Endosulfan Toxicity and Dietary Protein

Administration of endosulfan significantly increased microsomal protein, cytochrome P-450 content and the activity of aminopyrine N-demethylase. Effect of endosulfan and actinomycin D either alone or together on microsomal protein, cytochrome P-450, NADPH cytochrome c reductase, aniline hydroxylase, aminopyrine N-demethylase, phosphatidylcholine content, incorporation of 3H-choline and 14C-methionine were studied in rats given amino acid deficient and supplemented diets. Administration of endosulfan significantly increased the above parameters in both the dietary groups, whereas administration of actinomycin D did not have any effect in rats fed supplemented diets, however, significant decrease in the PC and the incorporation of choline and methionine into PC of rats fed deficient diet were observed. A positive correlation in the effect of endosulfan on hepatic mixed function oxidase activity and hepatic phosphatidylcholine is observed.

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“…(Tyagi et al 1984). It has been reported that the toxicity of endosulfan is inversely related to quantity of dietary protein (Boyd et al 1970).…”

Section: Tablementioning

confidence: 99%

“…In contrast Agarval et al (1978) reported that endosulfan induced the activities of some mixed function oxidases. The toxicity of endosulfan has been inversely related to the quantity and quality of, the protein in the diets (Boyd et al 1970, Tyagi et al 1984. The reasons for the discrepancy in the reports of these workers is not clear.…”

mentioning

confidence: 96%

Induction of cytochrome p‐450 and phosphatidylcholine synthesis by endosulfan in liver of rats : Effect of quality of dietary proteins

Tyagi

Sriram

Narayan

et al. 1985

Journal of Environmental Science and Health, Part B

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“…[For water, see (3).] In the case of food, low-protein diets, or better, diets devoid of protein, resulted in the greatly increased lethality of several pesticides for rats (16). However, companion studies for effects under realistic environmental conditions were not performed; nor has anyone considered the question of how human beings on such -a diet would be exposed to significant levels of pesticides.…”

Section: Commandmentmentioning

confidence: 99%

Sanity in Research and Evaluation of Environmental Health

Stokinger

1971

Science

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“…Those who have suffered occupational exposure to endosulfan has been reported to exhibit convulsions, epilepsy, hyperactivity, irritability, tremor, and paralysis (Aleksandrowicz, 1979;Agrawal et al, 1983;Naqvi and Vaishnavi, 1993), as well as neurobehavioral symptoms manifested by agitation, memory defects, partial aphasia, limited cognition (Aleksandrowicz, 1979), impairment of motor coordination, and mental confusion (Ely et al, 1967;Paul et al, 1994). Cerebral congestion and edema have often been observed at necropsy of animals and autopsy of humans who died following acute ingestion of endosulfan (Boyd and Dobos, 1969;Boyd et al, 1970;Terziev et al, 1974;Boereboom et al, 1998;ATSDR, 2000;Eyer et al, 2004).…”

Section: Introductionmentioning

confidence: 99%

Development of anin vitro blood–brain barrier model to study the effects of endosulfan on the permeability of tight junctions and a comparative study of the cytotoxic effects of endosulfan on rat and human glial and neuronal cell cultures

et al. 2006

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Endosulfan, an organochlorine (OC) insecticide that belongs to the cyclodiene group, is one of the most commonly used pesticides to control pests in vegetables, cotton, and fruits. Porcine brain microvascular endothelial cells were used to develop a model to study the effects of endosulfan on the permeability of tight junctions in the blood-brain barrier (BBB). BBB permeability, measured as transendothelial electrical resistance, decreased in a dose- and time-dependent manner when treated with alpha-endosulfan, beta-endosulfan, or endosulfan sulfate. Cytotoxicity testing revealed that the three endosulfans did not cause cell death at concentrations of 10 microM and below. The ratio of the average permeability of the filter-grown endothelial cell monolayer to 14C-endosulfan (Pe) going from the outer to the inner compartments with that going from the inner to the outer compartments was approximately 1:1.2-2.1 after exposure to concentrations of 0.01-10 microM. alpha-Endosulfan, beta-endosulfan, and endosulfan sulfate had cytotoxic effects on rat glial (C6) and neuronal (PC12) cell cultures as well as on human glial (CCF-STTG1) and neuronal (NT2) cell cultures. The effects of alpha-endosulfan were highly selective, with a wide range of LC50 values found in the different cultures, ranging from 11.2 microM for CCF-STTG1 cells to 48.0 microM for PC12 cells. In contrast, selective neurotoxicity was not so manifest in glial and neuronal cell cultures after exposure to endosulfan sulfate, as LC50 values were in the range of 10.4-21.6 microM. CCF-STTG1 cells were more sensitive to alpha-endosulfan and endosulfan sulfate, whereas NT2 cells were more sensitive to beta-endosulfan.

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Endosulfan Toxicity and Dietary Protein

Cited by 16 publications

References 10 publications

Induction of cytochrome p‐450 and phosphatidylcholine synthesis by endosulfan in liver of rats : Effect of quality of dietary proteins

Induction of cytochrome p‐450 and phosphatidylcholine synthesis by endosulfan in liver of rats : Effect of quality of dietary proteins

Sanity in Research and Evaluation of Environmental Health

Development of anin vitro blood–brain barrier model to study the effects of endosulfan on the permeability of tight junctions and a comparative study of the cytotoxic effects of endosulfan on rat and human glial and neuronal cell cultures

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