Endosomal toll-like receptor gene polymorphisms and susceptibility to HIV and HCV co-infection – Differential influence in individuals with distinct ethnic background

Valverde-Villegas, Jacqueline María; Santos, Bruno Paiva dos; Medeiros, Rúbia Marília de; Mattevi, Vanessa Suñé; Lazzaretti, Rosmeri Kuhmmer; Sprinz, Eduardo; Kuhmmer, Regina

doi:10.1016/j.humimm.2017.01.001

Cited by 22 publications

(13 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Treatment is the next expected step after an infectious disease is diagnosed. The treatment of infectious diseases has a pivotal effect on the life quality of infected individuals, reducing unwanted impacts of the disease on social and economic aspects, along with the avoidance of possible coinfection-related complications for the patient, such as for those co-infected with HIV and hepatitis C virus (Da Silva et al, 2014;Valverde-Villegas et al, 2017a). The treatment of infections is also essential for controlling certain diseases at the population level.…”

Section: Treatmentmentioning

confidence: 99%

“…Our research group has already made several contributions regarding the role of host genetics on infectious diseases. For example, we have already investigated the impact of polymorphisms of the TLR-9, HLA-G and CCR5 genes on viral hepatitis (Da Silva et al, 2014;Valverde-Villegas et al, 2017a;Ellwanger et al, 2020c). These studies helped to understand, for example, which populations have differences in susceptibility to these infections.…”

Section: Impacts Of Host Genetics On Susceptibility To Infections Andmentioning

confidence: 99%

See 1 more Smart Citation

Control and prevention of infectious diseases from a One Health perspective

et al. 2021

Self Cite

View full text Add to dashboard Cite

The ongoing COVID-19 pandemic has caught the attention of the global community and rekindled the debate about our ability to prevent and manage outbreaks, epidemics, and pandemics. Many alternatives are suggested to address these urgent issues. Some of them are quite interesting, but with little practical application in the short or medium term. To realistically control infectious diseases, human, animal, and environmental factors need to be considered together, based on the One Health perspective. In this article, we highlight the most effective initiatives for the control and prevention of infectious diseases: vaccination; environmental sanitation; vector control; social programs that encourage a reduction in the population growth; control of urbanization; safe sex stimulation; testing; treatment of sexually and vertically transmitted infections; promotion of personal hygiene practices; food safety and proper nutrition; reduction of the human contact with wildlife and livestock; reduction of social inequalities; infectious disease surveillance; and biodiversity preservation. Subsequently, this article highlights the impacts of human genetics on susceptibility to infections and disease progression, using the SARS-CoV-2 infection as a study model. Finally, actions focused on mitigation of outbreaks and epidemics and the importance of conservation of ecosystems and translational ecology as public health strategies are also discussed.

show abstract

Section: Treatmentmentioning

confidence: 99%

Section: Impacts Of Host Genetics On Susceptibility To Infections Andmentioning

confidence: 99%

Control and prevention of infectious diseases from a One Health perspective

et al. 2021

Self Cite

View full text Add to dashboard Cite

show abstract

“…Interestingly, the rs3764880 G allele is also differentially associated with HIV status in distinct human populations (49,50). In addition, this allele protects against tissue damage in active tuberculosis (51,52).…”

Section: Discussionmentioning

confidence: 99%

p53-responsive TLR8 SNP enhances human innate immune response to respiratory syncytial virus

Menéndez¹,

Snipe²,

Marzec

et al. 2019

Journal of Clinical Investigation

View full text Add to dashboard Cite

“…The study of a functional TLR7 variant (rs179008) in 2009 reported that TLR7 Gln11Leu was associated with susceptibility to and a more severe clinical course of HIV-1 disease (25). Valverde-Villegas has reported that the polymorphisms of TLR7, TLR8, TLR9 contributed to susceptibility to HIV infection in Brazilian individuals with European and African descendants, which highlighted the influence of ethnic background on the susceptibility to HIV infection (26). So far, there has been no report on the association of TLR7 SNPs and HIV infection in Chinese people.…”

Section: Introductionmentioning

confidence: 99%

Effects of TLR7 Polymorphisms on the Susceptibility and Progression of HIV-1 Infection in Chinese MSM Population

Zhang

Zhu

et al. 2020

Front. Immunol.

View full text Add to dashboard Cite

Toll-like receptor (TLR) 7 plays a key role in innate and adaptive immunity for HIV-1 infection. We evaluated the effect of TLR7 polymorphisms on disease susceptibility and progression of HIV-1 infection in Chinese MSM (men who have sex with men). Blood samples were taken from 270 patients with laboratory confirmed HIV infection, 196 male controls were tested, and three TLR7 intronic polymorphisms (rs179010-C > T, X:12884766; rs2074109-T > C, X:12885330; and rs179009-A > G, X:12885361) were analyzed by PCR-based sequencing. The frequency of TLR7 rs179010 T allele was significantly lower in MSM patients than in controls (P = 0.039). The haplotype TTA was associated with a decreased susceptibility to HIV-1 infection (P = 0.013), especially to acute HIV-1 infection (AHI) (P = 0.002), but not to chronic HIV-1 infection (CHI). Furthermore, the haplotype TTA is linked to slow disease progression in AHI patients (P = 0.002) and a lower viral load (P = 0.042). In contrast, TLR7 rs179009 allele A contributed to a higher set point in AHI patients with rapid progression, and the frequency of rs179009 minor allele G was over-presented in CHI patients. This finding supports a role for genetic variations of TLR7 in susceptibility and disease progression of an HIV-1 infection in Chinese Han population and warrants further studies on the effect of TLR7 polymorphisms on HIV-1 infection in different populations.

show abstract

Endosomal toll-like receptor gene polymorphisms and susceptibility to HIV and HCV co-infection – Differential influence in individuals with distinct ethnic background

Cited by 22 publications

References 36 publications

Control and prevention of infectious diseases from a One Health perspective

Control and prevention of infectious diseases from a One Health perspective

p53-responsive TLR8 SNP enhances human innate immune response to respiratory syncytial virus

Effects of TLR7 Polymorphisms on the Susceptibility and Progression of HIV-1 Infection in Chinese MSM Population

Contact Info

Product

Resources

About