Abstract:Background and purpose: Pregnancy-associated vascular remodeling is
essential for both maternal and fetal health. We have previously shown
that maternal endothelial cell tetrahydrobiopterin (BH4) deficiency
causes poor pregnancy outcomes. Here, we investigated the role and
mechanisms of endothelial cell-mediated vasorelaxation function in these
outcomes. Experimental approach: The vascular reactivity of mouse aortas
and uterine arteries from non-pregnant and pregnant endothelial
cell-specific BH4 deficient mic… Show more
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