Endoscopic ultrasonography-guided fine needle aspiration biopsy in follow-up patients with gastrointestinal stromal tumours

Kinoshita, Kazuo; Isozaki, Koji; Tsutsui, Shusaku; Kitamura, Shinji; Hiraoka, Shintaro; Watabe, Kenji; Nakahara, Masanori; Nagasawa, Yutaka; Kiyohara, Tatsuya; Miyazaki, Yoshiji; Hirota, Seiichi; Nishida, Toshirou; Shinomura, Yasuhisa; Matsuzawa, Yūji

doi:10.1097/00042737-200311000-00007

Cited by 39 publications

(31 citation statements)

References 21 publications

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“…Endoscopic ultrasonography (EUS) with fi ne-needle aspiration biopsy (FNAB) is useful as it allows for the detection of gene mutations. [39][40][41] Computed tomography has proven useful for staging and detecting small bowel or gastric lesions with exophytic growth. According to Nishida et al, screening with multidetector CT scans should be feasible for detecting occult symptomatic GIST.…”

Section: Discussionmentioning

confidence: 99%

Laparoscopic resection of sporadic synchronous gastric and jejunal gastrointestinal stromal tumors: Report of a case

Dell’Avanzato

Carboni²,

Palmieri

et al. 2009

Surg Today

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Multicentricity of gastrointestinal stromal tumors (GISTs) has been described only in patients with neurofibromatosis type 1 (NF1) or within the small intestine, and different pathogenetic mechanisms are involved. We report a case of synchronous sporadic gastric and jejunal GISTs, which were resected laparoscopically in a 67-year-old man. Immunohistochemical analysis revealed that both lesions were KIT (CD117)-positive, but that the gastric lesion was CD34-positive, whereas the jejunal one was Vimentin-, S-100-, and SMA-positive. Molecular analysis of mutations in KIT exons 9, 11, 13, and 17, and in PDGFRA exons 12 and 18 revealed the presence of a gastric sporadic GIST with a KIT mutation of the exon 11 and a jejunal sporadic GIST without KIT or PDGFRA mutations. To our knowledge, this is the first report of laparoscopically resected synchronous sporadic gastric and jejunal GISTs.

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Section: Discussionmentioning

confidence: 99%

Laparoscopic resection of sporadic synchronous gastric and jejunal gastrointestinal stromal tumors: Report of a case

Dell’Avanzato

Carboni²,

Palmieri

et al. 2009

Surg Today

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“…But one case in our study with a diameter of 3.2 cm was eventually diagnosed as leiomyoma by pathology. Endoscopic ultrasonography guided fine needle aspiration (FNA) can further help to diagnose the submucosal masses [15] . EUS is useful in determining the therapy for SMT of the large intestine [16] .…”

Section: Discussionmentioning

confidence: 99%

Role of endoscopic miniprobe ultrasonography in diagnosis of submucosal tumor of large intestine

Zhou

Yao²,

Zhong³

et al. 2004

WJG

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AIM:To evaluate the role of miniprobe ultrasonography under colonoscope in the diagnosis of submucosal tumor of the large intestine, and to determine its imaging characteristics. METHODS:Thirty-five patients with submucosal tumors of the large intestine underwent miniprobe ultrasonography under colonoscope. The diagnostic results of miniprobe ultrasonography were compared with pathological findings of specimens by biopsy and surgical resection. RESULTS:Lipomas were visualized as hyperechoic homogeneous masses located in the submucosa with a distinct border. Leiomyomas were visualized as hypoechoic homogeneous mass originated from the muscularis propria. Leiomyosarcomas were shown with inhomogeneous echo and irregular border. Carcinoids were presented as submucosal hypoechoic masses with homogenous echo and distinct border. Lymphangiomas were shown as submocosal hypoechoic masses with cystic septal structures. Malignant lymphomas displayed as hypoechoic masses from mucosa to muscularis propria, while pneumatosis cystoids intestinalis originated from submucosa with a special sonic shadow. One large leiomyoma was misdiagnosed as leiomyosarcoma. CONCLUSION:Endoscopic miniprobe ultrasonography can provide precise information about the size, layer of origin, border of submucosal tumor of the large intestine and has a high accuracy in the diagnosis of submucosal tumor of the large intestine. Pre-operative miniprobe ultrasonography under colonoscope may play an important role in the choice of therapy for submucosal tumor of the large intestine.Zhou PH, Yao LQ, Zhong YS, He GJ, Xu MD, Qin XY. Role of endoscopic miniprobe ultrasonography in diagnosis of submucosal tumor of large intestine.

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“…Estimation of vascularity by contrastenhanced US seems more useful than the other diagnostic methods, particularly for small GISTs, those less than 50 mm in diameter. Because the specimens by endoscopic US guided biopsy 34,35 were very small, it is difficult to count mitosis of the tumors with insufficient materials. The "estimation of vascularity" was supposed to enable more accurate diagnosis before resection.…”

Section: Discussionmentioning

confidence: 99%

Estimation of the malignant potential of gastrointestinal stromal tumors: the value of contrast-enhanced coded phase-inversion harmonics US

et al. 2005

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Endoscopic ultrasonography-guided fine needle aspiration biopsy in follow-up patients with gastrointestinal stromal tumours

Abstract: EUS-FNAB against SMTs was useful for the differential diagnosis of SMT and the analysis of c-kit mutation. The c-kit mutation might not be one of the predictable markers for rapid tumour growth.

Cited by 39 publications

References 21 publications

Laparoscopic resection of sporadic synchronous gastric and jejunal gastrointestinal stromal tumors: Report of a case

Laparoscopic resection of sporadic synchronous gastric and jejunal gastrointestinal stromal tumors: Report of a case

Role of endoscopic miniprobe ultrasonography in diagnosis of submucosal tumor of large intestine

Estimation of the malignant potential of gastrointestinal stromal tumors: the value of contrast-enhanced coded phase-inversion harmonics US

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