Endothelial dysfunction biomarkers in sickle cell disease: is there a role for ADMA and PAI-1?

Martins, Suellen Rodrigues; Toledo, Sílvia Letícia de Oliveira; Silva, Aislander Junio da; Mendes, Fernanda; Oliveira, Marina Mendes; Ferreira, Letícia Gonçalves Resende; Dusse, Luci Maria Sant’Ana; Carvalho, Maria das Graças; Rios, Danyelle Romana Alves; Alpoim, Patrícia Nessralla; Pinheiro, Melina de Barros

doi:10.1007/s00277-021-04695-6

Cited by 4 publications

(2 citation statements)

References 56 publications

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“… 57 In sickle-cell disease, high levels of PAI-1 may cause endothelial dysfunction and exacerbate disease severity. 58 High endothelial PAI-1 may contribute to prothrombotic events in patients with COVID-19. 59 Bacterial products such as lipopolysaccharides potently induce PAI-1 by downregulating miR-30c.…”

Section: Discussionmentioning

confidence: 99%

Inducible miR-1224 silences cerebrovascular Serpine1 and restores blood flow to the stroke-affected site of the brain

Palakurti¹,

Biswas²,

Roy³

et al. 2023

Molecular Therapy - Nucleic Acids

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Section: Discussionmentioning

confidence: 99%

Inducible miR-1224 silences cerebrovascular Serpine1 and restores blood flow to the stroke-affected site of the brain

Palakurti¹,

Biswas²,

Roy³

et al. 2023

Molecular Therapy - Nucleic Acids

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“…There is clinical evidence to suggest an inverse association between serum asymmetric dimethylarginine (ADMA) levels and endothelial function in the general healthy population as well as in patients with coronary atherosclerosis or with multiple risk factors [ 12 , 13 , 14 , 15 ]. Asymmetric dimethylarginine (ADMA), a competitive inhibitor of endothelial nitric oxide synthase, is considered a likely modulation factor of endothelial dysfunction [ 16 , 17 ]. It results from the degradation of methylated arginine residues in proteins by protein methyltransferases, and it is metabolized by the enzyme NG-dimethylarginine dimethylaminohydrolase 1 and 2 (DDAH).…”

Section: Introductionmentioning

confidence: 99%

The Impact of Periodontal Inflammation on Endothelial Function Assessed by Circulating Levels of Asymmetric Dimethylarginine: A Single-Blinded Randomized Clinical Trial

Rapone

Ferrara

Qorri

et al. 2022

JCM

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Background: Endothelial dysfunction is one of the early pathogenic events of the atherosclerotic process. Severe periodontitis is considered to be an independent contributing risk factor for the pathophysiology of endothelial dysfunction. High blood concentration of asymmetric dimethylarginine (ADMA), an L-arginine analogue that inhibits nitric oxide (NO) formation, has emerged as one of the most powerful independent risk predictors of cardiovascular disease. Abrogation of periodontal inflammation might have clinical relevance, affecting the ADMA. Insufficient clinical evidence exists for drawing clear conclusions regarding the long-term effects of periodontal disease on endothelial function, and even less evidence is available specifically on ADMA concentrations and their relationship with periodontitis. The objective of this study was to evaluate the effects of intensive periodontal treatment in modulating the endothelial function via the assessment of plasma ADMA concentration in patients diagnosed severe periodontitis. Methods: This was a 6-month randomized controlled trial, including 140 patients between 41 and 63 years old who were diagnosed with severe periodontitis, free from cardiovascular disease (CVD), and had traditional cardiovascular risk factors. All patients underwent a complete medical and clinical periodontal examination, a laboratory analysis of ADMA, and an ultrasound assessment of FMD of the right brachial artery. After the screening, they were randomly assigned to receive either intensive periodontal treatment (test group, n = 70) or community-based periodontal care (control group, n = 70). A full examination was carried out at baseline, 3 and 6 months after the periodontal treatment. Results: A total of 236 individuals diagnosed with periodontitis were screened. One hundred forty participants were enrolled. No statistically significant difference was observed over the time in ADMA concentration after the intensive periodontal treatment within the test group. No differences were revealed between the groups in the ADMA concentration at baseline and during follow-up. Conclusions: Intensive periodontal treatment does not affect the plasma levels of ADMA in patients without any risk for cardiovascular disease.

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The effects of resistance training on cardiovascular factors and anti-inflammation in diabetic rats

Yoo,

Hwang,

Choi

et al. 2024

Heliyon

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Endothelial dysfunction biomarkers in sickle cell disease: is there a role for ADMA and PAI-1?

Cited by 4 publications

References 56 publications

Inducible miR-1224 silences cerebrovascular Serpine1 and restores blood flow to the stroke-affected site of the brain

Inducible miR-1224 silences cerebrovascular Serpine1 and restores blood flow to the stroke-affected site of the brain

The Impact of Periodontal Inflammation on Endothelial Function Assessed by Circulating Levels of Asymmetric Dimethylarginine: A Single-Blinded Randomized Clinical Trial

The effects of resistance training on cardiovascular factors and anti-inflammation in diabetic rats

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