Endostatin attenuates PDGF-BB- or TGF-&amp;beta;1-induced HSCs activation via suppressing RhoA/ROCK1 signal pathways

Ren, Haitao; Li, Yuan; Yan, Chen; Wang, Liang

doi:10.2147/dddt.s191617

Cited by 16 publications

(7 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The increased type XVIII collagen upregulates its own product, EST. EST is able to resist liver fibrosis by inhibiting the expression of TGF‐β1 mRNA through RhoA/ROCK signal pathways in hepatic stellate cells (HSCs) 47,48 . In addition, liver fibrosis refers to the progression of extracellular matrix excessive deposition, which is often promoted by the activation of HSCs.…”

Section: Discussionmentioning

confidence: 99%

Collagen type XVIII alpha 1 chain (COL18A1) variants affect the risk of anti‐tuberculosis drug‐induced hepatotoxicity: A prospective study

Jiao

Wang

et al. 2020

Clinical Laboratory Analysis

View full text Add to dashboard Cite

Background The role of collagen type XVIII alpha 1 chain (COL18A1) in anti‐tuberculosis drug‐induced hepatotoxicity (ATDH) has not been reported. This study aimed to explore the association between of COL18A1 variants and ATDH susceptibility. Methods A total of 746 patients were enrolled in our study from December 2016 to April 2018, and all subjects in the study signed an informed consent form. The custom‐by‐design 2x48‐Plex SNPscanTM kit was used to genotype all selected 11 SNPs. Categorical variables were compared by chi‐square (χ2) or Fisher's exact test, while continuous variables were compared by Mann‐Whitney's U test. Plink was utilized to analyze allelic and genotypic frequencies, and genetic models. Multivariate logistic regression analyses were used to adjust potential factors. The odds ratios (ORs) with corresponding 95% confidence intervals (CIs) were also calculated. Results Among patients with successfully genotyping, there were 114 cases and 612 controls. The mutant A allele of rs12483377 conferred the decreased risk of ATDH (OR = 0.13, 95%CI: 0.02–0.98, P = 0.020), and this significance still existed after adjusting age and gender (P = 0.024). The mutant homozygote AA genotype of rs12483377 was associated with decreased total protein levels (P = 0.018). Conclusion Our study first revealed that the A allele of COL18A1 rs12483377 was associated with the decreased risk of ATDH in the Western Chinese Han population, providing new perspective for the molecular prediction, precise diagnosis, and individual treatment of ATDH.

show abstract

Section: Discussionmentioning

confidence: 99%

Collagen type XVIII alpha 1 chain (COL18A1) variants affect the risk of anti‐tuberculosis drug‐induced hepatotoxicity: A prospective study

Jiao

Wang

et al. 2020

Clinical Laboratory Analysis

View full text Add to dashboard Cite

show abstract

“…It is also involved in the development of liver diseases (i.e., nonalcoholic steatohepatitis and hepatocellular carcinoma) [409], whereas endostatin is antifibrotic [410]. Canstatin is anti‐lymphangiogenic and modulates voltage‐dependent calcium channel activity in rat cardiomyocytes [411], and endostatin‐derived peptides are antifibrotic [410]. ECM bioactive (matricryptins and matrikines) have potential applications in therapeutics, tissue engineering [402,412], and cosmetics [413].…”

Section: The Collagen Family: From Tissue Design To the Regulation Of Biological Processesmentioning

confidence: 99%

A guide to the composition and functions of the extracellular matrix

et al. 2021

View full text Add to dashboard Cite

Extracellular matrix (ECM) is a dynamic 3‐dimensional network of macromolecules that provides structural support for the cells and tissues. Accumulated knowledge clearly demonstrated over the last decade that ECM plays key regulatory roles since it orchestrates cell signaling, functions, properties and morphology. Extracellularly secreted as well as cell‐bound factors are among the major members of the ECM family. Proteins/glycoproteins, such as collagens, elastin, laminins and tenascins, proteoglycans and glycosaminoglycans, hyaluronan, and their cell receptors such as CD44 and integrins, responsible for cell adhesion, comprise a well‐organized functional network with significant roles in health and disease. On the other hand, enzymes such as matrix metalloproteinases and specific glycosidases including heparanase and hyaluronidases contribute to matrix remodeling and affect human health. Several cell processes and functions, among them cell proliferation and survival, migration, differentiation, autophagy, angiogenesis, and immunity regulation are affected by certain matrix components. Structural alterations have been also well associated with disease progression. This guide on the composition and functions of the ECM gives a broad overview of the matrisome, the major ECM macromolecules, and their interaction networks within the ECM and with the cell surface, summarizes their main structural features and their roles in tissue organization and cell functions, and emphasizes the importance of specific ECM constituents in disease development and progression as well as the advances in molecular targeting of ECM to design new therapeutic strategies.

show abstract

“…Endostatin is reported to inhibit the RhoA/ROCK pathway. Recent findings confirm that endostatin suppresses HSCs activation by inhibiting RhoA/ROCK1 signaling pathway (Ren et al 2019). HSCs can be triggered by factors like inflammation or injury.…”

Section: Rhoa/rock Pathwaymentioning

confidence: 68%

Endostatin in fibrosis and as a potential candidate of anti-fibrotic therapy

et al. 2021

View full text Add to dashboard Cite

Fibrotic diseases pose significant clinical challenges due to their broadness and complexity. Thus, a better understanding of fibrogenesis and the development of more effective treatments is imperative. Recent evidence suggests a significant antifibrotic potential of an endogenous glycoprotein, endostatin. While endostatin has been widely studied for its role as an anticancer adjuvant by inhibiting tumor angiogenesis, its possible implication in fibrosis remains largely unclear. Here, we review the role of endostatin in various cellular processes and highlight its antifibrotic activity. We hypothesize that endostatin conveys a homeostatic function in the process of fibrosis by regulating (a) TGF-β1 and its downstream signaling; (b) RhoA/ROCK pathway; (c) NF-κB signaling pathway; (d) expression of EGR-1; (e) PDGF/PDGFR pathway; (f) autophagy-related pathways; (g) pathways associated with cell proliferation and apoptosis. Finally, we propose a schematic model of the antifibrotic roles and mechanisms of endostatin; also, we outline future research directions of endostatin and aim to present a potential therapeutic approach for fibrosis.

show abstract

Endostatin attenuates PDGF-BB- or TGF-β1-induced HSCs activation via suppressing RhoA/ROCK1 signal pathways

Cited by 16 publications

References 21 publications

Collagen type XVIII alpha 1 chain (COL18A1) variants affect the risk of anti‐tuberculosis drug‐induced hepatotoxicity: A prospective study

Collagen type XVIII alpha 1 chain (COL18A1) variants affect the risk of anti‐tuberculosis drug‐induced hepatotoxicity: A prospective study

A guide to the composition and functions of the extracellular matrix

Endostatin in fibrosis and as a potential candidate of anti-fibrotic therapy

Contact Info

Product

Resources

About