Endothelial Cell Function and Hypertension: Interactions Among Inflammation, Immune Function, and Exercise

Cook, Marc D.

doi:10.1007/978-3-319-17076-3_14

Cited by 2 publications

(1 citation statement)

References 105 publications

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“…Utilizing multiple individual primary HUVEC, a naïve EC line, lessens the impact of pre-existing factors from humans and permits identification of EC profiles related to racial/ethnic groups. This outcome in AA HUVEC is novel considering that reduced NOx bioavailability and ET-1 have been implicated in AA hypertension [25] and the effect that heightened inflammation has on EC function [26]. Further, A B vascular tissue [36].…”

Section: Endy Vascular Dysfunction and Regulation Of Mmp-2mentioning

confidence: 95%

Primary African American Endothelial Cells Exhibit Endothelial Dysfunction with an Exacerbated Inflammatory Profile and Blunted MMP-2 Activity

Cook¹,

Ling²,

Grimm³

et al. 2020

Artery Res

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African American (AA) race is an independent risk factor for vascular disease (e.g., hypertension) [1,2]. Hypertension disproportionately affects AAs, regardless of admixture [3], coupled with increased severity of hypertension and nearly a twofold increase in mortality associated with cardiovascular disease [4], thus revealing the epidemiological racial disparity and public health impact regarding hypertension [5,6]. Therefore, investigations are necessary to understand potential mechanism(s) that ultimately lead to premature and exacerbated hypertension-related cardiovascular diseases (e.g., stroke, kidney disease, hypertensive neuropathy, heart dysfunction) and end-organ failure in AA.Endothelial Dysfunction (EnDy), which can precede hypertension, has been shown to be greater in AA [7,8]. EnDy is characterized by a chronic low-grade inflammatory state of the endothelium and is marked by an exacerbated immune and oxidative stress response to inflammation. In vitro, Kalinowski et al. [1] showed that AA Human Umbilical Vein Endothelial Cells (HUVEC) exhibit EnDy marked by increased oxidative stress (e.g., superoxide and peroxynitrite production; Reactive Oxygen Species (ROS) and consequent reduced nitric oxide (NOx) bioavailability). Studies have previously shown that AA had significantly greater ROS in vitro and in vivo [9,10], and had greater circulating inflammatory endothelial microparticles (a novel biomarker of EnDy) [11,12]. One mechanistic explanation of these in vitro observations was that AA Endothelial Cells (EC) exhibited greater expression of nicotinamide adenine dinucleotide phosphate (NADPH) oxidase, increased basal inflammation, and lower antioxidant capacity [9] compared to Caucasian (CA) HUVEC that significantly improved in response to in vitro exercise mimetic (i.e., laminar shear stress)

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Section: Endy Vascular Dysfunction and Regulation Of Mmp-2mentioning

confidence: 95%

Primary African American Endothelial Cells Exhibit Endothelial Dysfunction with an Exacerbated Inflammatory Profile and Blunted MMP-2 Activity

Cook¹,

Ling²,

Grimm³

et al. 2020

Artery Res

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View full text Add to dashboard Cite

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Exercise and the Microbiome: Mechanistic Perspectives of the Impact of Exercise on the Gut-Vascular Axis

Cook

Hogue

2021

mSystems

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Given the participation of the microbiome in human health and disease, understanding the context of host-microbe interactions involved in vascular pathophysiology is now evolving through identifying microbial communities, specific taxa, and metabolic profiling which can be coupled to human health outcomes. Exercise has been used to define mechanisms related to improved vascular health, which may involve the microbiome.

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Endothelial Cell Function and Hypertension: Interactions Among Inflammation, Immune Function, and Exercise

Cited by 2 publications

References 105 publications

Primary African American Endothelial Cells Exhibit Endothelial Dysfunction with an Exacerbated Inflammatory Profile and Blunted MMP-2 Activity

Primary African American Endothelial Cells Exhibit Endothelial Dysfunction with an Exacerbated Inflammatory Profile and Blunted MMP-2 Activity

Exercise and the Microbiome: Mechanistic Perspectives of the Impact of Exercise on the Gut-Vascular Axis

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