Endoscopic Ultrasonography, Fine-Needle Aspiration Biopsy Guided by Endoscopic Ultrasonography, and Computed Tomography in the Preoperative Staging of Non-Small-Cell Lung Cancer: A Comparison Study

Gress, Frank G.

doi:10.7326/0003-4819-127-8_part_1-199710150-00004

Cited by 286 publications

(134 citation statements)

References 0 publications

Supporting

Mentioning

117

Contrasting

Unclassified

Order By: Relevance

“…Using real-time ultrasound-guided FNA, the current authors have achieved a sensitivity rate of 85% and an overall accuracy of 89%. Although these results should be regarded as preliminary due to the small numbers of patients involved, the sensitivity and accuracy are similar to those obtained by others using EBUS-TBNA [12,13] and also in EUS-FNA series [14][15][16]. Furthermore, the EBUS-TBNA results are for the first 20 cases performed in the current authors' institution using this method, indicating that a high sensitivity and accuracy rate can be obtained with relatively limited experience of the technique.…”

Section: Discussionsupporting

confidence: 65%

Endobronchial and endoscopic ultrasound-guided real-time fine-needle aspiration for mediastinal staging

Rintoul

Skwarski²,

Murchison³

et al. 2005

European Respiratory Journal

265

154

View full text Add to dashboard Cite

Accurate staging of the mediastinum in lung cancer is essential for optimising treatment strategies. Conventional transbronchial needle aspiration (TBNA) is a blind procedure, reliant upon prior computed tomography (CT) or ultrasound imaging, but has low sensitivity. The current study reports the initial experience of using a prototype endobronchial ultrasound (EBUS) probe that allows TBNA under real-time imaging.In 20 patients selected by CT scanning, a linear-array ultrasound bronchoscope was used to visualise paratracheal and hilar lymph nodes, and TBNA was performed under direct ultrasonic control. In seven cases, sequential endoscopic ultrasound (EUS) was used to assess posteroinferior mediastinal lymph nodes. All procedures were performed under conscious sedation.EBUS-TBNA was undertaken in 18 out of 20 cases and EUS-guided fine-needle aspiration in six out of seven cases. Cytology showed node (N)2/N3 disease in 11 out of 18 EBUS-TBNA cases and provided a primary diagnosis for eight patients. EBUS-TBNA cytology was negative in six cases, which was confirmed by mediastinoscopy or clinical follow-up in four. EUS provided additional information in all cases. There were no procedural complications. Sensitivity, specificity and accuracy for EBUS-TBNA were 85%, 100% and 89%, respectively.In conclusion, endobronchial ultrasound with real-time transbronchial needle aspiration offers improved sensitivity and accuracy for staging of the middle mediastinum, and, combined with endoscopic ultrasound, should allow investigation of the majority of the mediastinum.

show abstract

Section: Discussionsupporting

confidence: 65%

Endobronchial and endoscopic ultrasound-guided real-time fine-needle aspiration for mediastinal staging

Rintoul

Skwarski²,

Murchison³

et al. 2005

European Respiratory Journal

265

154

View full text Add to dashboard Cite

show abstract

“…In contrast, both TBNA and EUS-FNA are minimally invasive and can be performed in the outpatient setting under local anesthesia and sedation. EUS-FNA permits real-time visualization of needle sampling and has been shown to be highly accurate in the mediastinal staging of lung cancer, as well as in the diagnosis of mediastinal lymphadenopathy of unknown etiology [6,[12][13][14][15][16][17][18] . The development of EBUS-TBNA for mediastinal lymph nodes has lagged behind EUS-FNA by more than a decade [19,20] .…”

Section: Discussionmentioning

confidence: 99%

First endoscopic procedure for diagnosis and staging ofmediastinal lymphadenopathy

Khoo¹,

Ho²,

Khor³

et al. 2009

WJG

View full text Add to dashboard Cite

AIM:To compare a first diagnostic procedure of trans bronchial needle aspiration (TBNA) with selection of endoscopic ultrasoundguided fineneedle aspiration (EUSFNA) or TBNA for mediastinal lymphadenopathy. METHODS:Sixty-eight consecutive patients with mediastinal lymphadenopathy on computed tomography (CT), who required cytopathological diagnosis, were recruited. The first 34 underwent a sequential approach in which TBNA was performed first, followed by EUS FNA if TBNA was unrevealing. The next 34 underwent a selective approach where either TBNA or EUS-FNA was selected as the first procedure based on the CT findings. RESULTS:The diagnostic yield of TBNA as the first diagnostic procedure in the sequential approach was 62%. In the selective approach, the diagnostic yield of the first procedure was 71%. There was no significant difference in the overall diagnostic yield, but there were significantly fewer combined procedures with the selective approach. CONCLUSION:Selecting either EUS-FNA or TBNA as the first diagnostic procedure achieved a comparable diagnostic yield with significantly fewer procedures than performing TBNA first in all patients.

show abstract

“…[26][27][28]47,48 In a prospective study of 84 patients with mediastinal masses suspected of being malignant, EUS prevented thoracotomy or thoracoscopy in 48% and mediastinoscopy in 68% of patients by demonstrating lymph node metastases. 26 In another study of 59 patients, all scheduled for mediastinoscopy, EUS-FNA proved mediastinal metastases in 39% of patients, and mediastinoscopy was eventually performed in only 22%.…”

Section: Impact Of Eus On Patient Managementmentioning

confidence: 99%

“…[23][24][25][26][27][28][29][30][31][32][33] In a meta-analysis of 18 studies of EUS-FNA for the mediastinal staging of lung cancer, overall sensitivity was 83% and specificity was 97%. 23 The overall accuracy of EUS-FNA (i.e., weighted mean of sensitivity and specificity) is of 83% to 97% and a sensitivity of 84% to 92%.…”

Section: Accuracy Of Eus-fnamentioning

confidence: 99%

Role of endoscopic ultrasound in non-small cell lung cancer

Bhatia

Puri

2016

Int J Gastrointest Interv

View full text Add to dashboard Cite

Lung carcinoma is a common cause of mortality and morbidity worldwide. Non-small cell lung cancer (NSCLC) accounts for majority of cases worldwide. Accurate staging of NSCLC is of paramount importance due to marked difference in survival and management strategies between stage II and III of the disease. The staging methods have evolved from invasive thoracotomies and mediastinoscopies to relatively non-invasive complete mediastinal staging by combination of endoscopic ultrasound (EUS) and endoscopic bronchial ultrasound (EBUS). EUS also provides information about mediastinal invasion and liver/adrenal metastasis. Future role of EUS include providing tissue for molecular targeted therapy.

show abstract

Endoscopic Ultrasonography, Fine-Needle Aspiration Biopsy Guided by Endoscopic Ultrasonography, and Computed Tomography in the Preoperative Staging of Non-Small-Cell Lung Cancer: A Comparison Study

Cited by 286 publications

References 0 publications

Endobronchial and endoscopic ultrasound-guided real-time fine-needle aspiration for mediastinal staging

Endobronchial and endoscopic ultrasound-guided real-time fine-needle aspiration for mediastinal staging

First endoscopic procedure for diagnosis and staging ofmediastinal lymphadenopathy

Role of endoscopic ultrasound in non-small cell lung cancer

Contact Info

Product

Resources

About