Endoscopy in inflammatory bowel disease: from guidelines to real life

Negreanu, Lucian; Voiosu, Theodor; State, Monica; Voiosu, Andrei; Benguș, Andreea; Mateescu, Bogdan

doi:10.1177/1756284819865153

Cited by 22 publications

(18 citation statements)

References 52 publications

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“…Up to the moment of this review, limited information is available regarding the in vivo effects of cannabinoids on intestinal inflammatory conditions in humans. The outcome predictors in IBD trials usually include DAI, C-reactive protein (CRP), rapid fecal calprotectin (FC), the Mayo score and the Crohn's Disease Activity Index (CDAI), and the correct interpretation of the results relies on quality preparation for colonoscopy [81][82][83].…”

Section: Human Clinical Trialsmentioning

confidence: 99%

Cannabinoids and Inflammations of the Gut-Lung-Skin Barrier

Scheau

Căruntu

Bădărău

et al. 2021

JPM

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Recent studies have identified great similarities and interferences between the epithelial layers of the digestive tract, the airways and the cutaneous layer. The relationship between these structures seems to implicate signaling pathways, cellular components and metabolic features, and has led to the definition of a gut-lung-skin barrier. Inflammation seems to involve common features in these tissues; therefore, analyzing the similarities and differences in the modulation of its biomarkers can yield significant data promoting a better understanding of the particularities of specific signaling pathways and cellular effects. Cannabinoids are well known for a wide array of beneficial effects, including anti-inflammatory properties. This paper aims to explore the effects of natural and synthetic cannabinoids, including the components of the endocannabinoid system, in relation to the inflammation of the gut-lung-skin barrier epithelia. Recent advancements in the use of cannabinoids as anti-inflammatory substances in various disorders of the gut, lungs and skin are detailed. Some studies have reported mixed or controversial results, and these have also been addressed in our paper.

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Section: Human Clinical Trialsmentioning

confidence: 99%

Cannabinoids and Inflammations of the Gut-Lung-Skin Barrier

Scheau

Căruntu

Bădărău

et al. 2021

JPM

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“…However, in follow-up studies, a higher percentage/risk of relapse has been observed in patients who had reached a MES 1 index compared to the group with a MES 0 index (36.6% vs 9.4% with P < 0.001)[ 13 ]. On the other hand, an endoscopic response has been defined as a decrease in ≥ 1 degrees of the MES or a decrease in ≥ 2 points of the UCEIS[ 14 , 15 ].…”

Section: Endoscopy To Assess Disease Activitymentioning

confidence: 99%

Evolving role of endoscopy in inflammatory bowel disease: Going beyond diagnosis

Núñez¹,

Cleveland²,

Quera³

et al. 2021

WJG

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Inflammatory bowel disease, encompassing Crohn’s disease (CD) and ulcerative colitis, are chronic immune-mediated inflammatory bowel diseases (IBD) that primarily affect the gastrointestinal tract with periods of activity and remission. Large body of evidence exist to strengthen the prognostic role of endoscopic evaluation for both disease activity and severity and it remains the gold standard for the assessment of mucosal healing. Mucosal healing has been associated with improved clinical outcomes with prolonged remission, decreased hospitalization, IBD-related surgeries and colorectal cancer risk. Therefore, endoscopic objectives in IBD have been incorporated as part of standard care. With the known increased risk of colorectal cancer in IBD, although prevention strategies continue to develop, regular surveillance for early detection of neoplasia continue to be paramount in IBD patients’ care. It is thanks to evolving technology and visualization techniques that surveillance strategies are continuously advancing. Therapeutic endoscopic options in IBD have also been expanding, from surgery sparing therapies such as balloon dilation of fibrostenotic strictures in CD to endoscopic mucosal resection of neoplastic lesions. In this review article, we discuss the current evidence on the use of endoscopy as part of standard of care of IBD, its role in surveillance of neoplasia, and the role of interventional endoscopic therapies.

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“…Endoscopy plays an important role in the diagnosis and treatment of patients with inflammatory bowel disease (IBD) because it can assess the diagnosis and activity of the disease. 36 The current treatment strategy for ulcerative colitis (UC) patients aims to achieve mucosal healing, and the degree of mucosal healing is assessed and graded by a number of endoscopic indicators, including Mayo endoscopic score (MES) and ulcerative colitis endoscopic index of severity (UCEIS). However, many studies have shown that not only achieving mucosal healing, but also further achieving the goal of histological remission may lead to better treatment and prognosis.…”

Section: Colonmentioning

confidence: 99%

Application of linked color imaging in the diagnosis of early gastrointestinal neoplasms and precancerous lesions: a review

Wang

Luo

2021

Therap Adv Gastroenterol

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Introduction: Minimally invasive endoscopic resection is often effective in the management of early gastrointestinal tumors. However, advanced and more effective methods of endoscopic examination are required to improve the rate of diagnosing early gastrointestinal tumors. Discussion: The development of dye-based image-enhanced endoscopy (d-IEE) and equipment-based image-enhanced endoscopy (e-IEE) has helped improve the diagnostic rate of early gastrointestinal tumor using endoscopy. In some special cases, these methods are still not accurate in diagnosing lesions. On the basis of these e-IEEs, a new endoscopic technique, linked color imaging (LCI), that combines a specific short wavelength narrow band of light with white light, has been developed. Conclusion: In this article, we summarized the characteristics of LCI and the development of research regarding digestive tract examination. Plain language summary Application of linked color imaging in early gastrointestinal neoplasms At present, the complete diagnosis of early gastrointestinal tumors and precancerous lesions can be made by gastrointestinal endoscopy. With the improvement of therapeutic instruments and operators’ experience, endoscopic therapy can often achieve significant effect in the treatment of early gastrointestinal tumors. The development and spread of equipment-based image-enhanced endoscopy (e-IEE) mode has helped improve the diagnosis rate of early gastrointestinal tumors under endoscopy. However, in some special cases, these methods are still not accurate for the diagnosis of lesions. On the basis of these E-IEEs, a new endoscopic technique, linked color imaging (LCI), has been developed, which combines a specific short wavelength narrow band of light with white light. LCI can significantly improve the diagnostic rate of all types of gastrointestinal mucosal lesions. Tumor lesions and inflammatory lesions can be distinguished by observing the mucosal microvascular structure and color difference. LCI helps detect early gastrointestinal mucosal lesions by taking advantage of the differences in light absorption of different wavelengths and contrast of enhanced colors in the later stage.

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Endoscopy in inflammatory bowel disease: from guidelines to real life

Cited by 22 publications

References 52 publications

Cannabinoids and Inflammations of the Gut-Lung-Skin Barrier

Cannabinoids and Inflammations of the Gut-Lung-Skin Barrier

Evolving role of endoscopy in inflammatory bowel disease: Going beyond diagnosis

Application of linked color imaging in the diagnosis of early gastrointestinal neoplasms and precancerous lesions: a review

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