Endothelial dysfunction of cerebral and major arteries during chronic obstructive disease

Гельцер, Б. И.; Brodskaya, T. A.; Kotelnikov, V. N.; Агафонова, И. Г.; Lukyanov, Pavel

doi:10.1007/s10517-007-0427-x

Cited by 10 publications

(8 citation statements)

References 4 publications

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“…We did not find evidence of chronic cerebrovascular dilation in COPD patients. Our results are supported in both an animal model [22], and hypercapnic patients with severe COPD [6]. Cigarette smoking is known to induce both acute and chronic cerebrovascular dilation in healthy individuals, but cerebrovascular reactivity appears to be maintained.…”

Section: Physiological Response To Hypercapniasupporting

confidence: 74%

Decreased cerebrovascular response to CO₂in post-menopausal females with COPD: role of oxidative stress

Hartmann¹,

Pialoux²,

Leigh³

et al. 2012

Eur Respir J

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Chronic obstructive pulmonary disease (COPD) is associated with cerebrovascular abnormalities and an overproduction of reactive oxygen species. We hypothesised that COPD patients have oxidant-related cerebrovascular dysfunction. Our main objective was to evaluate cerebrovascular reactivity and its relationship with oxidative stress in females with COPD.We studied eight females with moderate COPD and 10 healthy female control subjects of similar age. Transcranial Doppler ultrasound assessed cerebral blood flow (CBF) velocity during hypercapnia. Plasma was assessed at rest for DNA oxidation, advanced oxidation protein products, lipid peroxidation, nitrotyrosine, antioxidant enzyme activity (glutathione peroxidase and catalase) and end-products of nitric oxide metabolism.Moderate COPD patients showed decreased cerebrovascular sensitivity to carbon dioxide (CO 2 ) (COPD 1.17¡0.54 versus control 2.15¡0.73 cm?s -1 ?mmHg -1 ; p,0.01). COPD patients had higher levels of DNA and lipid oxidation, advanced oxidation protein products and higher glutathione peroxidase activity (p,0.05). Controlling for measures of oxidative stress (DNA and lipid oxidation, and advanced oxidation protein product) eliminates statistically significant differences between the COPD and control groups in the CBF sensitivity to CO 2 . Females with moderate COPD were found to have cerebrovascular dysfunction. Our results suggest that increased levels of systemic oxidative stress may have implications in the cerebrovascular dysfunction observed during hypercapnia in COPD.

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Section: Physiological Response To Hypercapniasupporting

confidence: 74%

Decreased cerebrovascular response to CO₂in post-menopausal females with COPD: role of oxidative stress

Hartmann¹,

Pialoux²,

Leigh³

et al. 2012

Eur Respir J

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“…For example, in an experimental model of COPD, activation of endothelial-dependent dilator pathways paradoxically leads to constriction of cerebral vessels (e.g. middle cerebral artery), indicative of endothelial dysfunction [ 164 ]. However, the roles of inflammation and oxidative stress in this dysfunction were not examined.…”

Section: Potential Mechanisms Linking Copd and Stroke Riskmentioning

confidence: 99%

COPD and stroke: are systemic inflammation and oxidative stress the missing links?

et al. 2016

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Chronic obstructive pulmonary disease (COPD) is characterized by progressive airflow limitation and loss of lung function, and is currently the third largest cause of death in the world. It is now well established that cardiovascular-related comorbidities such as stroke contribute to morbidity and mortality in COPD. The mechanisms linking COPD and stroke remain to be fully defined but are likely to be interconnected. The association between COPD and stroke may be largely dependent on shared risk factors such as aging and smoking, or the association of COPD with traditional stroke risk factors. In addition, we propose that COPD-related systemic inflammation and oxidative stress may play important roles by promoting cerebral vascular dysfunction and platelet hyperactivity. In this review, we briefly discuss the pathogenesis of COPD, acute exacerbations of COPD (AECOPD) and cardiovascular comorbidities associated with COPD, in particular stroke. We also highlight and discuss the potential mechanisms underpinning the link between COPD and stroke, with a particular focus on the roles of systemic inflammation and oxidative stress.

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“…В Дальневосточном регионе у населения часто встречается хроническая обструктивная болезнь легких [1], одним из грозных осложнений которой является легочная гипертензия [2]. В патогенезе повышения давления в системе легочной артерии ключевую роль играет воздействие медиаторов системного воспаления на эндотелиоциты, участвующие в выработке вазоконстрикторов, и на морфологические структуры стенки кровеносных сосудов [3][4][5][6]. В снижении частоты развития хронических заболеваний легких важное значение имеет онтогенетический подход, позволяющий установить факторы риска нарушения гемодинамических процессов в сосудах малого круга кровообращения у новорожденных с отягощенным внутриутробным развитием [7].…”

Section: оригинальные исследованияunclassified

Immunomorphological assessment of the systemic inflammatory response in newborns with congenital cytomegalovirus infection

Andrievskaya

Gorikov

Сомова³

et al. 2020

Bûlletenʹ fiziologii i patologii dyhaniâ

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Контактная информацияИгорь Николаевич Гориков, канд. мед. наук, старший научный сотрудник, лаборатория механизмов этиопатогенеза и восстановительных процессов дыхательной системы при неспецифических заболеваниях легких, Федеральное государственное бюджетное научное учреждение «Дальневосточный научный центр физиологии и патологии дыхания, 675000, Россия, г. Благовещенск, ул. Калинина, 22.

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Endothelial dysfunction of cerebral and major arteries during chronic obstructive disease

Cited by 10 publications

References 4 publications

Decreased cerebrovascular response to CO₂in post-menopausal females with COPD: role of oxidative stress

Decreased cerebrovascular response to CO₂in post-menopausal females with COPD: role of oxidative stress

COPD and stroke: are systemic inflammation and oxidative stress the missing links?

Immunomorphological assessment of the systemic inflammatory response in newborns with congenital cytomegalovirus infection

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Endothelial dysfunction of cerebral and major arteries during chronic obstructive disease

Cited by 10 publications

References 4 publications

Decreased cerebrovascular response to CO2in post-menopausal females with COPD: role of oxidative stress

Decreased cerebrovascular response to CO2in post-menopausal females with COPD: role of oxidative stress

COPD and stroke: are systemic inflammation and oxidative stress the missing links?

Immunomorphological assessment of the systemic inflammatory response in newborns with congenital cytomegalovirus infection

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Product

Resources

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Decreased cerebrovascular response to CO₂in post-menopausal females with COPD: role of oxidative stress

Decreased cerebrovascular response to CO₂in post-menopausal females with COPD: role of oxidative stress