Endothelial dysfunction in young patients with long-term rheumatoid arthritis and low disease activity

Hänsel, Sven; Lässig, Grit; Pistrosch, Frank; Passauer, Jens

doi:10.1016/s0021-9150(03)00281-8

Cited by 104 publications

(68 citation statements)

References 15 publications

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“…The loss of protective antioxidant and anti-inflammatory mechanisms seems to be responsible for the endothelial dysfunction which is the earliest, but yet reversibile, stage of atherosclerotic plaque formation (Deanfieldet et al, 2007). Supporting this hypothesis, endothelial dysfunction has been found also in young RA patients without traditional cardiovascular risk factors (Hansel et al, 2003), thus suggesting the involvement of disease-related mechanisms.…”

Section: Epcs In Ramentioning

confidence: 77%

Endothelial progenitor cells: Are they displaying a function in autoimmune disorders?

Ferrante

Guggino

Liberto

et al. 2016

Mechanisms of Ageing and Development

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a b s t r a c tEndothelial Progenitor Cells (EPCs) are bone marrow derived cells able to differentiate in mature endothelial cells (EC) contributing to the generation of new vessels, connecting to fibronectin, and forming colonies and/or colony forming units.Since circulating EPCs can be actively considered part of endothelial damage in several cardiovascular diseases and autoimmune disorders the possibility to have a measure for endothelium damage should be considered of interest to predict the patient out-come. At the same time the EPCs proliferative and regenerative role could be considered for therapeutic applications.

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Section: Epcs In Ramentioning

confidence: 77%

Endothelial progenitor cells: Are they displaying a function in autoimmune disorders?

Ferrante

Guggino

Liberto

et al. 2016

Mechanisms of Ageing and Development

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“…Their study did not demonstrate any difference in endothelial function between RA patients and controls. Several other studies (28,29) have shown the presence of endothelial dysfunction in RA patients. It is important that in these studies, an invasive assessment of endothelial function was applied.…”

Section: Discussionmentioning

confidence: 92%

The influence of mean blood pressure on arterial stiffening and endothelial dysfunction in women with rheumatoid arthritis and systemic lupus erythematosus

et al. 2010

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“…Endothelial dysfunction was deteriorated to a similar extent in patients with systemic and nonsystemic JIA. Impaired FMD has been consistently observed in adult patients with CID, such as rheumatoid arthritis (11,13), as well as in children with Kawasaki disease (23), a systemic vasculitis that occurs mainly in younger ages. Recently, no difference in FMD between children/adolescents with systemic lupus erythematosus and healthy controls (24,25) was reported.…”

Section: Discussionmentioning

confidence: 99%

“…In adult populations with CID, indices of subclinical atherosclerosis have been well documented (10 -12) and related to worse cardiovascular prognosis (1,12). In patients with CID, vascular dysfunction appears to occur at a relatively young age (13,14). However, there are limited data on indices of premature atherosclerosis (15,16) in patients with JIA.…”

Section: Introductionmentioning

confidence: 99%

Changes in vascular function and structure in juvenile idiopathic arthritis

Vlahos¹,

Theocharis²,

Bechlioulis³

et al. 2011

Arthritis Care & Research

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Objective. Chronic inflammatory diseases in adults have been associated with increased cardiovascular risk and impaired vascular function. We aimed to assess the presence of early vascular dysfunction in patients with juvenile idiopathic arthritis (JIA) and investigate the role of inherent inflammatory process of JIA in vascular health. Methods. Thirty patients with JIA (age range 7-18 years) were compared to 33 age-and sex-matched controls. Endothelial function (brachial artery flow-mediated dilation [FMD]), carotid intima-media thickness (IMT), and arterial stiffness were examined. Endothelial inflammation was assessed by intercellular adhesion molecule 1 (ICAM-1) and P-selectin measurements. Results. Patients with JIA showed decreased FMD compared to controls (P ‫؍‬ 0.001), independent of age (P ‫؍‬ 0.9 among age subgroups). Baseline differences in erythrocyte sedimentation rate, ICAM-1, and glucose between the 2 groups accounted for the difference in FMD. The presence of systemic JIA was associated with greater IMT compared to patients with oligoarticular disease, polyarticular disease, or controls (P ‫؍‬ 0.014, P ‫؍‬ 0.069, and P ‫؍‬ 0.046, respectively). The difference in IMT between systemic versus oligoarticular/polyarticular JIA was attributed to the following risk factors: age, body mass index, blood pressure, disease activity, and corticosteroids use. There were no differences in arterial stiffness indices between JIA patients and controls or between patients with systemic versus nonsystemic disease. Conclusion. Endothelial function is impaired in patients with JIA at a very young age, while IMT is increased only in the presence of systemic JIA. Vascular dysfunction may be partly attributed to the effects of disease-related characteristics (inflammation, disease activity, and medications).

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Endothelial dysfunction in young patients with long-term rheumatoid arthritis and low disease activity

Cited by 104 publications

References 15 publications

Endothelial progenitor cells: Are they displaying a function in autoimmune disorders?

Endothelial progenitor cells: Are they displaying a function in autoimmune disorders?

The influence of mean blood pressure on arterial stiffening and endothelial dysfunction in women with rheumatoid arthritis and systemic lupus erythematosus

Changes in vascular function and structure in juvenile idiopathic arthritis

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