Endothelial Cells Adhesion on Modified Polyurethane Surface as the Way to Fabricate a Novel Material for Cardiosurgery

Ziętek, Paulina Anna; Butruk, B.; Ciach, Tomasz

doi:10.1039/9781849737135-00149

Cited by 1 publication

(1 citation statement)

References 45 publications

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“…Therefore the drug-eluting stents show promise with marked reduction in intimal hyperplasia compared to bare, metal stents. The above theme was the subject of investigations (Hirata et al, 2013;Kleinedler, 2012;Ziętek et al, 2013).…”

Section: Sequential Unit System Su4mentioning

confidence: 99%

Determination of diffusion coefficient and permeability through the barrier of substance in simulated biomedical systems

Adach

Kister

Skassa

et al. 2017

Chemical and Process Engineering

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The investigations deal with mass transfer in simulated biomedical systems. The modification of classical diffusion chamber, sequential unit (SU) system, imitated different biomedical setups, boundary conditions. The experiments simulated: diffusion chamber (also with two barriers), transport through the membrane to the blood stream, transport from the stent eluting drug simultaneously to the vessel cells and to the blood stream. The concentrations of substances and the relative mass increases/decreases for SU systems indicate that the order of the curves follows the order of mass transfer resistances. The strong dependence of mass transfer rates versus type of diffusing substance was confirmed. The calculated drug fluxes, diffusion coefficients, permeation coefficients are convergent with literature. Permeation coefficients for complex sequential systems can be estimated as parallel connexion of constituent coefficients. Experiments approved functionality of the SU for investigations in a simulated biomedical system. Obtained data were used for numerical verification.

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Section: Sequential Unit System Su4mentioning

confidence: 99%