Endoscopic ultrasonography is useful for monitoring the tumor response of neoadjuvant chemoradiation therapy in esophageal squamous cell carcinoma

Owaki, Tetsuhiro; Matsumoto, Masataka; Okumura, Hiroshi; Uchicado, Y; Kita, Yoshiaki; Setoyama, Tetsuro; Sasaki, Ken; Sakurai, Toshihide; Omoto, Itaru; Shimada, Mario; Sakamoto, Fumiko; Yoshinaka, Heiji; Ishigami, Sumiya; Ueno, S.; Natsugoe, Shoji

doi:10.1016/j.amjsurg.2011.01.027

Cited by 13 publications

(9 citation statements)

References 36 publications

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“… 7 , 8 Several studies investigated the predictors of post-CRT prognosis, 9 – 11 whereas others analyzed pretreatment imaging findings and histopathological findings to reveal the predictors of CRT efficacy. 12 – 16 As in CRT, several studies reported the efficacy of neoadjuvant chemotherapy (CT), making it standard treatment for esophageal cancer. 17 – 21 However, except the studies using pretreatment imaging findings, no studies used pretreatment factors such as patient background and hematological findings to predict the outcomes of NAC(R)T. The discovery of pretreatment clinical or biopsy findings that can predict or enhance the efficacy of CRT or CT would enable us to establish more effective and individualized treatment strategies.…”

Section: Introductionmentioning

confidence: 99%

Factors Predicting Effectiveness of Neoadjuvant Therapy for Esophageal Squamous Cell Carcinoma

et al. 2016

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The aim of the study was to elucidate pretreatment factors that can predict the outcome of neoadjuvant chemoradiotherapy or chemotherapy (NAC(R)T) and help us choose treatment strategies appropriate for individual patients.Few studies have investigated whether clinical data obtainable before the treatment can predict the efficacy of NAC(R)T.Of 1540 patients treated for esophageal squamous cell carcinoma (ESCC) at our department between January 2000 and June 2014, those who underwent surgical resection of cStage II or more advanced ESCC after NAC(R)T (113 NACRT and 146 NACT patients) were enrolled in this study. Information all available before the treatment was analyzed to extract factors that can predict the effectiveness of NAC(R)T. NAC(R)T was considered effective when Grade 2 or greater treatment efficacy was achieved based on the histological grading system.NACRT was effective in 51 (45%) of 113 patients. The analysis of 35 pretreatment factors showed that female sex (hazard ratio [HR] = 3.650; 1.181–11.236), absence of dyslipidemia (HR = 3.284; 1.341–8.041), and histologically poorly differentiated tumor (HR = 2.431; 1.052–5.619) were factors predicting NACRT effectiveness. On the other hand, NACT was effective in 21 (14%) of 146 patients. The analysis of pretreatment factors showed that absence of dyslipidemia (HR = 10.204; 1.302–83.33) and therapy with docetaxel, cisplatin, and 5-fluorouracil (HR = 2.097; 1.027–4.280) were factors predicting NACT effectiveness.The findings of this study investigating factors that could predict the outcome of NAC(R)T suggest that the prevalence of dyslipidemia influences the outcome of NAC(R)T for ESCC.

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Section: Introductionmentioning

confidence: 99%

Factors Predicting Effectiveness of Neoadjuvant Therapy for Esophageal Squamous Cell Carcinoma

et al. 2016

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“…Ordinal CT scans may not distinguish post-inflammatory changes and fibrosis from cancer cells. Recently, there have been a few reports of endoscopic ultrasonography (EUS) performed in cases of neoadjuvant CRT or definitive CRT (21,22). Although it is insufficient to detect small cancer foci in the fibrotic tissue, EUS seems to be useful to determine whether CRT was effective or not.…”

Section: Discussionmentioning

confidence: 99%

Different strategy of salvage esophagectomy between residual and recurrent esophageal cancer after definitive chemoradiotherapy

et al. 2018

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Patients with residual cancer would have good prognosis by salvage esophagectomy in cases in which the cancer had not invaded to the adventitia at the time of chemoradiotherapy and surgery. Conversely, patients whose cancer was recurrent might benefit from salvage surgery if the cancer appears to be resectable. T and N status before chemoradiotherapy are not important factors in consideration of salvage esophagectomy in cases of recurrent cancer.

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“…EUS can identify residual submucosal tumors in the absence of superficial lesions. In addition, tumor size change or post‐CRT tumor size measured by EUS correlates with pathological response and predicts local recurrence after esophagectomy . CT scan is less accurate than EUS in assessing primary tumor response, but it offers an overview from neck to abdomen to assess size change in metastatic lesions .…”

Section: Introductionmentioning

confidence: 99%

“…In addition, tumor size change or post-CRT tumor size measured by EUS correlates with pathological response and predicts local recurrence after esophagectomy. [10][11][12][13] CT scan is less accurate than EUS in assessing primary tumor response, but it offers an overview from neck to abdomen to assess size change in metastatic lesions. 14,15 Previous studies had focused on analyzing the accuracy of these image modalities in predicting pathological response for patients treated by neoadjuvant CRT plus surgery.…”

Section: Introductionmentioning

confidence: 99%

Response evaluation with endoscopic ultrasound and computed tomography in esophageal squamous cell carcinoma treated by definitive chemoradiotherapy

Chang

Wang

Chung

et al. 2015

J of Gastro and Hepatol

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Endoscopic ultrasonography is useful for monitoring the tumor response of neoadjuvant chemoradiation therapy in esophageal squamous cell carcinoma

Cited by 13 publications

References 36 publications

Factors Predicting Effectiveness of Neoadjuvant Therapy for Esophageal Squamous Cell Carcinoma

Factors Predicting Effectiveness of Neoadjuvant Therapy for Esophageal Squamous Cell Carcinoma

Different strategy of salvage esophagectomy between residual and recurrent esophageal cancer after definitive chemoradiotherapy

Response evaluation with endoscopic ultrasound and computed tomography in esophageal squamous cell carcinoma treated by definitive chemoradiotherapy

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