Endothelial dysfunction is associated with increased levels of biomarkers in essential hypertension

Sierra, Alejandro de la; Larrousse, María

doi:10.1038/jhh.2009.91

Cited by 59 publications

(35 citation statements)

References 34 publications

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“…A previous study reported that the urine levels of 8-OHdG decreased after treatment in the ARB group, but did not decrease in the non-ARB group in hypertensive patients [15]. MDA and 4-HNE, the secondary products of lipid peroxidation, are involved in lipid-related oxidative stress, which leads to vascular injury in hypertension [21,22].…”

Section: Measurements Of Serum Estradiol and Testosteronementioning

confidence: 96%

Effect of felodipine with irbesartan or metoprolol on sexual function and oxidative stress in women with essential hypertension

et al. 2012

Journal of Hypertension

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Section: Measurements Of Serum Estradiol and Testosteronementioning

confidence: 96%

Effect of felodipine with irbesartan or metoprolol on sexual function and oxidative stress in women with essential hypertension

et al. 2012

Journal of Hypertension

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“…Since NO has the ability to inhibit the expression of MCP-1, in endothelial dysfunction MCP-1 and leukocyte migration are activated, increasing inflammation in the vascular wall. elevated concentrations of MCP-1 have been described in patients with essential hypertension and endothelial dysfunction [44]. asymmetric dimethylarginine (adMa) is an endogenous inhibitor of NO synthase which, through a reduction in its bioavailability, can lead to endothelial dysfunction.…”

Section: Chemokines and Endothelial Dysfunctionmentioning

confidence: 99%

The Role of Chemokines in Hypertension

Martynowicz¹,

Janus²,

Nowacki³

et al. 2014

Adv Clin Exp Med

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Hypertension is a major risk factor for cardiovascular disease, which is a serious health problem in the highly industrialized countries. In more than 95% of the cases, the etiology of hypertension remains unknown. a key role in the etiology of hypertension is played by endothelial dysfunction and the inflammatory reaction in the vascular wall, in which the low molecular weight proteins -so-called chemokines -are involved. The chemokines involved in the pathogenesis of hypertension include monocyte chemoattractant protein-1, MCP-1, CCL2, interferon--inducible protein (IP-10; CXCL10), interleukin-8 (IL-8; CXCL8), RaNTeS (CCL5), fractalkine (CX3CL1) and their receptors CCR2, CCR5, CXCR1, CXCR2, CXCR3 and CX3CR1. The mechanisms involving chemokines and their receptors in the pathogenesis of hypertension are complex and not fully understood. They include the impact of the migration of macrophages and monocytes to the vascular wall, endothelial dysfunction, effects on nitric oxide and endothelin-1 and smooth muscle cell proliferation. Chemokines are also involved in the pathogenesis of complications of hypertension, such as atherosclerosis, myocardial and renal fibrosis. Hypertension is one of the most important risk factors for cardiovascular diseases. In Poland, cardiovascular diseases pose a major medical, economic and social problem. The prevalence of hypertension in Poland reaches 32% of the adult population, but only one in three Poles suffering from hypertension is aware of the disease [1]. In more than 95% of the cases, the etiology of essential hypertension remains unknown. a significant role in the pathogenesis of hypertension is played by genetic factors regulating the transport of ions and water, renal hemodynamics and the function of numerous hormones such as aldosterone, catecholamines, renin, vasopressin and endothelin-1 (eT-1). The level of blood pressure depends on the interplay of numerous systems and factors such as the renin-angiotensin-aldosterone system (RaaS), the sympathetic nervous system, natriuretic peptides and the vascular endothelium. blood pressure level is also affected by factors such as sodium intake, low physical activity, stress and obesity. In recent years, attention has been paid to the participation of inflammatory factors in the etiology of hypertension leading to endothelial dysfunction, which in turn plays a key role in the pathogenesis of hypertension. Low molecular weight proteins of the cytokine family which have the ability to stimulate and control leukocyte migration -so-called chemokines -participate in the inflammatory reaction involving the vascular wall. These proteins have the ability to bind to receptors associated with 7-transdomain G proteins; however, most chemokines bind to more than one receptor, and the receptors are capable of binding more than one * dorian Nowacki's doctoral scholarship is co-financed by the european Union as part of the european Social fund.

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“…Two main adverse clinical consequences of OxS are endothelial dysfunction and left ventricular hypertrophy [175]. Therefore, new strategies in reversing both these adverse conditions by targeting OxS by novel means are promising ways to improve the prognosis of CKD patients.…”

Section: Renal Function and Oxsmentioning

confidence: 99%

Evaluation of the Possible Contribution of Antioxidants Administration in Metabolic Syndrome

Haidara¹,

Mikhailidis²,

Yassin³

et al. 2011

CPD

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The metabolic syndrome (MetS) is common, and its associated risk burdens of diabetes and cardiovascular disease (CVD) are a major public health problem. The hypothesis that main constituent parameters of the MetS share common pathophysiologic mechanisms provides a conceptual framework for the future research. Exercise and weight loss can prevent insulin resistance and reduce the risk of diseases associated with the MetS. Interrupting intracellular and extracellular reactive oxygen species (ROS) overproduction could also contribute to normalizing the activation of metabolic pathways leading to the onset of diabetes, endothelial dysfunction, and cardiovascular (CV) complications. On the other hand, it is difficult to counteract the development of CV complications by using conventional antioxidants. Indeed, interest has focused on strategies that enhance the removal of ROS using either antioxidants or drugs that enhance endogenous antioxidant defense. Although these strategies have been effective in laboratory experiments, several clinical trials have shown that they do not reduce CV events, and in some cases antioxidants have actually worsened the outcome. More research is needed in this field.

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Endothelial dysfunction is associated with increased levels of biomarkers in essential hypertension

Cited by 59 publications

References 34 publications

Effect of felodipine with irbesartan or metoprolol on sexual function and oxidative stress in women with essential hypertension

Effect of felodipine with irbesartan or metoprolol on sexual function and oxidative stress in women with essential hypertension

The Role of Chemokines in Hypertension

Evaluation of the Possible Contribution of Antioxidants Administration in Metabolic Syndrome

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