Endothelial Cell Plasma Membrane Biomechanics Mediates Effects of Pro-Inflammatory Factors on Endothelial Mechanosensors: Vicious Circle Formation in Atherogenic Inflammation

Barvitenko, Nadezhda; Ashrafuzzaman, Md.; Lawen, Alfons; Skverchinskaya, Elisaveta; Saldanha, Carlota; Manca, Alessia; Uras, Giuseppe; Aslam, Muhammad; Pantaleo, Antonella

doi:10.3390/membranes12020205

Cited by 5 publications

(3 citation statements)

References 164 publications

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“…The glycocalyx is a dense macromolecular mesh composed of proteoglycans and glycosaminoglycans decorating the endothelial outer membrane, and has been shown to be both a primary mechanosensor and final effector for cellular adaptation to FSS ( Pahakis et al, 2007 ; Psefteli et al, 2021 ; Wang et al, 2020 ; Zeng and Tarbell, 2014 ; Zeng et al, 2018 ; Barvitenko et al, 2022 ) ( Fig. 2 ).…”

Section: Sensing Transduction and Subcellular Responses To Fluid Shea...mentioning

confidence: 99%

Response of cells and tissues to shear stress

Espina,

Cordeiro,

Milivojevic

et al. 2023

Journal of Cell Science

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Shear stress is essential for normal physiology and malignancy. Common physiological processes – such as blood flow, particle flow in the gut, or contact between migratory cell clusters and their substrate – produce shear stress that can have an impact on the behavior of different tissues. In addition, shear stress has roles in processes of biomedical interest, such as wound healing, cancer and fibrosis induced by soft implants. Thus, understanding how cells react and adapt to shear stress is important. In this Review, we discuss in vivo and in vitro data obtained from vascular and epithelial models; highlight the insights these have afforded regarding the general mechanisms through which cells sense, transduce and respond to shear stress at the cellular levels; and outline how the changes cells experience in response to shear stress impact tissue organization. Finally, we discuss the role of shear stress in collective cell migration, which is only starting to be appreciated. We review our current understanding of the effects of shear stress in the context of embryo development, cancer and fibrosis, and invite the scientific community to further investigate the role of shear stress in these scenarios.

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Section: Sensing Transduction and Subcellular Responses To Fluid Shea...mentioning

confidence: 99%

Response of cells and tissues to shear stress

Espina,

Cordeiro,

Milivojevic

et al. 2023

Journal of Cell Science

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“…The balance of anti- and proinflammatory factors determines the trend of the inflammatory response. Anti-inflammatory factors predominantly include IL-4/10/35 and transforming growth factor β (TGF-β); proinflammatory factors mainly include IL-1β/2/6/15/16/17; tumour necrosis factor (TNF); and interferon γ (IFN-γ) [ 98 – 100 ] . In this section, the production and secretion mechanisms of inflammatory factors in the SASP are discussed, and the epistemic regulatory mechanisms of the SASP are revealed, providing new ideas for the prevention and treatment of aging.…”

Section: Regulatory Role Of M 6 a In Cellular Sene...mentioning

confidence: 99%

m<sup>6</sup>A methylation in cellular senescence of age-associated diseases

Gao¹,

Yao²,

Pang³

et al. 2023

ABBS

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Cellular senescence is a state of irreversible cellular growth arrest that occurs in response to various stresses. In addition to exiting the cell cycle, senescent cells undergo many phenotypic alterations, including metabolic reprogramming, chromatin rearrangement, and senescence-associated secretory phenotype (SASP) development. Furthermore, senescent cells can affect most physiological and pathological processes, such as physiological development; tissue homeostasis; tumour regression; and age-associated disease progression, including diabetes, atherosclerosis, Alzheimer’s disease, and hypertension. Although corresponding anti-senescence therapies are actively being explored for the treatment of age-associated diseases, the specific regulatory mechanisms of senescence remain unclear. N 6 -methyladenosine (m 6 A), a chemical modification commonly distributed in eukaryotic RNA, plays an important role in biological processes such as translation, shearing, and RNA transcription. Numerous studies have shown that m 6 A plays an important regulatory role in cellular senescence and aging-related disease. In this review, we systematically summarize the role of m 6 A modifications in cellular senescence with regard to oxidative stress, DNA damage, telomere alterations, and SASP development. Additionally, diabetes, atherosclerosis, and Alzheimer’s disease regulation via m 6 A-mediated cellular senescence is discussed. We further discuss the challenges and prospects of m 6 A in cellular senescence and age-associated diseases with the aim of providing rational strategies for the treatment of these age-associated diseases.

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“…The review of Nadezhda Barvitenko et al [ 14 ] indicates that endothelial mechanosensors are the key upstream signaling proteins in shear stress (SS)-induced pro- and anti-inflammatory responses. As transmembrane proteins, mechanosensors not only experience fluid SS but also become regulated by the biomechanical properties of the lipid bilayer and the cytoskeleton.…”

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confidence: 99%