Endothelial cells and angiogenesis

Sepp, Norbert; Fritsch, P.; Luger, Thomas A.

doi:10.1111/j.1600-0625.1997.tb00172.x

Cited by 9 publications

(5 citation statements)

References 13 publications

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“…[24][25][26] Proliferation and migration of ECs has been shown to be an essential criterion for angiogenesis. [27][28][29] We demonstrate active EC proliferation that turns the ischemic hemisphere into a highly plastic vascular system with multiple angiogenic sprouts. The continued angiogenic sprouting results in an increased vessel density in both perilesion and lesion region.…”

Section: Discussionmentioning

confidence: 87%

EphrinB2 Activation Enhances Vascular Repair Mechanisms and Reduces Brain Swelling After Mild Cerebral Ischemia

Ghori

Freimann

Nieminen-Kelhä

et al. 2017

ATVB

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Objective— Cerebral edema caused by the disruption of the blood–brain barrier is a major complication after stroke. Therefore, strategies to accelerate and enhance neurovascular recovery after stroke are of prime interest. Our main aim was to study the role of ephrinB2/EphB4 signaling in mediating the vascular repair and in blood–brain barrier restoration after mild cerebral ischemia occlusion/reperfusion. Approach and Results— Here, we show that the guidance molecule ephrinB2 plays a key role in neurovascular protection and blood–brain barrier restoration after stroke. In a focal stroke model, we characterize the stroke-induced damage to cerebral blood vessels and their subsequent endogenous repair on a cellular, molecular, and functional level. EphrinB2 and its tyrosine kinase receptor EphB4 are upregulated early after stroke by endothelial cells and perivascular support cells, in parallel to their reassembly during neurovascular recovery. Using both retroviral and pharmacological approaches, we show that the inhibition of ephrinB2/EphB4 signaling suppresses post-middle cerebral artery occlusion neurovascular repair mechanisms resulting in an aggravation of brain swelling. In contrast, the activation of ephrinB2 after brain ischemia leads to an increased pericyte recruitment and increased endothelial–pericyte interaction, resulting in an accelerated neurovascular repair after ischemia. Conclusions— We show that reducing swelling could result in improved outcome because of reduction in damaged brain tissue. We also identify a novel role for ephrinB2/EphB4 signaling in the maintenance of the neurovascular homeostasis and provide a novel therapeutic approach in reducing brain swelling after stroke.

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Section: Discussionmentioning

confidence: 87%

EphrinB2 Activation Enhances Vascular Repair Mechanisms and Reduces Brain Swelling After Mild Cerebral Ischemia

Ghori

Freimann

Nieminen-Kelhä

et al. 2017

ATVB

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“…PDGF and TGF-b are usually secreted in damaged tissues and stimulate proliferation of fibroblasts and smooth muscle cells resulting with enhanced synthesis of collagen and extracellular matrix which are necessary for wound healing [17]. Vessels formation is an important part of this process and both PDGF and TGF-b demonstrate chemotactic activity causing migration of pro-angiogenic inflammatory cells [18,19]. Psoriasis activity is an effect of imbalance between stimulation and inhibition of keratinocyte proliferation.…”

Section: Discussionmentioning

confidence: 99%

Effect of psoriasis activity on VEGF and its soluble receptors concentrations in serum and plaque scales

et al. 2010

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“…Tumor-specific targeting has been performed by using a drug conjugated to a tumor-specific molecule such as an adriamycin-conjugated poly (ethylene glycol) linker with enzymatically cleavable peptide sequences and monoclonal antibodies binding to specific tumor antigens such as rituximab, trastuzumab, gemtuzumabozogamicin, alemtuzumab, ibritumomab tiuxetan, and gefitinib (Abou-Jawde et al, 2003;Kohler & Milstein, 1975;Suzawa et al, 2002). Targeting through angiogenesis, a process vital to the continued development of a tumor mass has been performed by using the most prominent angiogenesis stimulatory molecules such as vascular endothelial growth factor, basic fibroblast growth factor, platelet-derived growth factor, transforming growth factors, and certain matrix metalloproteinases and some endogenous angiogenesis inhibitors such as the interferon family, angiopioetin, interleukin, thrombospondin-1 and -2, tissue inhibitor, angiostatin, and endostatin (Fox et al, 1993;Hobson & Denekamp, 1984;Ingber, 1990;Sepp et al, 1997).…”

Section: The Use Of Nanoparticles In Drug Deliverymentioning

confidence: 99%

Nanoparticle-Based Medical Therapy and Research

Choi¹,

Choi²

2013

Audiol Speech Res

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Recently, a variety of nanoparticles have been considered as an attractive way that is effective and helpful in diagnosis and treatment of cancer and diseases through development in nanoscience and nanotechnology. Nanoparticles refer to tiny particles between 100 nm and 1 µm. The objective of this paper is to review the current applications, the research trend, and the possibility in future of the metallic nanoparticles in drug delivery, imaging, therapy, and combined imaging and therapy, as well as hearing research. The nanoparticles for effective drug delivery have been used to selectively target and kill the cancer cells or tumor cells and to transport molecules, nanoparticles, and cells into solid tumors in chemotherapy and radiation. The nanoparticles in hearing research have been used to prevent or treat the noise-, ototoxicity-, inflammatory-, viral-, and immune-mediated hearing loss and cell death processes using genetic and trophic factors enhancing repair processes of hair cell in the cochlea. The nanoparticles for effective imaging have been used to confirm a detailed view of targeting in live cells and their interactions with intracellular molecules and as contrast agents for CT, MRI, and x-ray imaging. The nanoparticles in therapy have been used in chemotherapy, immunotherapy, radiotherapy, thermotherapy, and photodynamic therapy by targeting the fast growing cells, blocking some critical elements of the cell division process, transporting various compositions, and increasing the dose and effectiveness of x-rays. Recently, the nanoparticles have been used to increase the effectiveness of individual modality image or therapy by combining noninvasive multimodality imaging and molecular therapy. This method can provide a new insight and intuition on the diagnosis and treatment of the various cancers and diseases including hearing loss.

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Endothelial cells and angiogenesis

Cited by 9 publications

References 13 publications

EphrinB2 Activation Enhances Vascular Repair Mechanisms and Reduces Brain Swelling After Mild Cerebral Ischemia

EphrinB2 Activation Enhances Vascular Repair Mechanisms and Reduces Brain Swelling After Mild Cerebral Ischemia

Effect of psoriasis activity on VEGF and its soluble receptors concentrations in serum and plaque scales

Nanoparticle-Based Medical Therapy and Research

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