Endosomal actin branching, fission and receptor recycling require FCHSD2 recruitment by MICAL-L1
Devin Frisby,
Ajay B. Murakonda,
Bazella Ashraf
et al.
Abstract:Endosome fission is required for the release of carrier vesicles and the recycling of receptors to the plasma membrane. Early events in endosome budding and fission rely on actin branching to constrict the endosomal membrane, ultimately leading to nucleotide hydrolysis and enzymatic fission. However, our current understanding of this process is limited, particularly regarding the coordination between the early and late steps of endosomal fission. Here we have identified a novel interaction between the endosoma… Show more
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