Endothelial dysfunction is associated with the severity of cerebral small vessel disease

Nezu, Tomohisa; Hosomi, Naohisa; Aoki, Shiro; Kubo, Shunsuke; Araki, Mutsuko; Mukai, Tomoya; Takahashi, Tetsuya; Makino, Hírofumi; Higashi, Yukihito; Matsumoto, Masayasu

doi:10.1038/hr.2015.4

Cited by 62 publications

(49 citation statements)

References 43 publications

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“…The pathogenesis of cerebral small vessel disease, which involves white matter lesions (WMLs) and cerebral microbleeds (CMBs), is thought to be associated with endothelial dysfunction [42, 43]. …”

Section: Discussionmentioning

confidence: 99%

Arterial stiffness, endothelial and cognitive function in subjects with type 2 diabetes in accordance with absence or presence of diabetic foot syndrome

Tuttolomondo

Casuccio

Guercio

et al. 2017

Cardiovasc Diabetol

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BackgroundEndothelial dysfunction is an early marker of cardiovascular disease so endothelial and arterial stiffness indexes are good indicators of vascular health. We aimed to assess whether the presence of diabetic foot is associated with arterial stiffness and endothelial function impairment.MethodsWe studied 50 subjects with type 2 diabetes mellitus and diabetic foot syndrome (DFS) compared to 50 diabetic subjects without diabetic foot, and 53 patients without diabetes mellitus, by means of the mini mental state examination (MMSE) administered to evaluate cognitive performance. Carotid-femoral pulse wave velocity (PWV) and augmentation index (Aix) were also evaluated by Applanation tonometry (SphygmoCor version 7.1), and the RH-PAT data were digitally analyzed online by Endo-PAT2000 using reactive hyperemia index (RHI) values.ResultsIn comparison to diabetic subjects without diabetic foot the subjects with diabetic foot had higher mean values of PWV, lower mean values of RHI, and lower mean MMSE. At multinomial logistic regression PWV and RHI were significantly associated with diabetic foot presence, whereas ROC curve analysis had good sensitivity and specificity in arterial PWV and RHI for diabetic foot presence.ConclusionsPulse wave velocity and augmentation index, mean RHI values, and mean MMSE were effective indicators of diabetic foot. Future research could address these issues by means of longitudinal studies to evaluate cardiovascular event incidence in relation to arterial stiffness, endothelial and cognitive markers.

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Section: Discussionmentioning

confidence: 99%

Arterial stiffness, endothelial and cognitive function in subjects with type 2 diabetes in accordance with absence or presence of diabetic foot syndrome

Tuttolomondo

Casuccio

Guercio

et al. 2017

Cardiovasc Diabetol

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“…In addition to the correlation between PAT and the ABI value, we also demonstrated a correlation between the PAT test and CVD. Nezu et al [23] reported that FMD < 4% was significantly correlated with CVD, including cerebral microbleeding. The findings from our study might support a significant correlation between PAT and CVD, as with FMD.…”

Section: Discussionmentioning

confidence: 99%

Endothelial Dysfunction of Patients with Peripheral Arterial Disease Measured by Peripheral Arterial Tonometry

Igari

Kudo

Toyofuku

et al. 2016

International Journal of Vascular Medicine

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Objective. Endothelial dysfunction plays a key role in atherosclerotic disease. Several methods have been reported to be useful for evaluating the endothelial dysfunction, and we investigated the endothelial dysfunction in patients with peripheral arterial disease (PAD) using peripheral arterial tonometry (PAT) test in this study. Furthermore, we examined the factors significantly correlated with PAT test. Methods. We performed PAT tests in 67 patients with PAD. In addition, we recorded the patients' demographics, including comorbidities, and hemodynamical status, such as ankle brachial pressure index (ABI). Results. In a univariate analysis, the ABI value (r = 0.271, P = 0.029) and a history of cerebrovascular disease (r = 0.208, P = 0.143) were found to significantly correlate with PAT test, which calculated the reactive hyperemia index (RHI). In a multivariate analysis, only the ABI value significantly and independently correlated with RHI (β = 0.254, P = 0.041). Conclusion. This study showed a significant correlation between RHI and ABI. The PAT test is a useful tool for evaluating not only endothelial dysfunction but also the hemodynamical state in patients with PAD.

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“…With the coming of the aging society and the popularization of head MRI, the detection rate of WML is getting higher and higher. The etiology of WML may be related to endothelial dysfunction, chronic cerebral hypoperfusion, blood-brain barrier destruction, and auto-regulatory dysfunction of small vessels [10,15].…”

Section: Discussionmentioning

confidence: 99%

Correlations between plasma homocysteine and MTHFR gene polymorphism and white matter lesions

Li¹,

Fu²,

Dong³

2018

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This study aims to investigate the correlation between the plasma homocysteine (Hcy) level and methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism, and white matter lesions (WML). The plasma Hcy level and MTHFR C677T gene polymorphism in 104 patients with white matter lesions and 74 controls were measured. The severity of cerebral white matter was scored on the magnetic resonance imaging (MRI) images by the modified Scheltens scale (score of 0-30). The plasma Hcy level in the WML group was remarkably higher than that in the control group (p < 0.05), and the proportion of the patients with a high Hcy level in the WML group was notably higher than that in the control group (p < 0.05). Moreover, the patients with TT genotype in MTHFR gene had a significantly higher plasma Hcy level than those with CT or CC genotype. In addition, the plasma Hcy level in the patients with CT genotype was also significantly different from that in the patients with CC genotype (p < 0.05). The severity of cerebral white matter lesions among the patients with different genotypes in MTHFR gene was not significantly different (p > 0.05). The plasma Hcy level is positively correlated with WML and significantly correlated with C677T gene polymorphism in MTHFR gene. The severity of white matter lesions is not correlated with MTHFR C677T gene polymorphism.

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Endothelial dysfunction is associated with the severity of cerebral small vessel disease

Cited by 62 publications

References 43 publications

Arterial stiffness, endothelial and cognitive function in subjects with type 2 diabetes in accordance with absence or presence of diabetic foot syndrome

Arterial stiffness, endothelial and cognitive function in subjects with type 2 diabetes in accordance with absence or presence of diabetic foot syndrome

Endothelial Dysfunction of Patients with Peripheral Arterial Disease Measured by Peripheral Arterial Tonometry

Correlations between plasma homocysteine and MTHFR gene polymorphism and white matter lesions

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