Endothelial dysfunction in patients with acromegaly and It's association with Endocan

Kul, Şeref; Çaklılı, Özge Telci; Tütüncü, Yasemin; Ozcan, Fatma Betul; Aksu, Feyza; Baycan, Ömer Faruk; Atıcı, Adem; Bilgili, Ummuhan Zeynep; Takır, Mümtaz; Çalışkan, Mustafa

doi:10.1016/j.ghir.2020.101362

Cited by 2 publications

(1 citation statement)

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“…In acromegaly, the mechanisms underlying this effect could be an imbalance between endothelium derived vasodilators (particularly NO) and ROS, together with increase of blood pressure, insulin and lipid profile values[ 91 , 92 ]. Along with these risk factors, GH and insulin-like growth factor-1 (IGF-1) can directly cause changes in macrovascular structures by vasoconstriction IGF-1 mediated via the nitric oxide synthesis or damage to vascular smooth muscle cells[ 93 ].…”

Section: Endothelial Impairment In Pituitary Dysfunctionmentioning

confidence: 99%

Endothelial impairment evaluation by peripheral arterial tonometry in pediatric endocrinopathies: A narrative review

Valle¹,

Crocco²,

Chiarenza³

et al. 2021

WJD

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Endothelial dysfunction (ED) is characterized by an imbalance between vasodilator and vasoconstriction agents. Several pathological conditions clinically diagnosed in childhood and adolescence are characterized by ED and increased risk for early development of microangiopathic and macroangiopathic impairment, in particular type 1 diabetes mellitus (T1DM), T2DM, obesity, metabolic syndromeand pituitary dysfunction associated to various endocrinopathies. More recently insulin resistance following chemotherapy or radiotherapy for tumors, bone marrow transplantation for hematological malignancies ( i.e. , cancer survivors), or immunosuppressive treatment for solid organ transplantation has been observed. Assessment of ED by means of non-invasive techniques is the gold standard for early ED detection before clinical manifestation. It is aimed to recognize patients at risk and to avoid the development and progression of more serious illnesses. Reactive hyperemia-peripheral artery tonometry is a noninvasive technique to assess peripheral endothelial function by measuring modifications in digital pulse volume during reactive hyperemia, and represents a non-invasive, reproducible and operator-independent tool able to detect precocious ED. This narrative review aimed to provide an overview of the most important papers regarding ED detection by EndoPat 2000 in children and adolescents with different endocrine diseases. A comprehensive search of English language articles was performed in the MEDLINE database without using other search filters except the publication interval between 2005 and 2020.

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Section: Endothelial Impairment In Pituitary Dysfunctionmentioning

confidence: 99%