Endothelial Dysfunction and C-Reactive Protein in Relation with the Severity of Obstructive Sleep Apnea Syndrome

Abstract

As a marker of nocturnal hypoxemia, ODI rather than AHI might better explain the relationship between OSAS and FMD. Because body mass index and waist-to-hip ratio were identified as risk factors of high serum CRP in OSAS, obesity should be considered when predicting cardiovascular complications in OSAS.

Patients With Obstructive Sleep Apnea Exhibit Impaired Endothelial Function After Myocardial Infarction

“…This fi nding is consistent with the fi nding of a prior study. 23 The causal association between minSa o 2 and FMD is biologically plausible since endotheliumdependent vasodilation is mediated by nitric oxide, and its biosynthesis is an oxygen-dependent process. In fact, previous studies suggest that chronic sleeprelated intermittent hypoxia might have effects on vascular nitric oxide synthesis or availability.…”

Impact of hyperventilation and apnea on myocardial oxygenation in patients with obstructive sleep apnea – An oxygenation-sensitive CMR study

“…This could be linked to higher oxidative stress [25][26][27], endothelial dysfunction [28][29][30], less nitric oxide production [31], and inflammation [32]. All of these pathophysiological aspects could contribute to a decreased myocardial adaptive response.…”

What can anthropometric measurements tell us about obstructive sleep apnoea?

“…However, some studies have demonstrated that the relation between BMI and OSA is unclear. BMI is the traditional marker for obesity, but there has been disagreement about whether it is risk factor for OSA [6,14,17,20]. BMI was increased especially in females with OSA, but it was not correlated with AHI in polysomnography [17].…”