Endotelial dysfunction in condition of neoplastic intoxication

Abstract

In patients with cancer, the risk of pulmonary embolism increases 4-7 times compared to other patients of the same age and similar concomitant diseases. The greatest risk exists after surgery and during chemotherapy. An increase in the risk of thrombosis in cancer patients is a multifactorial complex phenomenon, the causes of which are an increase in the number of platelets, changes in the rheological properties of blood, as well as reactive structural changes in the vascular wall, valves and endotheliocytes. The latter factor of pathogenesis is insufficiently studied and is not used to assess the risks of thrombosis and prevent thrombosis in cancer patients. However, this topic is promising in the search for opportunities to study the pathogenesis of pulmonary embolism, and, accordingly, to assess the risks in different groups of patients and methods of prevention and options for clinical tactics in cases of venous thrombosis.Objective. To find out the dynamics of the concentration of lipid peroxidation products, in particular the activity of phospholipase and catalase in experimental neoplastic intoxication. Material and methods. For the experiment, 12 sexually mature nonlinear male rats with a body weight of 170-180 g were selected. by injecting 7.2 mg/kg into the rat interscapular area at the rate of 0.1 ml of dimethylhydrazine hydrochloride (DMG) solution 1.2 – DMG (SIGMA-ALDRICH CHEMIE, Japan, D161802 series), previously diluted with isotonic sodium chloride solution per 10 grams of rat body weight, a tumor was modeled intoxication. On day 30 of the experiment, the animals were sacrificed, and the material of the venous wall of the lower extremities was studied for the morphological structure of the vascular wall.Results and Discussion. Morphological examination of the drug revealed platelet thinning, desquamation and microscopic reorganization of endotheliocytes, focal loss of endothelial layer integrity, and wavy thickening of the intima. This complex of phenomena can be the basis of the pathogenesis of thrombosis in combination with a violation of hemodynamics and rheological properties of blood. On day 30 of the experiment, a morphological study of the drug was performed on the venous wall of rats.Conclusions. Changes that were detected after modeling chronic tumor intoxication include endothelium changes in the form of desquamation and reorganization, violation of the integrity of the endothelial layer, wavy thickening of the intima, fibrotic changes in all the membranes of the vessel.