Endothelial Control of Arterial Distensibility

Abstract

Medical Research Society 9P m: To evaluate the efficacy of an open access carotid duplex service in relation to the pattern of referral and outcome in a local population. Method: Review of patients attending Open Access Carotid Duplex Service in 1996197. &&&:There were 789 patients scanned (403 male, 386 female) with a mean age of 65 years and a mean waiting time of 10.9 days. The largest proportion of referrals was from physicians(39.9%) followed by vascular surgeons(22.3%), other feeder hospitals(2l.9%), general practitioners(6.6%) and others(9.3%). Of the patients referred for scanning, 623(78.90/0) had "hard symptoms" (hemimotorl hemisensory loss, dysphasia or amaurosis fugax) and of this group only 157(25.2%) had significant stenoses. The significant stenosis(>70 %) pick up rate for all groups was 25.6% (202 patients). Of the 89 patients referred by vascular surgeons, 49 (55%) underwent subsequent carotid endarterectomy. I 13 patients from other sources who had significant stenoses did not have any known vascular follow up. 46 asymptomatic high risk patients also had Transcranial doppler monitoring out of which 7 patients (15.2%) had evidence of ongoing embolisation. Conclusion: Open Access Carotid Duplex is an effective method of identifying a population at risk. This study has also identified a large subgroup that would not have seen a vascular specialist and may thus provide a safety net for such patients.

The role of endothelial dysfunction in the pathophysiology of erectile dysfunction in diabetes and in determining response to treatment

“…Pulse‐wave velocity may be used to assess arterial distensibility as it is inversely proportional to the square root of distensibility [10]. Non‐invasively acquired measures of pulse‐wave velocity during reactive hyperaemia represent an alternative measure of endothelium‐dependent responses [11].…”

Role of nitric oxide and oxidative stress in baroreceptor dysfunction in patients with chronic heart failure

“…In order to assess whether changes in BRS were associated with changes in arterial distensibility, brachioradial PWV was assessed in the arm using an automated non-invasive commercially available peripheral pulse waveform recorder (QVLP84; SciMed, Bristol, U.K.) [18]. PWV was calculated as distance between cuffs divided by transit time.…”