2022
DOI: 10.1182/blood.2021011644
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Endothelial cell-derived angiopoietin-like protein 2 supports hematopoietic stem cell activities in bone marrow niches

Abstract: Bone marrow niche cells have been reported to fine-tune HSC stemness via direct interaction or secreted components. Nevertheless, how niche cells control HSC activities remains largely unknown. We previously showed that angiopoietin-like protein 2 (ANGPTL2) can support the ex vivo expansion of HSCs by binding to human leukocyte immunoglobulin-like receptor B2 (LILRB2). However, how ANGPTL2 from specific niche cell types regulates HSC activities under physiological conditions is still not clear. Herein, we gene… Show more

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Cited by 21 publications
(17 citation statements)
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References 76 publications
(85 reference statements)
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“…To measure the self-renewal ability of SRCs, the SCID-SRCs are transplanted into the non-obese diabetic SCID (NOD/SCID) mice. Results of the study showed that a serum-free culture including SCF, THPO and FGF-1 or Flt3-L cannot clearly amplify SRCs present in human cord blood CD133 cells [ 73 ]. However, when either angiopoietin-like protein 5 or IGF-binding protein 2 is included in the experiment, the expansion of HSCs becomes significant.…”
Section: Ex Vivo Expansion Of Hscsmentioning
confidence: 99%
“…To measure the self-renewal ability of SRCs, the SCID-SRCs are transplanted into the non-obese diabetic SCID (NOD/SCID) mice. Results of the study showed that a serum-free culture including SCF, THPO and FGF-1 or Flt3-L cannot clearly amplify SRCs present in human cord blood CD133 cells [ 73 ]. However, when either angiopoietin-like protein 5 or IGF-binding protein 2 is included in the experiment, the expansion of HSCs becomes significant.…”
Section: Ex Vivo Expansion Of Hscsmentioning
confidence: 99%
“…In this issue of Blood, Yu et al demonstrate that angiopoietin-like 2 (ANGPTL2) secreted by the vascular niche endothelial cells serves as the seminal paracrine angiocrine factor, orchestrating hematopoietic stem cell (HSC) homeostasis and regeneration after myelosuppression. 1 Tissue-specific endothelium, such as BM endothelial cells (BMECs), is endowed with unique organotypic specialized functions, including modulation of metabolism, immune cell trafficking, inflammatory response, vascular tone, regeneration, and repair. 2,3 It is well documented that blood vessels in the BM are not just passive conduits delivering nutrients and oxygen to hematopoietic cells.…”
Section: Shahin Rafii and Raphael Lis | Weill Cornell Medicinementioning
confidence: 99%
“…The cellular and molecular components of the niche for hematopoietic stem cells (HSCs) are still not well defined. Angiopoietin-like proteins (Angptls) are a group of secreted glycoproteins that have been reported to play various roles, including the regulation of HSC activity 1 . Specifically, Angptl2, a member of the Angptl family, was demonstrated to support HSC stemness through binding to inhibitory receptors 2 .…”
mentioning
confidence: 99%
“…Yu et al used an elegant approach to study these questions 1 . Based on the expression pattern of Angptl2 in bone marrow, several conditional knockout (KO) mice were generated to deplete Angptl2 from endothelial, mesenchymal stromal cells, megakaryocytes, and HSCs.…”
mentioning
confidence: 99%
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