Endothelial dysfunction in COVID- 19 and cognitive impairment

Martynov, M. Yu.; Боголепова, А Н; Yasamanova, A N

doi:10.17116/jnevro202112106193

Cited by 22 publications

(4 citation statements)

References 48 publications

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“…When discussing various types of nervous system disorders caused by COVID-19, the following mechanisms are being considered: direct cytotoxic effects of SARS-CoV-2, systemic inflammatory response and cytokine storm, autoimmune injury, hypoxia resulting from respiratory and cardiovascular pathology, thrombotic and thromboembolic complications, direct endothelial involvement of the microvasculature, and the potential for direct brain injury [4,78,79].…”

Section: Nervous System Injury In Covid-19mentioning

confidence: 99%

Factors affecting the severity of COVID-19 and the development of complications

Radygina,

Mochalova

2023

Microbiology Independent Research Journal (MIR Journal)

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Due to the prevalence and diversity of both symptoms and outcomes of COVID-19, understanding the factors that determine the risk of the severe course of this disease and its possible complications is of particular importance. In this review, we present the information on the specifics of COVID-19 pathogenesis and give a theoretical justification for the factors that determine the course of this disease in patients of different age groups, patients with chronic pathology, and pregnant women. Particular attention is paid to the post-COVID syndrome.

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Section: Nervous System Injury In Covid-19mentioning

confidence: 99%

Factors affecting the severity of COVID-19 and the development of complications

Radygina,

Mochalova

2023

Microbiology Independent Research Journal (MIR Journal)

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“…КН после COVID-19 сложны и неоднородны. Известные закономерности патогенеза коронавирусной инфекции позволяют предполагать комплексный комбинированный характер поражения ЦНС с участием сразу нескольких прямых и опосредованных патологических механизмов [4,5].…”

Section: резюме _____________________________________________________...unclassified

“…Существуют и другие нейропротекторные средства, применение которых может иметь обоснование при постковидном синдроме и результативность которых в настоящее время изучается: пирацетам, глицин, холина альфосцерат, этилметилгидроксипиридина сукцинат, метилэтилпиридинола гидрохлорид и др. [4][5][6]. Группа нейротропных витаминов (В 1 , В 6 , В 12 ) может быть также рекомендована для использования в рамках курса нейрореабилитации, поскольку они участвуют во многих механизмах регуляции функционального состояния ЦНС, процессах аксонального транспорта, передачи нервных импульсов по двигательным и чувствительным волокнам, регулируют баланс ноцицептивной и антиноцицептивной систем и проч.…”

Section: резюме _____________________________________________________...unclassified

Cognitive Impairment after COVID-19

Алексеенко¹

2022

Рецепт

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Many patients after the COVID-19 infection, in addition to postinfectious asthenia, develop a complex of cognitive disorders with a predominance of impaired executive functions and short-term memory, sometimes in the form of "brain fog". Cognitive impairment occurs in a significant number of patients. They have a heterogeneous structure and a complex mechanism, usually characterized by long-term persistence. Their specific features are the lack of a clear relationship with the symptoms of asthenia, as well as a significant prevalence compared to other post-infectious disorders. All this requires the development of unified approaches to their assessment, considering the individual characteristics of patients. There is a need to continue large-scale studies to optimize the complex neurorehabilitation of patients with post-COVID-19 disorders, to evaluate the efficacy and safety of potentially effective therapeutic agents for the restoration and stimulation of cognitive functions. These pharmacological agents should control the mechanisms of systemic inflammation, hemorheological parameters and provide favorable neuroprotective effects. The individualized prognosis and prevention of the consequences of coronavirus infection remains an important problem.

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“…Hypoxia or vascular damage could explain cognitive deficits, especially in those patients with severe acute infections requiring intensive care and/or respiratory support ( Alonso-Lana et al, 2020 ). Endothelial dysfunction has also been hypothesized, causing microvascular injury ( Zhou et al, 2020 ; Martynov et al, 2021 ). However, patients with mild infections also report cognitive symptoms ( Bliddal et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

“Brain Fog” by COVID-19 or Alzheimer’s Disease? A Case Report

et al. 2021

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Cognitive symptoms after COVID-19 have been increasingly recognized several months after the acute infection and have been designated as “brain fog.” We report a patient with cognitive symptoms that started immediately after COVID-19, in which cerebrospinal fluid biomarkers were highly suggestive of Alzheimer’s disease. Our case highlights the need to examine patients with cognitive symptoms following COVID-19 comprehensively. A detailed assessment combining clinical, cognitive, and biomarker studies may help disentangle the underlying mechanisms associated with cognitive dysfunction in each case. The investigation of neurodegenerative processes in an early stage, especially in older patients, is probably warranted.

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Endothelial dysfunction in COVID- 19 and cognitive impairment

Cited by 22 publications

References 48 publications

Factors affecting the severity of COVID-19 and the development of complications

Factors affecting the severity of COVID-19 and the development of complications

Cognitive Impairment after COVID-19

“Brain Fog” by COVID-19 or Alzheimer’s Disease? A Case Report

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