Endothelial dysfunction, angiotensin-converting enzyme inhibitors and calcium antagonists

López‐Jaramillo, Patricio; Casas, Juan P.

doi:10.1038/sj.jhh.1001339

Cited by 11 publications

(5 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In MetS patients, serum adiponectin levels are decreased, while proinflammatory cytokines are elevated [18]. This imbalance in the inflammatory state leads to dysfunction of the endothelial cells, promoting the loss of their vasodilatory, antithrombotic, and antiatherogenic properties [19,20], apparently a widespread biological response in humans [21]. The relationship between inflammation and MetS is supported by several studies [1,18,22], as is the association between increased visceral fat mass and MetS [23].…”

Section: Abdominal Obesity and Adipokine Imbalancementioning

confidence: 91%

The role of leptin/adiponectin ratio in metabolic syndrome and diabetes

López‐Jaramillo¹,

Gómez-Arbeláez²,

López‐López

et al. 2013

Hormone Molecular Biology and Clinical Investigation

340

299

View full text Add to dashboard Cite

Abstract:The metabolic syndrome comprises a cluster of cardiometabolic risk factors, with insulin resistance and adiposity as its central features. Identifying individuals with metabolic syndrome is important due to its association with an increased risk of coronary heart disease and type 2 diabetes mellitus. Attention has focused on the visceral adipose tissue production of cytokines (adipokines) in metabolic syndrome and type 2 diabetes mellitus, as the levels of the anti-inflammatory adipokine adiponectin are decreased, while proinflammatory cytokines are elevated, creating a proinflammatory state associated with insulin resistance and endothelial dysfunction. In this review, we will give special attention to the role of the leptin/adiponectin ratio. We have previously demonstrated that in individuals with severe coronary artery disease, abdominal obesity was uniquely related to decreased plasma concentrations of adiponectin and increased leptin levels. Leptin/adiponectin imbalance was associated with increased waist circumference and a decreased vascular response to acetylcholine and increased vasoconstriction due to angiotensin II. Leptin and adiponectin have opposite effects on subclinical inflammation and insulin resistance. Leptin upregulates proinflammatory cytokines such as tumor necrosis factor-α and interleukin-6; these are associated with insulin resistance and type 2 diabetes mellitus. In contrast, adiponectin has anti-inflammatory properties and downregulates the expression and release of a number of proinflammatory immune mediators. Therefore, it appears that interactions between angiotensin II and leptin/adiponectin imbalance may be important mediators of the elevated risk of developing type 2 diabetes mellitus and cardiovascular diseases associated with abdominal obesity.

show abstract

Section: Abdominal Obesity and Adipokine Imbalancementioning

confidence: 91%

The role of leptin/adiponectin ratio in metabolic syndrome and diabetes

López‐Jaramillo¹,

Gómez-Arbeláez²,

López‐López

et al. 2013

Hormone Molecular Biology and Clinical Investigation

340

299

View full text Add to dashboard Cite

show abstract

“…[12][13][14] Major functional consequences of endothelial dysfunction in diabetes are reduced bioavailability of endothelium-derived nitric oxide with impaired endothelial-dependent dilatation in either type of human diabetes. 14 15 Recently, improvement in endothelial function was shown after various treatments such as lipid-lowering drugs, 16 antioxidants, 17 angiotensin-converting enzyme inhibitors, 18 calcium channel blockers 19 and oestrogen replacement. 20 Inhibitors of hydroxymethyl glutaryl coenzyme A (HMG-CoA) reductase (statins) have currently been used extensively to lower serum cholesterol levels with their proved antithrombotic, antiproliferative and anti-inflammatory properties.…”

mentioning

confidence: 99%

Effect of atorvastatin on ocular blood flow velocities in patients with diabetic retinopathy

Özkırış¹,

Erkılıç

Koç

et al. 2006

British Journal of Ophthalmology

View full text Add to dashboard Cite

Aim: To investigate blood flow velocities in the ophthalmic and central retinal arteries (CRAs) in patients with diabetic retinopathy before and after atorvastatin treatment. Methods: 45 patients with type 2 diabetes were included in this double-blind, placebo-controlled study. The patients with diabetes were divided into three subgroups: group 1 (n = 15) included patients with nonproliferative diabetic retinopathy (NPDR); group 2 (n = 15) had patients with proliferative diabetic retinopathy (PDR); and group 3 (n = 15; placebo group) included 8 patients with NPDR and 7 patients with PDR. The patients in groups 1 and 2 (atorvastatin group) received 10 mg atorvastatin daily for 10 weeks. Pre-treatment and post-treatment serum levels of total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol and triglyceride were recorded before and after treatment. Ocular blood flow velocities of the ophthalmic artery and CRA were evaluated by colour Doppler imaging before and after treatment in each group. Results: The baseline haemodynamic parameters were similar between atorvastatin and placebo groups (p.0.05 for both). Atorvastatin significantly decreased serum levels of total cholesterol, low-density lipoprotein cholesterol and triglycerides in groups 1 and 2 compared with pretreatment levels (p,0.001 for both). The mean peak systolic flow velocities (PSVs) of the ophthalmic artery in group 2, and the mean PSV and resistive indices of the CRA in groups 1 and 2 decreased significantly after atorvastatin treatment (p,0.05 for both), whereas the mean end diastolic flow velocity of the ophthalmic artery and CRA did not change (p.0.05). There was no significant difference in ocular blood flow velocities in the placebo group (p.0.05). Conclusion: Atorvastatin may have a role in reducing diabetic retinal complications, with improvement in vascular resistance and decrease in the mean PSVs of the ophthalmic artery and CRA. However, further studies with large numbers of patients are needed to obtain the long-term results of this drug.

show abstract

“…1 Furthermore, animal and human studies confirm that the beneficial effects of ACEI in reversing endothelial dysfunction. 7 On the other hand, regarding the concerning that the high level of ACE2 expression might facilitate infection with COVID-19, there is no direct evidence shown that ACE2 level is positively correlated with the infection risk. Several studies reported that COVID-19 related mortality was higher in men and the elderly than women and the young, but the level of ACE2 was shown oppositely.…”

Section: Regarding Whether Covid-19 Patients With Hypertension Shouldmentioning

confidence: 99%

Comment on “Organ‐protective effect of angiotensin‐converting enzyme 2 and its effect on the prognosis of COVID‐19”

2020

Journal of Medical Virology

View full text Add to dashboard Cite

Endothelial dysfunction, angiotensin-converting enzyme inhibitors and calcium antagonists

Cited by 11 publications

References 34 publications

The role of leptin/adiponectin ratio in metabolic syndrome and diabetes

The role of leptin/adiponectin ratio in metabolic syndrome and diabetes

Effect of atorvastatin on ocular blood flow velocities in patients with diabetic retinopathy

Comment on “Organ‐protective effect of angiotensin‐converting enzyme 2 and its effect on the prognosis of COVID‐19”

Contact Info

Product

Resources

About