Endothelial damage and angiogenesis in hypertensive patients: relationship to cardiovascular risk factors and risk factor management

Felmeden, Dirk C.

doi:10.1016/s0895-7061(02)03149-7

Cited by 134 publications

(98 citation statements)

References 22 publications

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“…It has previously been shown that plasma VEGF was higher in hypertensive patients compared with controls (25,26) and that the VEGF levels correlated significantly with age, systolic and diastolic blood pressure, 10-year cardiovascular disease (CVD) risk, and CVD risk scores. Indices of endothelial damage and angiogenesis are beneficially changed by intensive cardiovascular risk factor management (26).…”

Section: Discussionmentioning

confidence: 99%

Circulating vascular endothelial growth factor and active renin concentrations and prostaglandin E2 urinary excretion in patients with adrenal tumours

Zacharieva

Atanassova

Orbetzova

et al. 2004

European Journal of Endocrinology

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Section: Discussionmentioning

confidence: 99%

Circulating vascular endothelial growth factor and active renin concentrations and prostaglandin E2 urinary excretion in patients with adrenal tumours

Zacharieva

Atanassova

Orbetzova

et al. 2004

European Journal of Endocrinology

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“…1,2 Endothelial dysfunction is common in patients with different cardiovascular risk factors, that is, diabetes mellitus, 3 hypercholesterolaemia, 4 hyperhomocysteinaemia 5 and hypertension. 6 Several factors have been proposed to explain endothelial dysfunction such as reduction of the activity and/ or expression of the endothelial nitric oxide synthase (eNOS) and/or increased vascular formation of oxygen-derived free radicals. 7 There is growing evidence that increased levels of the endogenous NO synthase inhibitor asymmetric dimethylarginine (ADMA) may contribute to endothelial dysfunction.…”

Section: Introductionmentioning

confidence: 99%

Increased circulating concentrations of asymmetric dimethylarginine (ADMA) in white coat hypertension

et al. 2005

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Elevated plasma levels of the endogenous nitric oxide (NO) synthase inhibitor asymmetric dimethylarginine (ADMA) contribute to endothelial dysfunction and seem to be a predictor for cardiovascular mortality. Elevated ADMA plasma concentrations have been demonstrated in patients with hypertension. However, the plasma concentrations of ADMA in white coat hypertension (WCH) has not been previously studied. The aim of this study was to evaluate ADMA in WCH and compare with normotensive (NT) and hypertensive (HT) patients. We also evaluated the relation between ADMA and NO in these three groups. For this purpose, 34 NT, 34 white coat hypertensive (clinical hypertension and ambulatory daytime blood pressure o135/85 mmHg) and 34 HT patients were recruited in this study. The subjects were matched for age, gender, body mass index (BMI) and the patients with smoking habit, dyslipidaemia and diabetes mellitus were excluded. The ADMA levels were determined by high performance liquid chromatography. Plasma ADMA levels were significantly higher in WCH group than in the NT group (3.2170.49 lmol/l vs 2.8470.58 lmol/l, P ¼ 0.046). It was significantly higher in the HT group than in the NTs (4.2470.38 lmol/l, Po0.001). There was also a significant difference between the HT and WCH groups (Po0.001). The WCH subjects had significantly higher levels of NO than the HTs (41.6872.23 vs 32.1872.68 lmol/l; Po0.001) and significantly lower values than the NTs (48.247 4.29 lmol/l; Po0.001). In WCH and HT group, there was a negative correlation between ADMA and NO (r ¼ À0.515, P ¼ 0.003 and r ¼ À0.389, P ¼ 0.034, respectively). In NT subjects, there was no correlation between these two parameters (r ¼ À0.287, P ¼ 0.124). The correlation between ADMA and NO was stronger in WCH group than in HT group. Although NO levels in HT patients were lower than WCHs and ADMA levels were higher in HT patients than WCHs, the negative correlation of these two parameters were more pronounced in WCH group. Decreased NO and increased ADMA levels in WCH may indicate endothelial dysfunction. Our data indicate also that WCH represent an intermediate group between NT and HT when endothelial dysfunction is concerned.

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“…5 Moreover, abnormal indices of angiogenesis in hypertension are correlated with target organ damage 6 and cardiovascular outcome. 4,7,8 The elevated Ang levels in hypertension suggest the possibility of alterations in the whole vessel remodelling process. 24 Given that angiogenesis plays a pivotal role in cardiovascular remodelling that may alter the mechanical wall properties, we sought a correlation between arterial stiffening, as expressed by pwv, and Ang-1 and Ang-2 gene expression in peripheral monocytes in patients with essential hypertension.…”

Section: Discussionmentioning

confidence: 99%

“…4 In particular, hypertensive patients exhibit higher levels of plasma angiopoietin-1 (Ang-1) and Ang-2, 5 which are correlated with target organ damage 6 and cardiovascular outcome. 4,7,8 Although Angs may exert a potent mitogenic effect and promote arterial remodelling, 9 the underlying pathophysiological mechanisms potentially linking angiogenesis with adverse outcome in hypertension are largely unclear.…”

Section: Introductionmentioning

confidence: 99%

Arterial stiffness in hypertensives in relation to expression of angiopoietin-1 and 2 genes in peripheral monocytes

et al. 2010

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Angiopoietins (Angs) are important angiogenic and endothelial cell growth factors with many functions, including influence on the vascular wall. Pulse-wave velocity (pwv) is an independent marker of cardiovascular adverse outcome in hypertensives, although all the pathophysiological mechanisms that affect it have not yet been determined. We investigated the relationship between arterial stiffness and Ang-1 and Ang-2 gene expression in the peripheral blood monocytes of hypertensive patients. We studied 53 patients who had untreated grade-1 or grade-2 essential hypertension and no indications of other organic heart disease. Carotid-femoral (c-f) and carotid-radial (c-r) artery waveforms were measured and pwv was determined. The monocytes were isolated using anti-CD14 þ antibodies and mRNAs were estimated by real-time quantitative reverse transcription-PCR. Ang-1 gene expression was strongly correlated with both c-f-pwv (r ¼ 0.952, Po0.001) and c-r-pwv (r ¼ 0.898, Po0.001). Similarly, Ang-2 gene expression was significantly correlated with both c-f-pwv (r ¼ 0.471, P ¼ 0.002) and c-r-pwv (r ¼ 0.437, P ¼ 0.003). Our data provide important evidence that Ang-1 and Ang-2 gene expression levels in peripheral monocytes are closely related with pwv in patients with essential hypertension. This positive correlation may suggest a link between angiogenesis and arterial stiffness in those patients.

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Endothelial damage and angiogenesis in hypertensive patients: relationship to cardiovascular risk factors and risk factor management

Abstract: In hypertension, the processes of endothelial damage and angiogenesis are abnormal, and correlate with overall cardiovascular risk. Indices of endothelial damage and angiogenesis are beneficially changed by intensive cardiovascular risk factor management.

Cited by 134 publications

References 22 publications

Circulating vascular endothelial growth factor and active renin concentrations and prostaglandin E2 urinary excretion in patients with adrenal tumours

Circulating vascular endothelial growth factor and active renin concentrations and prostaglandin E2 urinary excretion in patients with adrenal tumours

Increased circulating concentrations of asymmetric dimethylarginine (ADMA) in white coat hypertension

Arterial stiffness in hypertensives in relation to expression of angiopoietin-1 and 2 genes in peripheral monocytes

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