Endoscopic Ultrasound–Guided Biopsy of Pancreatic Metastases

Hajj, Ihab I. El; Leblanc, Julia K.; Sherman, Stuart; Al‐Haddad, Mohammad; Coté, Gregory A.; McHenry, Lee; DeWitt, John M.

doi:10.1097/mpa.0b013e31826b3acf

Cited by 70 publications

(85 citation statements)

References 23 publications

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“…The usefulness of EUS-guided tissue sampling in the diagnosis of pancreatic metastases has previously been reported [1, 5–7]. However, some of the metastatic tumors to the pancreas (e.g., esophageal and non-SCLC metastases) cannot be definitively confirmed by cytomorphology alone [5], and obtaining optimal histological samples is highly desirable to improve diagnostic accuracy and certainty.…”

Section: Discussionmentioning

confidence: 99%

“…Accurate identification of isolated pancreatic metastases is critical in determining the best surgical and/or medical management [1]. Although lung cancer can metastasize to the pancreas, the frequency ranges according to the histological subtype, and the incidence of pancreas involvement with squamous cell carcinoma is reported as 1.1% of all pancreatic metastases [2].…”

Section: Introductionmentioning

confidence: 99%

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An Unusual Case of Pancreatic Metastasis from Squamous Cell Carcinoma of the Lung Diagnosed by EUS-Guided Fine Needle Biopsy

Ishikawa

Hirooka

Teman

et al. 2017

Case Reports in Gastrointestinal Medicine

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We report a case of a 70-year-old man who presented with abdominal pain and weight loss, with initial imaging showing simultaneous mass lesions in the pancreas and lungs along with extensive lymphadenopathy in the thorax up to the left supraclavicular region. Core biopsies of the left supraclavicular lymph node showed squamous cell carcinoma, which required differentiation between secondary and primary pancreatic neoplasms. Endoscopic ultrasound-guided sampling using a novel fine needle biopsy system was key to making a definite histological diagnosis and determining the best treatment plan.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

An Unusual Case of Pancreatic Metastasis from Squamous Cell Carcinoma of the Lung Diagnosed by EUS-Guided Fine Needle Biopsy

Ishikawa

Hirooka

Teman

et al. 2017

Case Reports in Gastrointestinal Medicine

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“…In one series, El Hajj et al [6] studied 72 cases of cancer metastatic to the pancreas, 21 of which originated in the kidney, while Gilbert et al [7] compiled 25 cases of metastatic cancer in the pancreas, of which 12 were from a renal primary cancer. The differential diagnosis of pancreatic neoplasms with clear cell features includes primary pancreatic adenocarcinoma with clear cell (foamy cell) features, clear cell solid pseudopapillary tumor of the pancreas, perivascular epithelioid cell tumor (i.e.…”

Section: Discussionmentioning

confidence: 99%

Metastatic Renal Cell Carcinoma to the Pancreas: Diagnostic Significance of Fine-Needle Aspiration Cytology

Gilani¹,

Tashjian²,

Danforth³

et al. 2013

Acta Cytologica

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Background: Renal cell carcinoma rarely metastasizes to the pancreas. Diagnosing a neoplasm that is metastatic to the pancreas by fine-needle aspiration (FNA) cytology is often challenging. A detailed clinical history may prove to be beneficial. Case Reports: A total of 729 pancreatic FNAs were performed from January 2005 through August 2012 at our institution. Among these, we found 3 patients with a prior history of a malignant renal neoplasm who presented with a pancreatic mass: 2 in the tail and 1 in the head. Radiographically, they ranged in size from 2.5 to 7.0 cm. Microscopic evaluation of cytologic material obtained during endoscopic ultrasound-guided FNA (EUS-FNA) revealed cohesive clusters of atypical cells with clear cytoplasm and prominent nucleoli surrounded by a thin capillary network. The neoplastic cells were immunoreactive with CD10 (cases 2 and 3). A diagnosis of metastatic clear cell renal cell carcinoma was rendered for each case based on the morphologic features and immunohistochemical staining pattern of the neoplastic cells. Histologic comparison with the available slides of the corresponding primary renal neoplasm confirmed the diagnosis. Conclusion: We conclude that EUS-FNA of pancreatic masses is an important, effective, and accurate diagnostic modality for early diagnosis of both primary and metastatic neoplasms of the pancreas.

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“…18,19 Endoscopic ultrasonography with fine-needle aspiration is well established in clinical practice for the differential diagnosis of pancreatic lesions because of its safety 20 and accurateness. 21 However, EUS-FNA is not completely risk-free; it is expensive and requires a dedicated team of expert endosonographers and cytopathologists.…”

mentioning

confidence: 99%

Contrast Harmonic Endoscopic Ultrasonography in the Characterization of Pancreatic Metastases (With Video)

Fusaroli¹,

D'Ercole²,

Giorgio³

et al. 2014

Pancreas

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In our population, standard EUS features of PM were unremarkable. At CH-EUS, most of the PM appeared hypoenhancing suggesting a possible malignant origin. However, a subset of PM showed hyperenhancing pattern. In the appropriate context, particularly when cancer history is present, CH-EUS may add to the differential diagnosis and potentially spare endoscopic ultrasonography with fine-needle aspiration.

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Endoscopic Ultrasound–Guided Biopsy of Pancreatic Metastases

Abstract: Endoscopic ultrasound-FNA and EUS-TCB may assist with the cytological diagnosis of pancreatic metastases and may have a major clinical impact.

Cited by 70 publications

References 23 publications

An Unusual Case of Pancreatic Metastasis from Squamous Cell Carcinoma of the Lung Diagnosed by EUS-Guided Fine Needle Biopsy

An Unusual Case of Pancreatic Metastasis from Squamous Cell Carcinoma of the Lung Diagnosed by EUS-Guided Fine Needle Biopsy

Metastatic Renal Cell Carcinoma to the Pancreas: Diagnostic Significance of Fine-Needle Aspiration Cytology

Contrast Harmonic Endoscopic Ultrasonography in the Characterization of Pancreatic Metastases (With Video)

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