Endothelial dysfunction and inflammation induced by iron oxide nanoparticle exposure: Risk factors for early atherosclerosis

Zhu, Mo; Wang, Bing; Wang, Yun; Yuan, Lamei; Wang, Hua Jian; Wang, Meng; Ouyang, Hong; Chai, Zhifang; Feng, Weiyue; Zhao, Yu

doi:10.1016/j.toxlet.2011.03.021

Cited by 195 publications

(118 citation statements)

References 36 publications

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“…During this process, nanoparticles are enclosed by early or late endosomes, within which it is, respectively, slightly acidic (pH 6.2-6.5) or pronouncedly acidic (pH 4.5-5.5). Under such an acidic microenvironment, some metallic nanoparticles, such as silver, 30 quantum dots, 31,32 and iron oxide nanoparticles, 33,34 may undergo dissolution and release metallic ions. Non-metallic nanoparticles, like mesoporous SiO 2 nanoparticles 35 may be also partially dissolved in cells or in vivo by this way.…”

Section: Absorption Distribution Metabolism and Excretion Of Nanopmentioning

confidence: 99%

Perturbation of physiological systems by nanoparticles

et al. 2014

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Nanotechnology is having a tremendous impact on our society. However, societal concerns about human safety under nanoparticle exposure may derail the broad application of this promising technology. Nanoparticles may enter the human body via various routes, including respiratory pathways, the digestive tract, skin contact, intravenous injection, and implantation. After absorption, nanoparticles are carried to distal organs by the bloodstream and the lymphatic system. During this process, they interact with biological molecules and perturb physiological systems. Although some ingested or absorbed nanoparticles are eliminated, others remain in the body for a long time. The human body is composed of multiple systems that work together to maintain physiological homeostasis. The unexpected invasion of these systems by nanoparticles disturbs normal cell signaling, impairs cell and organ functions, and may even cause pathological disorders. This review examines the comprehensive health risks of exposure to nanoparticles by discussing how nanoparticles perturb various physiological systems as revealed by animal studies. The potential toxicity of nanoparticles to each physiological system and the implications of disrupting the balance among systems are emphasized.

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Section: Absorption Distribution Metabolism and Excretion Of Nanopmentioning

confidence: 99%

Perturbation of physiological systems by nanoparticles

et al. 2014

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“…Thus, it serves as an effective cellular system for innate immune response evaluation. Recent reports mainly focused on labeling monocyte cells with NPs for therapeutic imaging (Settles, et al, 2011;Von zur Muhlen et al, 2010;Wu et al, 2006), and only a few reports demonstrated the proinflammatory effects of iron oxide NPs on human monocyte cell lines (Laskar et al, 2012;Zhu et al, 2011). Further understanding of the interactions between NPs and human monocyte cell line will be beneficial for predicting NP-induced inflammatory responses, and provide valuable information for NP design to achieve alleviated inflammation in biological systems.…”

Section: Introductionmentioning

confidence: 99%

The responses of immune cells to iron oxide nanoparticles

Sherwood

Lackey

et al. 2016

J of Applied Toxicology

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Immune cells play an important role in recognizing and removing foreign objects, such as nanoparticles. Among various parameters, surface coatings of nanoparticles are the first contact with biological system, which critically affect nanoparticle interactions. Here, surface coating effects on nanoparticle cellular uptake, toxicity and ability to trigger immune response were evaluated on a human monocyte cell line using iron oxide nanoparticles. The cells were treated with nanoparticles of three types of coatings (negatively charged polyacrylic acid, positively charged polyethylenimine and neutral polyethylene glycol). The cells were treated at various nanoparticle concentrations (5, 10, 20, 30, 50 μg ml À1 or 2, 4, 8, 12, 20 μg cm À2 ) with 6 h incubation or treated at a nanoparticle concentration of 50 μg ml À1 (20 μg cm À2 ) at different incubation times (6, 12, 24, 48 or 72 h). Cell viability over 80% was observed for all nanoparticle treatment experiments, regardless of surface coatings, nanoparticle concentrations and incubation times. The much lower cell viability for cells treated with free ligands (e.g.~10% for polyethylenimine) suggested that the surface coatings were tightly attached to the nanoparticle surfaces. The immune responses of cells to nanoparticles were evaluated by quantifying the expression of toll-like receptor 2 and tumor necrosis factor-α. The expression of tumor necrosis factor-α and toll-like receptor 2 were not significant in any case of the surface coatings, nanoparticle concentrations and incubation times. These results provide useful information to select nanoparticle surface coatings for biological and biomedical applications.

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“…They are important for reactivity (oxidation by generated reactive oxygen species), the release of hazardous substances and nanoparticle uptake by cells [1][2][3][73][74][75][76][77][78][79][80][81][82][83]. A number of surface characteristics have been identified as relevant to the inhalation hazard of nanoparticles.…”

Section: Determinants Of Human Inhalation Hazards Of Persistent Enginmentioning

confidence: 99%

“…The cardiovascular system may be negatively impacted by ingested persistent iron oxide nanoparticles [80]. In the case of amorphous SiO 2 nanoparticles, ingestion of large amounts has been associated with negative impacts on liver functioning in mice [116].…”

Section: Health Hazards Linked To Ingestion Of Persistent Inorganic Amentioning

confidence: 99%

Human health hazards of persistent inorganic and carbon nanoparticles

Reijnders

2012

J Mater Sci

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Persistent inorganic and carbon nanoparticles are increasingly engineered for applications and may also be present in conventional materials such as carbon black. Furthermore, they may originate from conventional non particulate materials by processes such as wear and tear. Persistent inorganic and carbon nanoparticles can be hazardous to humans. Relatively much research regards the hazards of inhaled nanoparticles. These may give rise to respiratory disease and to negative effects on other organs, including the cardiovascular system. Determinants of risk of inhaled nanoparticles include: number, size, surface characteristics, shape, structure, and the formation of assemblages. These determinants should preferentially be considered in exposure metrics. A major molecular mechanism underlying the inhalation hazard of nanoparticles is the generation of reactive oxygen species, but other mechanisms such as interactions with proteins and DNA may also contribute. Health hazards may also be linked to ingestion of persistent inorganic and carbon nanoparticles, dermal exposure and exposure of the eye. Standards for workplace exposure to persistent inorganic and carbon are currently emerging and there are options for hazard reduction by elimination and substitution of hazardous nanoparticles and by engineering controls.

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Endothelial dysfunction and inflammation induced by iron oxide nanoparticle exposure: Risk factors for early atherosclerosis

Cited by 195 publications

References 36 publications

Perturbation of physiological systems by nanoparticles

Perturbation of physiological systems by nanoparticles

The responses of immune cells to iron oxide nanoparticles

Human health hazards of persistent inorganic and carbon nanoparticles

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