Abstract:The vascular endothelium is an important regulator of vascular tone. Acute changes in mechanical stressors, such as blood flow (fluid shear) and pressure, are converted into chemical signals by the endothelium to control vasomotor function. We recently showed that endothelial Kir2.1 channels are critical to the vasodilatory response to increases in blood flow through eNOS and NO production. It is well established that obesity causes endothelial dysfunction likely through impairment of nitric oxide signaling/bi… Show more
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