Endothelbiologie und Exosomen – eine Hommage auf Theresa Maria Listowska Whiteside

Ludwig, Nils; Lotze, Michael T.

doi:10.1007/s00106-019-00803-1

Cited by 2 publications

(1 citation statement)

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“…Also, TEX-associated long noncoding RNAs (lncRNAs) were reported to promote angiogenesis. The transfer of long intergenic noncoding RNA CCAT2 to ECs by TEX enhanced in vitro and in vivo angiogenesis and upregulated VEGFA and TGF-β levels on ECs [41]. It seems that the pro-angiogenic effects of TEX on ECs are orchestrated via multiple pathways which probably converge, therefore, making TEX efficacious promotors of angiogenesis.…”

Section: Effects Of Tex On Endothelial Cellsmentioning

confidence: 99%

Potential Roles of Tumor Cell- and Stroma Cell-Derived Small Extracellular Vesicles in Promoting a Pro-Angiogenic Tumor Microenvironment

Ludwig

Rubenich

Zaręba

et al. 2020

Cancers

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Extracellular vesicles (EVs) are produced and released by all cells and are present in all body fluids. They exist in a variety of sizes, however, small extracellular vesicles (sEVs), the EV subset with a size range from 30 to 150 nm, are of current interest. They are characterized by a distinct biogenesis and complex cargo composition, which reflects the cytosolic contents and cell-surface molecules of the parent cells. This cargo consists of proteins, nucleic acids, and lipids and is competent in inducing signaling cascades in recipient cells after surface interactions or in initiating the generation of a functional protein by delivering nucleic acids. Based on these characteristics, sEVs are now considered as important mediators of intercellular communication. One hallmark of sEVs is the promotion of angiogenesis. It was shown that sEVs interact with endothelial cells (ECs) and promote an angiogenic phenotype, ultimately leading to increased vascularization of solid tumors and disease progression. It was also shown that sEVs reprogram cells in the tumor microenvironment (TME) and act in a functionally cooperative fashion to promote angiogenesis by a paracrine mechanism involving the differential expression and secretion of angiogenic factors from other cell types. In this review, we will focus on the distinct functions of tumor-cell-derived sEVs (TEX) in promotion of angiogenesis and describe their potential as a therapeutic target for anti-angiogenic therapies. Also, we will focus on non-cancer stroma-cell-derived small extracellular vesicles and their potential role in stimulating a pro-angiogenic TME.

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Section: Effects Of Tex On Endothelial Cellsmentioning

confidence: 99%