Endothelial cells produce angiocrine factors to regulate bone and cartilage via versatile mechanisms

Zhu, Sipin; Bennett, Samuel; Kuek, Vincent; Chen, Xiang; Xu, Huazi; Rosen, Vicki; Xu, Jiake

doi:10.7150/thno.45422

Cited by 64 publications

(57 citation statements)

References 100 publications

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“…[46][47][48] Evidence has shown that the crosstalk between osteoblast or osteoclast lineage cells and type H ECs promotes subchondral angiogenesis and aggravates subchondral bone remodelling. [49][50][51] Type H ECs surrounded by osterix-expressing osteoprogenitors produce high levels of angiocrine factors (such as plateletderived growth factor (PDGF)-A, TGF-β1 and fibroblast growth factor (FGF)−1), stimulating survival, proliferation and differentiation of these osteoprogenitors to promote local bone formation. 52 53 Type H ECs intercommunicate via the intercellular Notch/delta-like protein 4 (DLL4) signalling pathway to induce the production of Noggin, 54 which stimulates the differentiation of osteoprogenitors surrounding vessels.…”

Section: Microstructural and Histopathological Alterations In Oa Subcmentioning

confidence: 99%

Microenvironment in subchondral bone: predominant regulator for the treatment of osteoarthritis

et al. 2020

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Osteoarthritis (OA) is a degenerative joint disease in the elderly. Although OA has been considered as primarily a disease of the articular cartilage, the participation of subchondral bone in the pathogenesis of OA has attracted increasing attention. This review summarises the microstructural and histopathological changes in subchondral bone during OA progression that are due, at the cellular level, to changes in the interactions among osteocytes, osteoblasts, osteoclasts (OCs), endothelial cells and sensory neurons. Therefore, we focus on how pathological cellular interactions in the subchondral bone microenvironment promote subchondral bone destruction at different stages of OA progression. In addition, the limited amount of research on the communication between OCs in subchondral bone and chondrocytes (CCs) in articular cartilage during OA progression is reviewed. We propose the concept of ‘OC–CC crosstalk’ and describe the various pathways by which the two cell types might interact. Based on the ‘OC–CC crosstalk’, we elaborate potential therapeutic strategies for the treatment of OA, including restoring abnormal subchondral bone remodelling and blocking the bridge—subchondral type H vessels. Finally, the review summarises the current understanding of how the subchondral bone microenvironment is related to OA pain and describes potential interventions to reduce OA pain by targeting the subchondral bone microenvironment.

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Section: Microstructural and Histopathological Alterations In Oa Subcmentioning

confidence: 99%

Microenvironment in subchondral bone: predominant regulator for the treatment of osteoarthritis

et al. 2020

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“… 126 , 193 Within the complex niche, ECs mediate HSC self-renewal, mobilization, and homing, with the expression of critical angiocrine factors, including stem cell factor (SCF), C-X-C motif chemokine 12 (CXCL12), and interleukins (ILs). 193 , 194 EC-specific deletion of SCF or CXCL12 leads to depletion of HSCs and repaired long-term repopulation activity. 43 In addition, elevated activation of Notch signaling in ECs not only leads to increased blood flow to the bone but also expands the HSC pool by improving vascular niche function, suggesting that ECs and Notch signaling are critical regulators of HSC activity and cellular polarity.…”

Section: Bone and Blood Vessels In The Hematopoiesis Microenvironmentmentioning

confidence: 99%

Skeleton-vasculature chain reaction: a novel insight into the mystery of homeostasis

Chen

Huang

et al. 2021

Bone Res

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Angiogenesis and osteogenesis are coupled. However, the cellular and molecular regulation of these processes remains to be further investigated. Both tissues have recently been recognized as endocrine organs, which has stimulated research interest in the screening and functional identification of novel paracrine factors from both tissues. This review aims to elaborate on the novelty and significance of endocrine regulatory loops between bone and the vasculature. In addition, research progress related to the bone vasculature, vessel-related skeletal diseases, pathological conditions, and angiogenesis-targeted therapeutic strategies are also summarized. With respect to future perspectives, new techniques such as single-cell sequencing, which can be used to show the cellular diversity and plasticity of both tissues, are facilitating progress in this field. Moreover, extracellular vesicle-mediated nuclear acid communication deserves further investigation. In conclusion, a deeper understanding of the cellular and molecular regulation of angiogenesis and osteogenesis coupling may offer an opportunity to identify new therapeutic targets.

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“…In addition to the conventional functions, increasing evidence has indicated that they perform other physiological functions, such as gatekeeping of immune responses (Shetty et al 2018) and active contribution to the growth or maintenance of the homeostasis in tissue repair or regeneration in the surrounding tissue (Rafii et al 2016). In the development, tissue-derived signals induce angiogenesis, and ECs release growth factors or directly control or contribute to organ morphogenesis (Ramasamy et al 2015;Zhu et al 2020). Moreover, tissue repair and regeneration depend on local ECs.…”

Section: Introductionmentioning

confidence: 99%

Pathological angiogenesis and inflammation in tissues

2020

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The role of angiogenesis in the growth of organs and tumors is widely recognized. Vascular–organ interaction is a key mechanism and a concept that enables an understanding of all biological phenomena and normal physiology that is essential for human survival under pathological conditions. Recently, vascular endothelial cells have been classified as a type of innate immune cells that are dependent on the pathological situations. Moreover, inflammatory cytokines and signaling regulators activated upon exposure to infection or various stresses play crucial roles in the pathological function of parenchymal cells, peripheral immune cells, stromal cells, and cancer cells in tissues. Therefore, vascular–organ interactions as a vascular microenvironment or tissue microenvironment under physiological and pathological conditions are gaining popularity as an interesting research topic. Here, we review vascular contribution as a major factor in microenvironment homeostasis in the pathogenesis of normal as well as cancerous tissues. Furthermore, we suggest that the normalization strategy of pathological angiogenesis could be a promising therapeutic target for various diseases, including cancer.

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Endothelial cells produce angiocrine factors to regulate bone and cartilage via versatile mechanisms

Cited by 64 publications

References 100 publications

Microenvironment in subchondral bone: predominant regulator for the treatment of osteoarthritis

Microenvironment in subchondral bone: predominant regulator for the treatment of osteoarthritis

Skeleton-vasculature chain reaction: a novel insight into the mystery of homeostasis

Pathological angiogenesis and inflammation in tissues

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