Endothelial cell-dependent relaxation and contraction induced by histamine in the isolated guinea-pig pulmonary artery

Satoh, Hiroyuki; Inui, Jun

doi:10.1016/0014-2999(84)90468-0

Cited by 85 publications

(45 citation statements)

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“…Further, depending on the species and the vessels,, this endothelium-dependent relaxation occurs through activation of H2-receptors ( Van de Voorde & Leusen, 1984;Sercombe et al, 1986) and/or H1-receptors (Satoh & Inui, 1984;Abacioglu et al, 1987;Szarek et al, 1992) located on the endothelial cells resulting in a subsequent release of inhibitory substances. In the present experiments, precontracted pulmonary arteries exhibited a biphasic response to histamine.…”

Section: Discussionmentioning

confidence: 99%

Characterization of the histamine receptors in the guinea‐pig lung: evidence for relaxant histamine H₃ receptors in the trachea

Cardell

Edvinsson

1994

British J Pharmacology

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1 The histamine receptors were characterized on isolated circular segments of trachea and pulmonary arteries from the guinea-pig. The motor responses to histamine HI-, H2-and H3-receptor agonists and antagonists were tested and the responses obtained were analysed in relation to the respiratory epithelium and the vascular endothelium. 2 Histamine induced a biphasic response in trachea and in pulmonary arteries. In low concentrations, histamine acted as a potent relaxant agent of precontracted segments and in moderate concentrations it constricted both precontracted and resting segments. When arterial segments from different parts of the pulmonary vascular tree were compared, only small interregional differences in the vasomotor response were seen. 3 Mepyramine caused a parallel shift to the right of the histamine-induced concentration-response curves for both the trachea and the pulmonary artery, indicating a contractile HI-receptor. Cimetidine did not affect the histamine-induced contraction of the trachea, but a shift to the left was evident for low concentrations of histamine in the pulmonary artery. This is consistent with a dilator H2-receptor in the pulmonary artery. The pA2-value for mepyramine in the pulmonary artery, 8.75, was not affected by the presence of cimetidine. Thioperamide, a selective H3 antagonist, shifted the concentration-response for the trachea to the left. Schild analysis for histamine and mepyramine yielded a line with a slope of 0.61, whereas the same analysis in the presence of thioperamide yielded a line with a slope of 1.05 and an approximated pA2-value of 9.57. These results indicate the presence of a relaxant H3 receptor in the trachea. In precontracted tracheal segments, application of mepyramine and cimetidine did not affect the low dose histamine relaxation. Thioperamide caused a parallel shift of the histamine concentrationresponse curve to the right, supporting the suggestion of a dilator H3-receptor in the trachea. The pA2-value for thioperamide, in the presence of mepyramine, was 7.79. In precontracted pulmonary arteries the histamine-induced dilatation was small. In the presence of mepyramine a rather strong histamine-induced dilatation became evident and this concentration-response curve could be shifted to the right by cimetidine, with a pA2-value of 6.49. This is compatible with a dilator H2-receptor. 4 The H1-receptor agonists, thiazolylethylamine, 2-methylhistamine and pyridylethylamine and the rather unselective H2-agonist, 4-methylhistamine, induced contraction of resting tracheal and pulmonary arterial segments. In precontracted segments of trachea, all H1 and H2 agonists studied induced a dilator response. The two rather unselective histamine receptor agonists 2-methylhistamine and 4-methylhistamine were about 100 times more potent than other H1 and H2 agonists tested. In the pulmonary artery, the H2 agonists, impromidine, dimaprit and 4-methylhistamine induced a concentration-dependent relaxation. The relaxation of the pulmonary artery, elicited by the H1 a...

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Section: Discussionmentioning

confidence: 99%

Characterization of the histamine receptors in the guinea‐pig lung: evidence for relaxant histamine H₃ receptors in the trachea

Cardell

Edvinsson

1994

British J Pharmacology

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“…Remarkable species differences have been reported concerning the responsiveness of coronary vessels to histamine in vitro. Coronary arteries from monkeys and dogs respond to histamine with relaxations (1, 2), while human, pig and cattle coronary arteries respond with contractions (3-6).It has been postulated that the species difference might depend on the ability of histamine to activate H1-and H2-receptors in vascular smooth muscle and H1-receptors in endothelium, which possibly mediate the release of prostaglandin 12 (7, 8) or endothelium-derived relaxing factors (1,9,10 …”

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confidence: 99%

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confidence: 99%

“…It has been postulated that the species difference might depend on the ability of histamine to activate H1-and H2-receptors in vascular smooth muscle and H1-receptors in endothelium, which possibly mediate the release of prostaglandin 12 (7,8) or endothelium-derived relaxing factors (1,9,10 solution (119 mM NaC1, 4.7 mM KCI, 1.6 mM CaCl2, 1.2 mM MgC12, 25 mM NaHCO3, 1.2 mM KH2PO4, and 10.0-mM glucose) aerated with a mixture of 95%02 and 5% CO2. The middle part of the left descending coronary arteries was dissected free and cleaned of adhering tissue, and two rings about 3 mm in length were cut.…”

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confidence: 99%

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Vasomotor effect of histamine on pig and cattle coronary artery in vitro.

Obi¹,

Matsumoto

Nishio

1991

Jpn.J.Pharmacol

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ABSTRACT-Vasomotor effects of histamine were examined in isolated coronary arteries from pigs and cattle. Histamine produced a concentration-dependent contraction in these arteries. These contractile responses were dose-dependently inhibited by diphenhydramine. The slopes of the Schild plots, however, were significantly lower than unity in both species. Cimetidine potentiated the histamine-induced contractions at relatively high doses of histamine (larger than 10-5 M) in pig coronary arteries, but did not show a significant effect in cattle arteries. After the removal of endothelium, the Schild plot of diphenhydramine against histamine gave a straight line with a pA2 value of 7.80 and slope of 1.00 in pigs, confirming the competitive nature of the antagonism. In cattle, the slope was significantly lower than unity; however, in the presence of cimetidine, it was not significantly different from unity. Dimaprit did not contract the cattle coronary arteries with endothelium, but contracted them after the removal of endothelium. These results suggest that histamine-induced vasoconstriction in pig and cattle coronary arteries is mainly dependent on the Hi-receptors in the smooth muscle cells, and that H1-and H2-receptors in the endothelial cells of pigs and H2-receptors in the smooth muscle cells of cattle modify the histamine-induced vasoconstrictions. Remarkable species differences have been reported concerning the responsiveness of coronary vessels to histamine in vitro. Coronary arteries from monkeys and dogs respond to histamine with relaxations (1, 2), while human, pig and cattle coronary arteries respond with contractions (3-6).It has been postulated that the species difference might depend on the ability of histamine to activate H1-and H2-receptors in vascular smooth muscle and H1-receptors in endothelium, which possibly mediate the release of prostaglandin 12 (7, 8) or endothelium-derived relaxing factors (1,9,10

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“…vasodilator factor(s) released from endothelial cells (Furchgott & Zawadzki, 1980). Histamine relaxes dog mesenteric arteries, due partly to the release of prostaglandin I2 (PGI2) from endothelium Toda, 1984) and relaxes rat aortae and guineapig pulmonary arteries as a result of the release of endothelium-derived relaxing factor(s) (Van de Voorde & Leusen 1983;Satoh & Inui, 1984). However, whether or not endothelial functions alter with age has not been clarified.…”

Section: Introductionmentioning

confidence: 99%

Alterations with age of the response to vasodilator agents in isolated mesenteric arteries of the beagle

Shimizu

Toda

1986

British J Pharmacology

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1 Responses to vasodilator agents were compared in helical strips ofmesenteric arteries from beagles of different ages (30 days, 3 months, 2 years and 12 years old), precontracted with prostaglandin F2% (PGFu). Relaxations induced by isoprenaline and adenosine were related inversely to age, whereas those induced by PGI2 and K+ (5 mM) did not alter with age. 2 Acetylcholine-induced relaxations were less in the arteries from the aged (12 year old) beagles than in those from the younger beagles. Histamine-induced relaxations related directly to age between 30 days and 2 years. Acetylcholine-induced relaxation was reversed to a contraction in infant (30 day old) beagle arteries by removal of the endothelium, and significantly attenuted in the older beagle arteries. In adult (2 year old) and aged beagle arteries, removal of the endothelium attenuated the histamineinduced relaxation. Treatment with indomethacin reversed the histamine-induced relaxation to a marked contraction in aged beagle arteries.3 It may be concluded that responses mediated by B-adrenoceptors and PI-purinoceptors are less in aged mesenteric arteries than in those from the younger beagles, whereas responses mediated by PGI2 receptors and the electrogenic Na+ pump do not alter with age. The release of endothelium-derived relaxing factor(s) by acetylcholine appears to be inversely related to age. However, the release of PGI2 possibly caused by histamine may be less in infant beagle mesenteric arteries than in those from the older beagles.

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Endothelial cell-dependent relaxation and contraction induced by histamine in the isolated guinea-pig pulmonary artery

Cited by 85 publications

References 4 publications

Characterization of the histamine receptors in the guinea‐pig lung: evidence for relaxant histamine H₃ receptors in the trachea

Characterization of the histamine receptors in the guinea‐pig lung: evidence for relaxant histamine H₃ receptors in the trachea

Vasomotor effect of histamine on pig and cattle coronary artery in vitro.

Alterations with age of the response to vasodilator agents in isolated mesenteric arteries of the beagle

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Endothelial cell-dependent relaxation and contraction induced by histamine in the isolated guinea-pig pulmonary artery

Cited by 85 publications

References 4 publications

Characterization of the histamine receptors in the guinea‐pig lung: evidence for relaxant histamine H3 receptors in the trachea

Characterization of the histamine receptors in the guinea‐pig lung: evidence for relaxant histamine H3 receptors in the trachea

Vasomotor effect of histamine on pig and cattle coronary artery in vitro.

Alterations with age of the response to vasodilator agents in isolated mesenteric arteries of the beagle

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Characterization of the histamine receptors in the guinea‐pig lung: evidence for relaxant histamine H₃ receptors in the trachea

Characterization of the histamine receptors in the guinea‐pig lung: evidence for relaxant histamine H₃ receptors in the trachea