Endoscopic ultrasound of pancreatic tumors

Wangermez, Marc

doi:10.1016/j.diii.2016.10.002

Cited by 15 publications

(9 citation statements)

References 46 publications

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“…Clinicians routinely use endoscopic ultrasound (EUS) to guide fine-needle aspiration and biopsy (Chantarojanasiri et al 2016; Wangermez 2016). However, EUS-guided biopsy is difficult, often requiring multiple punctures to obtain a sufficient number of tissue samples.…”

Section: Introductionmentioning

confidence: 99%

Elastographic Assessment of Xenograft Pancreatic Tumors

Wang

Nieskoski

Marra

et al. 2017

Ultrasound in Medicine & Biology

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High tissue pressures prevent chemotherapeutics from reaching the parenchyma of pancreatic ductal adenocarcinoma, which makes it difficult to treat this aggressive disease. Researchers currently use invasive probes to monitor the effectiveness of pressure-reducing therapies, but this practice introduces additional complications. Here, we hypothesize that Young’s modulus is a good surrogate for tissue pressure because collagen density and hyaluoronic acid, the key features of the tumor microenvironment responsible for high tissue pressures, also affect modulus elastograms. To corroborate this hypothesis, we used model-based quasi-static elastography to assess how the Young’s modulus of naturally occurring AsPc-1 pancreatic tumors varies with collagen density and hyaluoronic acid concentration. We observed that Young’s moduli of orthotopically grown xenograft tumors were 6 kPa (p < 0.05) higher than that of their subcutaneously grown counterparts. We also observed a strong correlation between Young’s modulus and regions within the tumors with high collagen (R2 ≈ 0.8) and hyaluoronic acid (R2 ≈ 0.6) densities. These preliminary results indicate that hyaluronic acid and collagen density, features of the pancreatic ductal adenocarcinoma tumor microenvironment responsible for high tissue pressure, influence Young’s modulus.

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Section: Introductionmentioning

confidence: 99%

Elastographic Assessment of Xenograft Pancreatic Tumors

Wang

Nieskoski

Marra

et al. 2017

Ultrasound in Medicine & Biology

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“…Whereas the position of the pancreas is relatively deep and it is also di cult to take a EUS-FNA. An experienced radiologist can give a preliminary imaging diagnosis of PDAC, which tends to be hypovascular, suggesting hypoechoic on imaging [27]. However, it is di cult to distinguish whether the primary tumor has metastasized to other organs in imaging, because tumors can also metastasize through the hematogenous or the lymphatic pathway in addition to direct invasion.…”

Section: Discussionmentioning

confidence: 99%

Synchronous Pancreatic Acinar Cell Adenocarcinoma and Gastric Adenocarcinoma: a Case Report and Literature Review

Fang

Liang

Wang

et al. 2021

Preprint

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Background: Multiple primary malignant tumors are two or more malignancies in an individual without any relationship between the neoplasms. In recent years, increasing number of cases have been reported. However, Synchronous double primary gastric cancer and pancreatic acinar cell carcinoma are relatively rare to be reported. Further, most pancreatic tumors are consistent with pancreatic ductal adenocarcinomas, and other histologies are rare. We present the first case of synchronous pancreatic acinar cell adenocarcinoma and gastric adenocarcinoma.Case presentation: A 69-year-old man came to our department with a history of vomiting, epigastric pain, and weight loss. Imaging revealed space-occupying lesions in the stomach and the tail of the pancreas, respectively. The patient underwent laparoscopic radical gastrectomy and pancreatectomy simultaneously. The pathologies of surgical specimens were completely different: the resected gastric specimen was a moderate to poorly differentiated adenocarcinoma, whereas the pancreatic tumor was consistent with acinar cell carcinoma. The patient was treated with six cycles of oxaliplatin and S-1 chemotherapy. As of March 2021, the patient was healthy without any recurrence or metastasis. After reviewing lots of literatures on simultaneous pancreatic and gastric cancers at home and abroad, we discuss the clinical characteristics of these rare synchronous double cancers. Most of the cases had undergone surgery and adjuvant chemotherapy, and all of the cases were pathologically confirmed by postoperative specimen. Conclusions: Synchronous pancreatic acinar cell and gastric adenocarcinoma can occur and should be considered when tumors are found in these organs.

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“…Whereas the position of the pancreas is relatively deep and EUS-FNA is difficult. An experienced radiologist can give a preliminary imaging diagnosis of PDAC, which tends to be hypovascular, appearing hypoechoic on imaging[ 27 ]. However, it is difficult to distinguish whether or not the primary tumor has metastasized to other organs in imaging, because tumors can also metastasize through the hematogenous or the lymphatic pathway in addition to direct invasion.…”

Section: Discussionmentioning

confidence: 99%

Synchronous concomitant pancreatic acinar cell carcin and gastric adenocarcinoma: A case report and review of literature

Fang¹,

Liang²,

Wang³

et al. 2021

WJCC

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BACKGROUND Multiple primary malignant tumors are two or more malignancies in an individual without any relationship between the neoplasms. In recent years, an increasing number of cases have been reported. However, concomitant primary gastric and pancreatic cancer reported a relatively small incidence, involving no pancreatic acinar cell carcinoma reports. Here, we present the first case of concomitant pancreatic acinar cell carcinoma and gastric adenocarcinoma. CASE SUMMARY A 69-year-old male presented to our department with a history of vomiting, epigastric pain, and weight loss. Imaging revealed space-occupying lesions in the stomach and the tail of the pancreas, respectively. The patient underwent laparoscopic radical gastrectomy and pancreatectomy simultaneously. The pathologies of surgical specimens were completely different: The resected gastric specimen was moderate to poorly differentiated adenocarcinoma, whereas the pancreatic tumor was consistent with acinar cell carcinoma. The patient was treated with six cycles of oxaliplatin and S-1 chemotherapy. As of March 2021, the patient was healthy without any recurrence or metastasis. After thoroughly reviewing the literature on simultaneous pancreatic and gastric cancers at home and abroad, we discussed the clinical characteristics of these rare synchronous double cancers. Most of the cases had undergone surgery and adjuvant chemotherapy, and all of the cases were pathologically confirmed by the postoperative specimen. CONCLUSION Synchronous pancreatic acinar cells and gastric adenocarcinoma can occur and should be considered when tumors are found in these organs.

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Endoscopic ultrasound of pancreatic tumors

Cited by 15 publications

References 46 publications

Elastographic Assessment of Xenograft Pancreatic Tumors

Elastographic Assessment of Xenograft Pancreatic Tumors

Synchronous Pancreatic Acinar Cell Adenocarcinoma and Gastric Adenocarcinoma: a Case Report and Literature Review

Synchronous concomitant pancreatic acinar cell carcin and gastric adenocarcinoma: A case report and review of literature

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