Endoscopic ultrasound-guided fine-needle aspiration with or without flow cytometry for the diagnosis of primary pancreatic lymphoma – a case series

Khashab, Mouen A.; Mokadem, Mohamad; DeWitt, John M.; Emerson, Robert E.; Sherman, Stuart; Leblanc, Julia K.; McHenry, Lee; Al-Rashdan, Abdulla; Al-Haddad, Mohammed

doi:10.1055/s-0029-1243859

Cited by 47 publications

(42 citation statements)

References 9 publications

(11 reference statements)

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“…Table 1 summarizes 14 studies [24,27,28,29,30,31,32,33,34,35,36,37,38,39] focused on the efficacy of the diagnosis of deep-seated lymphomas using EUS/EBUS-FNA from the past 15 years. A direct comparison among these studies is not possible because each study has a unique design with different definitions of ‘gold standard', different statistical measures, and variable institutional workflows; nevertheless, they provide us a general overview of/progress in this field.…”

Section: Fna Diagnosis Of Deep-seated Lymphomas Via Eus/ebus Emphasimentioning

confidence: 99%

“…Overall, the specificity of detection was consistently higher than sensitivity. The addition of ancillary techniques, mainly FC, increased the sensitivity considerably (84.6-87%), as well as the specificity (93-100%), compared with using cytomorphological evaluation alone (sensitivity and specificity ranging from 30.8 to 87 and from 0 to 100%, respectively) [27,29,37]. …”

Section: Fna Diagnosis Of Deep-seated Lymphomas Via Eus/ebus Emphasimentioning

confidence: 99%

“…Because the management and outcome of PPLs are completely different from pancreatic epithelial neoplasms, accurate recognition of these rare tumors is essential. Several case series and considerable case reports have demonstrated that the diagnosis and further classification of PPLs using EUS-FNA is possible [29,62,63,64]. …”

Section: Fna Diagnosis Of Specific Organ-based Primary Deep-seated Lymentioning

confidence: 99%

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Endoscopic/Endobronchial Ultrasound-Guided Fine Needle Aspiration and Ancillary Techniques, Particularly Flow Cytometry, in Diagnosing Deep-Seated Lymphomas

Jin

Wakely²

2016

Acta Cytologica

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Evaluation of deep-seated lymphomas by fine-needle aspiration (FNA) can be challenging due to their reduced accessibility. Controversy remains as to whether FNA and ancillary techniques can be used to diagnose deep-seated lymphomas reliably and sufficiently for clinical management. Most published studies are favorable that endobronchial ultrasound (EBUS)/endoscopic ultrasound (EUS)-FNA plays an important role in the diagnosis of deep-seated lymphomas. The addition of ancillary techniques, particularly flow cytometry, increases diagnostic yield. While subclassification is possible in a reasonable proportion of cases, the reported rates of successful subclassification are lower than those for lymphoma detection/diagnosis. The diagnostic limitation exists for Hodgkin's lymphoma, grading of follicular lymphoma, and some T-cell lymphomas. The role of FNA in deep-seated lymphomas is much better established for recurrent than primary disease. It remains unclear whether the use of large-sized-needle FNA or a combination of core needle biopsy and FNA improves subclassification. It is important for cytopathologists to have considerable understanding of the WHO lymphoma classification and develop a collaborative working relationship with hematopathologists and oncologists. As EUS/EBUS-FNA techniques advance and sophisticated molecular techniques such as next- generation sequencing become possible, the role of FNA in the diagnosis of deep-seated lymphomas will possibly increase.

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Section: Fna Diagnosis Of Deep-seated Lymphomas Via Eus/ebus Emphasimentioning

confidence: 99%

Section: Fna Diagnosis Of Deep-seated Lymphomas Via Eus/ebus Emphasimentioning

confidence: 99%

Section: Fna Diagnosis Of Specific Organ-based Primary Deep-seated Lymentioning

confidence: 99%

See 1 more Smart Citation

Endoscopic/Endobronchial Ultrasound-Guided Fine Needle Aspiration and Ancillary Techniques, Particularly Flow Cytometry, in Diagnosing Deep-Seated Lymphomas

Jin

Wakely²

2016

Acta Cytologica

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“…When suspected, a cytological or histological sample is needed in order to prescribe a proper treatment [9] . Only one study evaluated the diagnostic utility of EUS-FNA in the diagnosis of PPL [2] . This case series included 14 patients with final diagnosis of PPL who underwent EUS-FNA.…”

Section: Pancreatic Lymphomamentioning

confidence: 99%

“…Whereas the diagnosis of gastrointestinal lymphomas is straight forward by taking multiple endoscopic biopsies [1] , the diagnosis of deep-seated nodal or primary organ lymphoma is often difficult or risky if percutaneous imaging techniques such as ultrasound (U.S.) or computed tomography (CT) are used [2,3] . In fact, most of them are diagnosed using invasive and expensive procedures such as thoracotomy, laparotomy, laparoscopy or mediastinoscopy.…”

Section: Introductionmentioning

confidence: 99%

Role of endoscopic ultrasonography with and without fine needle aspiration cytology in the diagnosis and staging of lymphoma

Alvarez-Buylla

García²,

Sánchez

et al. 2012

J Hemat Malig

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Diagnosis of lymphoma is frequently challenging. The complexity of the sub-classification of lymphomas along with the necessity of a high quality sample leads to costly and invasive procedures in order to achieve the correct diagnosis. Endoscopic ultrasound is a valuable tool for the diagnosis and staging of gastrointestinal neoplasms as well as those that involve structures in the vicinity of the digestive tract. Whereas most gastrointestinal lymphomas are diagnosed and sub-classified using endoscopic biopsies, those involving deep-seated organs or lymph nodes might be targeted by minimal invasive procedures as endoscopic ultrasound-guided fine needle aspiration cytology. Endoscopic ultrasound is also an accurate tool for the local staging of gastrointestinal lymphomas and prediction of the response to Helicobacter pylori eradication. This review summarizes the indications and evidence of endoscopic ultrasonography with or without fine needle aspiration cytology in the diagnosis and staging of lymphoma.

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Imaging modalities for characterising focal pancreatic lesions

Best

Rawji

Pereira

et al. 2017

Cochrane Database of Systematic Reviews

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Endoscopic ultrasound-guided fine-needle aspiration with or without flow cytometry for the diagnosis of primary pancreatic lymphoma – a case series

Cited by 47 publications

References 9 publications

Endoscopic/Endobronchial Ultrasound-Guided Fine Needle Aspiration and Ancillary Techniques, Particularly Flow Cytometry, in Diagnosing Deep-Seated Lymphomas

Endoscopic/Endobronchial Ultrasound-Guided Fine Needle Aspiration and Ancillary Techniques, Particularly Flow Cytometry, in Diagnosing Deep-Seated Lymphomas

Role of endoscopic ultrasonography with and without fine needle aspiration cytology in the diagnosis and staging of lymphoma

Imaging modalities for characterising focal pancreatic lesions

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