Endothelial dysfunction and arterial wall stiffness: New targets in diabetic nephropathy

Муркамилов, И Т; Сабиров, И С; Fоmin, Victоr; Yusupov, F. A.

doi:10.17116/terarkh2017891087-94

Cited by 5 publications

(3 citation statements)

References 15 publications

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“…Як було показано в роботах низки дослідників, артеріальна жорсткість є незалежним фактором кардіоваскулярного ризику, кількоразово підвищуючи ризик кардіоваскулярних катастроф (інсульту, розшаровуючої аневризми аорти та ін.) [6].…”

Section: вступunclassified

Interrelation Between the Changes in Quality of Life and Arterial Stiffness in Patients With Diabetes Mellitus Type 2 and Concomitant Obesity

Fushtey¹,

Solovyuk²,

Solovyuk³

2018

Act. Probl. of the Modern Med.

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The purpose of this work was to study the general characteristics of quality of life (QoL), the effect of overweight on QoL, the nature of eating behaviour in patients with diabetes mellitus (DM) type 2 and concomitant overweight (OW) and obesity, as well as to establish the correlation with indicators of functional state of the arterial vessels. 64 people (34 women and 30 men) with DM and concomitant overweight and obesity (average age 56.3 ± 10.23 years) formed the 1 group, 34 people (19 women and 15 men), whose average age was 55.6 ± 11.92 years constituted the 2 group, and 28 healthy individuals formed the control group. SF-36v2 questionnaires were used to evaluate QoL. The effect of overweight on QoL was analyzed according to the IWQOL-Lite questionnaire data, the patterns of eating behaviour were determined by the COEQ4 for 7 days using FPRS questionnaire. The functional state of the arterial vessels was assessed by estimating the pulse wave velocity using the automated rheographic complex ReoCom (KhAI Medika (Ukraine)). The patients with DM and concomitant overweight and obesity were found to experience some changes in QoL according to the SF-36v2 questionnaire. The changes were primarily characterized by a decrease in physical activity, as well as in social and emotional status. These changes differed not only from the QoL assessment by healthy individuals, but also from those of patients with DM and normal body weight. The nature of eating behaviour in overweight or obese patients with DM was characterized by an increased hunger in parallel with a worsened emotional state and an increased desire to eat certain types of foods that can contribute to weight gain. Structural changes in arterial vessels that typically are indicative of arterial stiffness correlate with indicators of emotional state and physical activity in patients with DM and comorbid overweight and obesity.

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Section: вступunclassified

Interrelation Between the Changes in Quality of Life and Arterial Stiffness in Patients With Diabetes Mellitus Type 2 and Concomitant Obesity

Fushtey¹,

Solovyuk²,

Solovyuk³

2018

Act. Probl. of the Modern Med.

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“…This condition results in vasoconstriction and endothelial oxidative stress that causes significant cell death and worsening of the condition of the patient with DN. 9,10 The modulation of the oxidative stress process is performed by the p66Shc protein, which is an isoform of the SHC1 gene, located in the first chromosome. p66Shc acts on the endothelial cell by increasing the production of ROS through three different mechanisms, in the cell nucleus, in the cell membrane, and in the mitochondria, In the nucleus, p66Shc is mediated by Forkhead Box Sub-Group O (FOXO), resulting in decreased expression of the enzymes ROS-scavenging catalase (CAT) and manganese superoxide dismutase (MnSOD), both responsible for regulating ROS levels during cellular oxidative stress.…”

Section: Introductionmentioning

confidence: 99%

A Cross-Sectional Study of p66Shc Gene Expression in Liquid Biopsy of Diabetic Patients. Is it Possible to Predict the Onset of Renal Disease?

Simões

Perez²,

Alves³

et al. 2023

Int J Med Stud

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Background: Diabetic nephropathy (DN) is a disorder affecting glomerular function that, histologically, is due to the presence of glomerulosclerosis accompanied with endothelial dysfunction of the afferent and efferent renal arterioles. Insulin resistance in diabetic patients is known to be one of the causes of endothelial dysfunction because it increases oxidative stress, and one of the main genes regulating the production pathways of reactive oxygen species is p66Shc. The aim of this study was to evaluate the p66Shc gene expression as a precocious biomarker of renal dysfunction in diabetic patients, using liquids samples of urine sediment and peripheral blood. Methods: 29 diabetic patients and 37 healthy donors were recruited from the Centro Universitário FMABC outpatient clinic. The RT-gPCR technique was applied to evaluate p66Shc gene expression in urine and peripheral blood samples from diabetic patients, which were compared with healthy donors. Results: There was no significant expression of p66Shc gene in samples from diabetic patients compared with healthy donors. However, p66Shc expression in the blood samples of diabetics (0.02417±0.078652-ΔCT, n=29) was 3.6 times higher than in healthy participants (0.00689±0.01758, n=37) while in the urine samples, it was 1.48 times higher in diabetics group (0.02761±0.05412-ΔCT) than in CTL group (0.0186±0.02199). Conclusion: There was no significant p66Shc gene expression in peripheral blood and urine samples of diabetic patients without kidney injury compared with healthy donors, although there is a tendency for this gene to participate in the oxidative imbalance present in diabetes.

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“…Furthermore, it has been shown that functional impairment of the arterial wall can be detected well before symptoms of CVD are present [ 2 , 3 ]. There are several studies that have also shown a potential link between endothelial dysfunction and arterial stiffness specifically in hypertensive individuals, which suggest that they may be used as a critical tool to evaluate the progression of CVD [ 4 , 5 ]. The occurrence of arterial stiffness, hypertension, and related cardiovascular diseases is higher in aged populations as compared to younger counterparts [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

Vascular hemodynamics and blood pressure differences between young and older women

2021

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Background Cardiovascular disease is one of the main causes of death in the United States, and hypertension is a primary risk factor. Therefore, the primary causes of hypertension need to be identified so they may be addressed for treatment. The purpose of this study was to compare blood pressure with hemodynamic values and identify factors that may explain blood pressure differences between a cohort of healthy normotensive younger and older women. Methods Participants were 49 young (age: 33.8 ± 5.9) and 103 old (age: 65.8 ± 4) who were non-hypertensive, had no previous history of heart disease or type 2 diabetes, body mass index less than 30 kg/m2, normal electrocardiography response at rest and during exercise, nonsmokers, and no use of medications known to affect cardiovascular or metabolic function. Body composition measured by dual-energy X-ray absorptiometry. Hemodynamic values measured by non-invasive pulse wave velocity through radial artery tonometry. Markers of inflammation measured through blood sample analysis. Results Significant differences exist between young and old groups in %fat (P < 0.001), systolic blood pressure (SBP) (P = 0.001), large artery elasticity (P = 0.005), small artery elasticity (P < 0.001), systemic vascular resistance (P = 0.004), total vascular impedance (P < 0.001), estimated cardiac output (P < 0.001), and tumor necrosis factor-⍺ (TNF-⍺) (P < 0.001). Using ANCOVA the difference in SBP between age groups was no longer significant after adjusting for small artery elasticity (P < 0.001) and TNF-⍺ (P = 0.041). Conclusions These data demonstrate that blood pressure and vascular hemodynamic measures differ significantly between young and old women independent of body composition. Furthermore, these differences may be explained by the inflammation marker TNF-⍺ and/or small artery elasticity.

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Endothelial dysfunction and arterial wall stiffness: New targets in diabetic nephropathy

Cited by 5 publications

References 15 publications

Interrelation Between the Changes in Quality of Life and Arterial Stiffness in Patients With Diabetes Mellitus Type 2 and Concomitant Obesity

Interrelation Between the Changes in Quality of Life and Arterial Stiffness in Patients With Diabetes Mellitus Type 2 and Concomitant Obesity

A Cross-Sectional Study of p66Shc Gene Expression in Liquid Biopsy of Diabetic Patients. Is it Possible to Predict the Onset of Renal Disease?

Vascular hemodynamics and blood pressure differences between young and older women

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