson, Masson’s trichrome and von Kossa. Morphometric analysis included the intimal width (IW), medial width (MW) and intima/media ratio (IMR). No overt atherosclerotic lesions were observed. Mild calcifications were observed across the vascular wall layers in almost all samples. Multivariable linear regression analysis showed associations between IW and IMR and the following clinical variables: age, gender, kidney function expressed as eGFR and myocardial infarction history. Age (odds ratio = 1.16, P = 0.004), female gender (odds ratio = 11.34, P = 0.011), eGFR (odds ratio = 1.03, P = 0.059) and myocardial infarction history (odds ratio = 4.81, P = 0.040) were identified as the main clinical predictors for intimal hyperplasia. Preatherosclerotic lesions in ITA samples from patients undergoing coronary revascularization were associated not only with classical cardiovascular risk factors such as age and gender, but also with other clinical variables, namely kidney function and myocardial infarction history.

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Section: Discussioncontrasting

confidence: 56%

Histomorphometric analysis of the human internal thoracic artery and relationship with cardiovascular risk factors

Fonseca

Antunes

et al. 2019

PLoS ONE

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“…Concerning eGFR, Kinoshita et al (2017) recently showed that the ITA endothelial function with release of nitric oxide may be impaired at the time of surgery in patients with chronic kidney disease, suggesting a potential impact of this clinical setting on the peripheral vasculature. Moreover, this research group has also shown that chronic kidney disease may be associated with intimal hyperplasia of the ITA (Kinoshita, Asai, Suzuki, & Van Phung, 2014).…”

Section: Discussionmentioning

confidence: 99%

Vasomotion as an oscillatory sign of functional impairment in the human internal thoracic artery: A study based on risk factors and vessel reactivity

Fonseca

Antunes

et al. 2018

Experimental Physiology

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Vasomotion has been defined as the rhythmic oscillation of the vascular tone, involved in the control of the blood flow and subsequent tissue perfusion. Our aims were to study the incidence of vasomotion in the human internal thoracic artery and the correlation of this phenomenon with the clinical profile and parameters of vascular reactivity. In our study, vasomotion was elicited with a single-dose contractile stimulation of noradrenaline (10 μm) in internal thoracic artery segments, from patients undergoing coronary artery bypass grafting, mounted in tissue organ bath chambers. The incidence was 29.1%. Vessel samples with vasomotion presented significantly higher contractility in response to both potassium chloride (maximal response or E of 7.65 ± 5.81 mN versus 4.52 ± 3.73 mN in control vessels, P = 0.024) and noradrenaline (E of 7.60 ± 5.93 mN versus 2.96 ± 4.41 mN in control vessels, P < 0.001). Predictive modelling through multivariable logistic regression analysis showed that female sex (odds ratio = 9.82) and increasing maximal response to noradrenaline (odds ratio = 1.19, per 1 mN increase) were associated with a higher probability of the occurrence of vasomotion, whereas increasing kidney function (expressed as estimated glomerular filtration rate) was associated with a lower probability (odds ratio = 0.97, per 1 ml min (1.73 m) ]. Our results provide a characterization of the phenomenon of vasomotion in the internal thoracic artery and suggest that vasomotion might be associated with endothelial dysfunction settings, as determined by a multivariable analysis approach. Considering the associations observed in our results, vasomotion might be a signal of functional impairment and not of integrity.

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confidence: 99%

“…In their article in this issue of the Journal, Kinoshita and colleagues 12 add evidence that endothelial dysfunction may play a significant role in the progression of arterial graft failure. Specifically, under inhibition of cyclooxygenase with indomethacin, Kinoshita and colleagues 12 found that acetylcholine produced a concentration-dependent relaxation in patients with an eGFR greater than 60 mL/min/1.73 m 2 . This relaxation was less evident in patients with an eGFR between 30 and 60 mL/min/1.73 m 2 , whereas a mild contraction was observed in patients with severe CKD (eGFR <30 mL/min/1.73 m 2 ), suggesting that nitric oxide was not produced by the endothelium.…”

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Endothelial dysfunction or anything else?

Miceli

2017

The Journal of Thoracic and Cardiovascular Surgery

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Endothelial dysfunction of internal thoracic artery graft in patients with chronic kidney disease

Abstract: Endothelial function of ITA grafts to release NO is impaired at the time of surgery in patients with chronic kidney disease.

Cited by 9 publications

References 32 publications

Histomorphometric analysis of the human internal thoracic artery and relationship with cardiovascular risk factors

Histomorphometric analysis of the human internal thoracic artery and relationship with cardiovascular risk factors

Vasomotion as an oscillatory sign of functional impairment in the human internal thoracic artery: A study based on risk factors and vessel reactivity

Endothelial dysfunction or anything else?

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