Endosteal bone formation following vascular obstruction

Abstract

Partial occlusion of the periodontal microvasculature was achieved by introducing black carbonized microspheres unilaterally into the external carotid artery of squirrel monkeys. The contralateral side of the animal served as its own control. One week following the vascular obstruction, tritiated 2‐glycine was injected intraperitoneally to label newly formed endosteal bone. All animals were sacrificed four weeks following the injection of tritiated glycine. The jaws were removed, hemi‐sected, fixed, decalcified, and sectioned bucco‐lingually through the interdental areas (cols). Autoradiography was performed on tissue sections selected from the posterior col areas of the experimental and control sides. Measurements were made from sections of interdental labelled and unlabelled endosteal bone surfaces. Less endosteal bone formation was evident on the experimental side following the vascular insult.

Blood flow and periodontal destruction in normal and atherosclerotic rhesus monkeys

“…Our findings that a reduction of blood flow was significantly correlated with loss of crestal height for both groups of animals and with a more apical junctional epithelium in the atherosclerotic group suggests that blood flow is an important factor in periodontal destruction. These results are in accord with the study of Vandersall and Kennedy (1970) who found significantly reduced interdental bone formation in squirrel monkeys after occlusion of the periodontal microvasculature. Whether this effect reflects reduced bone apposition or increased resorption is uncertain although it has been claimed that an impaired periodontal circulation both stimulates resorption of alveolar bone and prevents osteogenesis (Reichborn-Kjennnerud 1963).…”

Functionalization of titanium implants using a modular system for binding and release of VEGF enhances bone‐implant contact in a rodent model

“…Vascularization is a key condition for the process of bone healing. In bone regeneration and remodelling, vascularization significantly affects the velocity and the level of new bone formation (Vandershall & Kennedy , Trueta , Deitz et al. ).…”

Diagnosis and childhood firesetting

“…Yarnell (1940) and subsequent investigators found firesetters to have problems that ranged from psychosis and conduct disorder to adjustment reactions. The majority of the younger firesetters exhibited conduct problems, and it was postulated that adolescent firesetters had sexual problems (Kaufman, Heims, & Reiser, 1961;Lewis & Yarnell, 1951;Macht & Mack, 1968;Nurcombe, 1964;Vandersall & Weiner, 1970). While these early papers and studies added to our knowledge of firesetting and firesetters, they seldom employed randomization, appropriate comparison groups, or accepted diagnostic schema such as the DSM-I1 or DSM-111 to describe their diagnostic impressions.…”