Endothelial dysfunction in the early stage of atherosclerosis precedes appearance of intimal lesions assessable with intravascular ultrasound

Mano, Toshiaki; Masuyama, Tohru; Yamamoto, Kazuhide; Naito, Junko; Kondo, Hiroya; Nagano, Reiko; Tanouchi, Jun; Hori, Masatsugu; Inoue, Michitoshi; Kamada, Takenobu

doi:10.1016/s0002-8703(96)90346-4

Cited by 113 publications

(60 citation statements)

References 33 publications

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“…17 Endothelial dysfunction assessed based on the changes in either peripheral vascular resistance or the vessel diameter during acetylcholine administration has been used as a sensitive marker of atherosclerosis. 18,19 In our study, we found that in patients with HCM, endothelial-dependent or independent vasodilatation did not differ from that observed in healthy subjects. Furthermore, there were no significant differences in plasma cholesterol (181±14, 192±18 mg/dl, respectively, p=NS), age and basal peripheral vascular resistance between healthy subjects and the patients with HCM.…”

Section: Desensitization Of Vascular Adrenoceptorssupporting

confidence: 39%

Impaired Peripheral Vasoconstriction in Response to Alpha-Adrenergic Stimulation in Patients With Idiopathic Hypertrophic Cardiomyopathy

et al. 1998

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Section: Desensitization Of Vascular Adrenoceptorssupporting

confidence: 39%

Impaired Peripheral Vasoconstriction in Response to Alpha-Adrenergic Stimulation in Patients With Idiopathic Hypertrophic Cardiomyopathy

et al. 1998

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“…Endothelial dysfunction, especially impaired endothelium-dependent vasodilatation, has been linked to the pathogenesis of atherosclerotic vascular disease and acute cardiovascular events. Furthermore, reduced endothelial vasodilator function occurs early in atherogenesis before histological and angiographic evidence of arteriosclerosis (Mano et al 1996).…”

Section: Discussionmentioning

confidence: 99%

Endothelial Flow-Mediated Dilatation and Exercise Capacity in Highly Trained Endurance Athletes

Kaşıkçıoğlu

Oflaz

Kaşıkçıoğlu

et al. 2005

Tohoku J. Exp. Med.

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Brachial artery ultrasound during reactive hyperemia is a noninvasive method of assessing peripheral endothelium-dependent vasodilatation. Aerobic exercise has the potential to improve local endothelial function. We sought to analyze the effects of regular aerobic training on brachial artery endothelial function in endurance athletes. We studied diameter and blood flow of the brachial artery in 32 endurance male athletes and 30 healthy male subjects. In the same subjects flow-mediated dilatation of the brachial artery was recorded by inducing an ischemia through a forearm arterial occluding cuff. Maximal oxygen consumption was significantly higher in the athletes group than in the controls (61.24 ± 5.43 vs 44.49 ± 2.68 ml/kg/min, p < 0.001). Flow-mediated dilatation of the brachial artery induced by forearm arterial occlusion in athletes was also higher than that of the control subjects (17.1 ± 2.3 vs 11.2 ± 1.7, p = 0.002). Furthermore, there was an association between flow-mediated dilatation and V O 2max (r = 0.69, p < 0.001). Baseline measurements of the diameter and the blood flow volume of the brachial artery were similar in both groups. During reactive hyperemia period, the percent of the changes of endothelial diameters and flow were significantly higher in athletes than in controls. Higher flowmediated dilatation levels in athletes reflect better vascular adaptation to habitual aerobic exercise.endothelium; athlete; exercise; nitric oxide

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“…In 1990, Nishimura and colleagues first validated the method of IVUS in an in vitro model and obtained an excellent correlation with histopathology (Nishimura et al 1990). Since then, this method has been used in patients as well as in animal models, and provides an accurate assessment of vascular morphology and function (Mano et al 1996, Okabe et al 2003. Though there are advantages in accuracy and validity, this method is nevertheless an invasive intervention and involves stress for the animal.…”

Section: Discussionmentioning

confidence: 99%

Transcutaneous vascular ultrasound in hypercholesterolaemic rabbits: a new method to evaluate endothelial function

Hiss¹,

Steioff²,

Loehn³

et al. 2006

Lab Anim

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SummaryMeasurement of endothelial function in patients with atherosclerosis and lipid disorders is an important tool for the risk evaluation of a cardiovascular event, such as acute myocardial infarction and stroke. The feasibility of measuring endothelial function non-invasively in animal models has been limited so far. Therefore, we compared the assessment of endothelial function by in vivo transcutaneous vascular ultrasound (TVU) with the classical method of ex vivo organ bath, using the carotid artery of hypercholesterolaemic and normocholesterolaemic rabbits. The assessments of endothelial function by both techniques were performed on the same segments of the carotid artery. Vascular ultrasound detected impaired endothelium-dependent vasorelaxation induced by acetylcholine in the common carotid artery of hypercholesterolaemic rabbits. These results strongly correlated with measurements of endothelial function of isolated carotid artery rings. Furthermore, atherogenic diet caused significant fatty streak formation in the aorta, as well as significant increase of C-reactive protein and cholesterol levels. Endothelial function, an early marker of cardiovascular risk, could be non-invasively assessed and graded by TVU measurements. It correlated highly with vasoreactivity of isolated vessels in an organ bath (r 2 ¼ 0.68). We conclude that vascular ultrasound in hypercholesterolaemic rabbits is a valid method for evaluating endothelial function associated with atherosclerosis.

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Endothelial dysfunction in the early stage of atherosclerosis precedes appearance of intimal lesions assessable with intravascular ultrasound

Cited by 113 publications

References 33 publications

Impaired Peripheral Vasoconstriction in Response to Alpha-Adrenergic Stimulation in Patients With Idiopathic Hypertrophic Cardiomyopathy

Impaired Peripheral Vasoconstriction in Response to Alpha-Adrenergic Stimulation in Patients With Idiopathic Hypertrophic Cardiomyopathy

Endothelial Flow-Mediated Dilatation and Exercise Capacity in Highly Trained Endurance Athletes

Transcutaneous vascular ultrasound in hypercholesterolaemic rabbits: a new method to evaluate endothelial function

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