Endothelial dysfunction: comparative evaluation of ultrasound dopplerography, laser dopplerflowmetry and direct monitoring of arterial pressure for conducting pharmacological tests in rats

Солдатов, Владислав О.; Malorodova, T.N.; Balamutova, Tatiana I.; Ksenofontov, Andrey O.; Dovgan, A. P.; Urozhevskaya, Zhanna S.

doi:10.3897/rrpharmacology.4.25529

Cited by 16 publications

(16 citation statements)

References 4 publications

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“…Left ventricular noncompaction (LVNC) is a form of CHD caused by arrested compaction, which usually affects both ventricles and is characterized by excessive trabeculation with deep intertrabecular recesses and a thin compact myocardium. Typical LVNC complications are systemic embolic events, ventricular arrhythmias and heart failure [38,39]. Homozygous Slc39a8null mice embryos do not survive embryogenesis and exhibit an LVNC-similar cardiac phenotype.…”

Section: Zn 2+ In Heart Developmentmentioning

confidence: 99%

Interplay between Zn2+ Homeostasis and Mitochondrial Functions in Cardiovascular Diseases and Heart Ageing

Dabravolski

Sadykhov

Kartuesov

et al. 2022

IJMS

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Zinc plays an important role in cardiomyocytes, where in exists in bound and histochemically reactive labile Zn2+ forms. Although Zn2+ concentration is under tight control through several Zn2+-transporters, its concentration and intracellular distribution may vary during normal cardiac function and pathological conditions, when the protein levels and efficacy of Zn2+ transporters can lead to zinc re-distribution among organelles in cardiomyocytes. Such dysregulation of cellular Zn2+ homeostasis leads to mitochondrial and ER stresses, and interrupts normal ER/mitochondria cross-talk and mitophagy, which subsequently, result in increased ROS production and dysregulated metabolic function. Besides cardiac structural and functional defects, insufficient Zn2+ supply was associated with heart development abnormalities, induction and progression of cardiovascular diseases, resulting in accelerated cardiac ageing. In the present review, we summarize the recently identified connections between cellular and mitochondrial Zn2+ homeostasis, ER stress and mitophagy in heart development, excitation–contraction coupling, heart failure and ischemia/reperfusion injury. Additionally, we discuss the role of Zn2+ in accelerated heart ageing and ageing-associated rise of mitochondrial ROS and cardiomyocyte dysfunction.

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Section: Zn 2+ In Heart Developmentmentioning

confidence: 99%

Interplay between Zn2+ Homeostasis and Mitochondrial Functions in Cardiovascular Diseases and Heart Ageing

Dabravolski

Sadykhov

Kartuesov

et al. 2022

IJMS

View full text Add to dashboard Cite

show abstract

“…Structural changes in diabetic myocardium are usually assessed by non-invasive reliable and reproducible techniques (such as magnetic resonance imaging and echocardiography), with myocardial fibrosis and hypertrophy as the main hallmarks of DCM [ 12 , 13 ]. While MRI has better sensitivity and capability to provide a more detailed image, it is also more expensive, thus, not so widely used as echocardiography––the main diagnostic tool for the early DCM detection [ 14 , 15 ].…”

Section: Structural and Functional Alterations In Dcmmentioning

confidence: 99%

The Role of Mitochondrial Abnormalities in Diabetic Cardiomyopathy

Dabravolski

Sadykhov

Kartuesov

et al. 2022

IJMS

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Diabetic cardiomyopathy (DCM) is defined as the presence in diabetic patients of abnormal cardiac structure and performance (such as left ventricular hypertrophy, fibrosis, and arrhythmia) in the absence of other cardiac risk factors (such as hypertension or coronary artery disease). Although the pathogenesis of DCM remains unclear currently, mitochondrial structural and functional dysfunctions are recognised as a central player in the DCM development. In this review, we focus on the role of mitochondrial dynamics, biogenesis and mitophagy, Ca2+ metabolism and bioenergetics in the DCM development and progression. Based on the crucial role of mitochondria in DCM, application of mitochondria-targeting therapies could be effective strategies to slow down the progression of the disease.

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“…Factors affecting endothelial function (for example, insulin) capable of metabolic parameters of bone tissue to cause an improvement of coronary microvascular function in individuals with chronic kidney disease remains unclear. Usually, patients with developing ASCVD also have risk factors for cardiovascular disease, including albuminuria and general growth in inflammatory markers [ 86 , 87 , 88 ]. In their study, Rein et al showed that the existence of albuminuria is linked with a higher probability of detecting significant coronary artery stenosis (≥ 50%) during angiography.…”

Section: Pathophysiologic Considerations Of Ascvd In Ckdmentioning

confidence: 99%

Atherosclerosis Specific Features in Chronic Kidney Disease (CKD)

et al. 2022

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Atherosclerosis is the major cause of cardiovascular disease, leading to a high mortality rate worldwide. Several risk factors are known to favor atherogenesis, among which are high blood pressure, smoking, diabetes mellitus, and others. Chronic kidney disease is another serious health problem associated with significant health care costs, morbidity, and mortality. Chronic kidney disease shares several risk factors with atherosclerosis and cardiovascular diseases, such as hypertension and diabetes mellitus. Additional risk factors for cardiovascular disease development should be considered in patients with chronic kidney disease. Interestingly, patients suffering from chronic kidney disease are more prone to cardiovascular problems than the general population. Moreover, chronic kidney disease is characterized by an increased atherosclerotic burden from the very early stages. The purpose of this review was to summarize data on atherosclerosis in chronic kidney disease, highlighting the specific features of the disease combination.

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Endothelial dysfunction: comparative evaluation of ultrasound dopplerography, laser dopplerflowmetry and direct monitoring of arterial pressure for conducting pharmacological tests in rats

Abstract: Introduction: The importance of the problem of endothelial dysfunction makes it essential to improve approaches to its evaluation. Due to the high diagnostic potential of ultrasound dopplerography, this method is promising in the study of endothelial function.

Cited by 16 publications

References 4 publications

Interplay between Zn2+ Homeostasis and Mitochondrial Functions in Cardiovascular Diseases and Heart Ageing

Interplay between Zn2+ Homeostasis and Mitochondrial Functions in Cardiovascular Diseases and Heart Ageing

The Role of Mitochondrial Abnormalities in Diabetic Cardiomyopathy

Atherosclerosis Specific Features in Chronic Kidney Disease (CKD)

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